The study of interaction between cardiac preconditioning and perioperative drugs
| Project/Area Number |
22890141
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagasaki University |
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Principal Investigator |
MATSUMOTO Syuhei 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20580327)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
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| Keywords | 心臓 / 虚血再灌流 / 麻酔薬 / リモートプレコンディショニング / プロポフォール / セボフルラン / 虚血再灘流 / 活性酸素種 |
|---|
| Research Abstract |
We investigated about the effect of remote preconditioning against myocardial ischemia reperfusion injury.
Five times of remote preconditioning stimulus induced by both lower limb ischemia exerted myocardial protective effect.
Intravenous anesthetic propofol infusion inhibited its protective effects. whereas remote preconditioning and inhaled anesthetic sevoflurane exerts additive protective effects.
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Report
(3 results)
Research Products
(10 results)
