| Project/Area Number |
22890128
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Parasitology (including Sanitary zoology)
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
SHINZAWA Naoaki 愛媛大学, 大学院・医学系研究科, 助教 (10583015)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
|
|---|
| Keywords | ハマダラカ / マラリア / 自然免疫 / 分子生物学 / 媒介昆虫 / 分子遺伝学 |
|---|
| Research Abstract |
Blood-feeding assay of rodent malaria parasites with Anopheles stephensi revealed that a wild-type variant, named as PbR, represented refractoriness for P. berghei, but not for P. yoelii. In parasites stage-specific analysis, we found incomplete differentiation to ookinetes in the PbR midgut in P. berghei infection. Our results suggest that midgut-parasites interaction control parasite-differentiation which is the key factor of adaptation mechanisms evolving specie-specifically.
|
