| Budget Amount *help |
¥2,977,000 (Direct Cost: ¥2,290,000、Indirect Cost: ¥687,000)
Fiscal Year 2011: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
We investigated expression of CYLD and its role in oral squamous cell carcinoma(OSCC). CYLD expression was significantly reduced at invasive lesions in OSCC tissues and correlated with poor prognosis. CYLD knockdown led to EMT-like changes in OSCC cell lines in the TGFBR1-dependent manner. Interestingly, CYLD repression led to resistance to cisplatin, but increased susceptibility to EGFR inhibitors-inducible apoptosis. Downregulation of CYLD may promote OSCC progression but EGFR may be an Achilles' heel of such aggressive cell populations. Further studies probably provide novel therapeutic strategies in OSCC.
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