The study of interaction between cardiac preconditioning and perioperative drugs

• Project/Area Number: 22890141
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Nagasaki University
• Principal Investigator: MATSUMOTO Syuhei 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20580327)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000); Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000); Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
• Keywords: 心臓 / 虚血再灌流 / 麻酔薬 / リモートプレコンディショニング / プロポフォール / セボフルラン / 虚血再灘流 / 活性酸素種

Research Abstract

We investigated about the effect of remote preconditioning against myocardial ischemia reperfusion injury.
Five times of remote preconditioning stimulus induced by both lower limb ischemia exerted myocardial protective effect.
Intravenous anesthetic propofol infusion inhibited its protective effects. whereas remote preconditioning and inhaled anesthetic sevoflurane exerts additive protective effects.

Research Products

• [Journal Article] Hyperglycemia raises the threshold of levosimendan-but not milrinone-induced postconditioning in rat hearts (2012)
  • Author(s): Matsumoto S, Cho S, Tosaka S, Higashijima U, Maekawa T, Hara T, Sumikawa K.
  • Journal Title: Cardiovasc Diabetol Volume: 11 : 4
• [Journal Article] High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats : role of mitochondrial KATP channels (2012)
  • Author(s): Ichinomiya T, Cho S, Higashijima U, Matsumoto S, Maekawa T, Sumikawa K.
  • Journal Title: Cardiovasc Diabetol Volume: 11(1): 28
• [Journal Article] Hyperglycemia raises the threshold of levosimendan-but not milrinone-induced postconditioning in rat hearts (2012)
  • Author(s): 松本周平, 趙成三, 戸坂真也, 東島潮, 前川拓治, 原哲也, 澄川耕二
  • Journal Title: Cardiovascular Diabetology Volume: 11:4 Issue: 1 Pages: 4-4
  • DOI: 10.1186/1475-2840-11-4
  • Peer Reviewed
• [Journal Article] Roles of cyclooxygenase 2 in sevoflurane-and olprinone-induced early phase of preconditioning and postconditioning against myocardial infarction in rat hearts (2011)
  • Author(s): Tosaka S, Tosaka R, Matsumoto S, Maekawa T, Cho S, Sumikawa K.
  • Journal Title: J Cardiovasc Pharmacol Ther Volume: 16 Pages: 72-8
• [Journal Article] Roles of cyclooxygenase 2 in sevoflurane- and olprinone-induced early phase of preconditioning and postconditioning against myocardial infarction in rat hearts. (2011)
  • Author(s): 戸坂真也、戸坂玲子、松本周平、前川拓治、趙成三、澄川耕二
  • Journal Title: J Cardiovasc Pharmacol Ther. Volume: 16 Pages: 72-78
  • Peer Reviewed
• [Presentation] Levosimendan-but not Milrinone-induced Postconditioning is Dependent on Cyclooxygenase-2 in Rat Hearts (2012)
  • Author(s): Ushio Higashijima, Sungsam Cho, Hiroyuki Ureshino, Shuhei Matsumoto, Koji Sumikawa
  • Organizer: Annual meeting of American society of anesthesiologists
  • Place of Presentation: Chicago
• [Presentation] Levosimendan-but not Milrinone-induced Postconditioning is Dependent on Cyclooxygenase-2 in Rat Hearts (2011)
  • Author(s): 東島潮, 趙成三, 嬉野浩行, 松本周平, 澄川耕二
  • Organizer: アメリカ麻酔学会(ASA)
  • Place of Presentation: Chicago
  • Year and Date: 2011-10-19
• [Presentation] Differential Effects of Hyperglycemia on Milrinone- and Levosimendan-Induced Postconditioning (2010)
  • Author(s): 松本周平、嬉野浩行、東島潮、趙成三、澄川耕二
  • Organizer: アメリカ麻酔学会(ASA)
  • Place of Presentation: サンディエゴ
  • Year and Date: 2010-10-18
• [Presentation] Fasudil Exerts Postconditioning Against Myocardial Infarction through eNOS Activation (2010)
  • Author(s): 前川拓治、一ノ宮大雅、松本周平、趙成三、澄川耕二
  • Organizer: アメリカ麻酔学会(ASA)
  • Place of Presentation: サンディエゴ
  • Year and Date: 2010-10-18
• [Presentation] The Role of Protein Kinase C in Milrinone- and Levosimendan-Induced Postconditioning in Rat Hearts (2010)
  • Author(s): 東島潮、趙成三、松本周平、嬉野浩行、澄川耕二
  • Organizer: アメリカ麻酔学会(ASA)
  • Place of Presentation: サンディエゴ
  • Year and Date: 2010-10-18