| Budget Amount *help |
¥2,912,000 (Direct Cost: ¥2,240,000、Indirect Cost: ¥672,000)
Fiscal Year 2011: ¥1,456,000 (Direct Cost: ¥1,120,000、Indirect Cost: ¥336,000)
Fiscal Year 2010: ¥1,456,000 (Direct Cost: ¥1,120,000、Indirect Cost: ¥336,000)
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| Research Abstract |
In this study, we examined the degeneration of articular cartilage induced by joint immobilization and the effects of continuous passive motion(CPM) on cartilage degeneration. Immobilization resulted in thinning of the articular cartilage after two-week immobilization and loss of proteoglycan content after four-week immobilization. On the other hands, CPM applied for immobilization period rectified all degenerative changes induced by joints immobilization in the articular cartilage. Additionally, CPM inhibited the increase of Matrix metalloproteinases and the decrease of tissue inhibitor of metalloproteinase.
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