The effects of gene associated with sucrose phosphotransferase system on biofilm formation of Streptococcus mutans

Research Project

Project/Area Number	22890123
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Conservative dentistry
Research Institution	The University of Tokushima
Principal Investigator	KIMURA Tomoko 徳島大学, 病院, 助教 (20581367)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥2,795,000 (Direct Cost: ¥2,150,000、Indirect Cost: ¥645,000) Fiscal Year 2011: ¥1,235,000 (Direct Cost: ¥950,000、Indirect Cost: ¥285,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	歯学 / う蝕 / 細菌 / 遺伝子 / バイオフィルム
Research Abstract	The aim of this study was to investigate the relationship between scrA gene deeply related to the acidogenic activity in cariogenic bacterium, Streptococcus mutans, and biofilm formation. Scanning electron microscopic observation and real-time PCR analysis demonstrated that scrA gene affects the expression of various genes involved in the synthesis of glucan, a component of biofilm.

Report

(3 results)