| Project/Area Number |
22890126
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,977,000 (Direct Cost: ¥2,290,000、Indirect Cost: ¥687,000)
Fiscal Year 2011: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | レジスチン / 歯周炎 / 糖尿病 / 好中球 / 単球 |
|---|
| Research Abstract |
The aim of this study is investigate a role of resistin, an adipocytokine related to diabetes mellitus(DM), in periodontitis. When resistin level in gingival crevicular fluid(GCF) was examined, reisitin level in GCF samples from periodontitis and DM-related periodontitis was higher than that of healthy sites. Lipopolysaccharide of P. gingivalis(P-LPS) increased a release of resistin from human neutrophils and its induction was inhibited with actin polymerization inhibitors. In contrast, advanced glycation end-products(AGEs) and P-LPS did not clearly affect on resistin expression in human macrophages derived from the U937 cell line. The present result shows resistin may modulate an inflammation in periodontal diseases.
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