Is resistin a novel modulator of periodontits?

• Project/Area Number: 22890126
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: MURATA Hiromi 徳島大学, 病院, 医員 (00583874)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,977,000 (Direct Cost: ¥2,290,000、Indirect Cost: ¥687,000); Fiscal Year 2011: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: レジスチン / 歯周炎 / 糖尿病 / 好中球 / 単球

Research Abstract

The aim of this study is investigate a role of resistin, an adipocytokine related to diabetes mellitus(DM), in periodontitis. When resistin level in gingival crevicular fluid(GCF) was examined, reisitin level in GCF samples from periodontitis and DM-related periodontitis was higher than that of healthy sites. Lipopolysaccharide of P. gingivalis(P-LPS) increased a release of resistin from human neutrophils and its induction was inhibited with actin polymerization inhibitors. In contrast, advanced glycation end-products(AGEs) and P-LPS did not clearly affect on resistin expression in human macrophages derived from the U937 cell line. The present result shows resistin may modulate an inflammation in periodontal diseases.

Research Products

• [Journal Article] Resistin in gingival crevicular fluid and induction of resistin release by Porphyromonas gingivalis lipopoly saccharide in human neutrophil (2012)
  • Author(s): Hiroshima Y, Bando M, Inagaki Y et al.
  • Journal Title: J Periodont Res Volume: (in press) Issue: 5 Pages: 554-652
  • DOI: 10.1111/j.1600-0765.2011.01466.x
  • Peer Reviewed
• [Presentation] バイオマーカーを用いた糖尿病関連歯周炎の診断研究 (2012)
  • Author(s): 木戸淳一, 稲垣裕司, 板東美香, 廣島佑香, 村田裕美, 美原智恵, 堀部ますみ, 米田哲, 二宮雅美, 大石慶二, 坂本英次郎, 中島由紀子, 生田貴久, 浅原洋士, 永田俊彦
  • Organizer: 第28回歯科医学を中心とした総合的な研究を推進する集い
  • Place of Presentation: 東京(歯科医師会館)
  • Year and Date: 2012-01-07
• [Presentation] 最終糖化産物はマクロファージ様細胞の炎症関連因子の発現を調節する (2011)
  • Author(s): 村田裕美
  • Organizer: 第135回日本歯科保存学会秋季学術大会
  • Place of Presentation: 大阪国際交流センター(大阪府)
  • Year and Date: 2011-10-21
• [Presentation] 歯肉溝滲出液中のYKL-40の分析 (2011)
  • Author(s): 坂東由記子, 木戸淳一, 廣島佑香, 板東美香, 稲垣裕司, 村田裕美, 四釜洋介, 船木真理, 永田俊彦
  • Organizer: 第54回日本歯周病学会秋季学術大会
  • Place of Presentation: 下関(海峡メッセ下関)
  • Year and Date: 2011-09-24
• [Presentation] 最終糖化産物はマクロファージ様細胞の炎症関連因子の発現を調節する (2011)
  • Author(s): 村田裕美, 木戸淳一, 板東美香, 廣島佑香, 稲垣裕司, 永田俊彦
  • Organizer: 第135回日本歯科保存学会秋季学術大会
  • Place of Presentation: 大阪(大阪国際交流センター)
• [Presentation] 歯肉溝滲出液中のグリコアルブミン測定法の確立 (2011)
  • Author(s): 板東美香, 稲垣裕司, 木戸淳一, 廣島佑香, 片岡正俊, 村田裕美, 坂東由記子, 二宮雅美, 坂本英次郎, 中島由紀子, 永田俊彦
  • Organizer: 第54回日本歯周病学会春季学術大会
  • Place of Presentation: 福岡(福岡国際会議場)