Research Project
Grant-in-Aid for Research Activity Start-up
During cardiac hypertrophy, gene transcriptions are activated through GATA4, a transcription factor expressed in cardiomyocytes. The purpose of this study is to investigate the molecular mechanism of GATA4 transcriptional pathway and the involvement in angiogenesis. A novel GATA4 binding protein PRMT5 suppressed the gene transcription induced by GATA4 and p300, a coactivator of GATA4.Although the involvement in angiogenesis is not clear, the finding suggests that PRMT5 is a novel modulator of p300/GATA4 transcriptional pathway.
All 2012 2011 2010
All Journal Article (9 results) (of which Peer Reviewed: 4 results) Presentation (13 results)
Biol Pharm Bull
Volume: 35(2) Pages: 139-144
130001872286
Biol Pharm Bull.2012;35(2):139-44
Volume: 35 Pages: 139-44
Circ J
Volume: 75(9) Pages: 2151-2159
10029339526
Breast Cancer Res
Volume: 13(3) Pages: 66-66
Volume: 34(5) Pages: 660-665
130000657776
Invest New Drugs
Volume: 29(6) Pages: 1198-205
Volume: 29 Issue: 6 Pages: 1198-205
10.1007/s10637-010-9464-9
Volume: 75 Pages: 2151-9
Volume: 13 Issue: 3
10.1186/bcr2903