| Project/Area Number |
22890124
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
|
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,977,000 (Direct Cost: ¥2,290,000、Indirect Cost: ¥687,000)
Fiscal Year 2011: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 前駆脂肪細胞 / DDT / CD74 / ERK / IL-6 / 脂肪細胞分化 / 転写調節 / D-Dopachrome tautomerase / 脂肪細胞 / アディポカイン / 肥満 |
|---|
| Research Abstract |
D-dopachrome tautomerase(DDT), a novel adipokine, induces mRNA expression of IL-6 in preadipocytes. The DDT-induced IL-6 expression was found to be mediated by CD74. DDT impaired adipogenesis by inhibiting mRNA induction of adipogenic regulators during adipogenesis. Furthermore, the DDT promoter region involved the transcription in adipocytes was identified.
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