An experimental studies of degenerative change of the articular cartilage induced by the joint immobilization and the effect of the joint motion
Project/Area Number |
22890139
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Orthopaedic surgery
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Research Institution | Nagasaki University |
Principal Investigator |
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥2,912,000 (Direct Cost: ¥2,240,000、Indirect Cost: ¥672,000)
Fiscal Year 2011: ¥1,456,000 (Direct Cost: ¥1,120,000、Indirect Cost: ¥336,000)
Fiscal Year 2010: ¥1,456,000 (Direct Cost: ¥1,120,000、Indirect Cost: ¥336,000)
|
Keywords | 不動 / 関節軟骨 / 軟骨基質 / 退行性変化 / 持続的他動運動 / 関節不動 / MMP / TIMP |
Research Abstract |
In this study, we examined the degeneration of articular cartilage induced by joint immobilization and the effects of continuous passive motion(CPM) on cartilage degeneration. Immobilization resulted in thinning of the articular cartilage after two-week immobilization and loss of proteoglycan content after four-week immobilization. On the other hands, CPM applied for immobilization period rectified all degenerative changes induced by joints immobilization in the articular cartilage. Additionally, CPM inhibited the increase of Matrix metalloproteinases and the decrease of tissue inhibitor of metalloproteinase.
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Report
(3 results)
Research Products
(26 results)
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[Presentation] 大腿骨近位部骨折術後の痛みの発生状況に関する調査2011
Author(s)
片岡英樹, 西川正吾, 渋谷美帆子, 岩佐恭平, 山口紗智, 村上正寛, 中川勇樹, 吉田奈央, 鵜殿紀子, 濱崎忍, 三村国秀, 山下潤一郎, 坂本淳哉, 中野治郎, 沖田実
Organizer
第46回日本理学療法学術大会
Place of Presentation
宮崎
Related Report
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