Mechanistic study of p300/GATA4 transcriptional pathway and novel GATA4 binding proteins in angiogenesis

• Project/Area Number: 22890153
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: University of Shizuoka
• Principal Investigator: KATANASAKA Yasufumi 静岡県立大学, 薬学部, 助教 (00583973)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2011: ¥1,157,000 (Direct Cost: ¥890,000、Indirect Cost: ¥267,000); Fiscal Year 2010: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
• Keywords: 心肥大 / 血管新生 / p300 / GATA4 / 新規GATA4結合分子 / GATA4結合分子 / p300/GATA4経路

Research Abstract

During cardiac hypertrophy, gene transcriptions are activated through GATA4, a transcription factor expressed in cardiomyocytes. The purpose of this study is to investigate the molecular mechanism of GATA4 transcriptional pathway and the involvement in angiogenesis. A novel GATA4 binding protein PRMT5 suppressed the gene transcription induced by GATA4 and p300, a coactivator of GATA4.Although the involvement in angiogenesis is not clear, the finding suggests that PRMT5 is a novel modulator of p300/GATA4 transcriptional pathway.

Research Products

• [Journal Article] A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats (2012)
  • Author(s): Sunagawa Y, Wada H, Suzuki H, Sasaki H, Imaizumi A, Fukuda H, Hashimoto T, Katanasaka Y, Shimatsu A, Kimura T, Kakeya H, Fujita M, Hasegawa K, Morimoto T
  • Journal Title: Biol Pharm Bull Volume: 35(2) Pages: 139-144
  • NAID: 130001872286
• [Journal Article] A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats (2012)
  • Author(s): Sunagawa Y, Wada H, Suzuki H, Sasaki H, Imaizumi A, Fukuda H, Hashimoto T, Katanasaka Y, Shimatsu A, Kimura T, Kakeya H, Fujita M, Hasegawa K, Morimoto T
  • Journal Title: Biol Pharm Bull.2012;35(2):139-44 Volume: 35 Pages: 139-44
  • NAID: 130001872286
  • Peer Reviewed
• [Journal Article] A natural p300-specific histone acetyltransferase inhibitor, curcumin, in addition to angiotensin-converting enzyme inhibitor, exerts beneficial effects on left ventricular systolic function after myocardial infarction in rats (2011)
  • Author(s): Sunagawa Y, Morimoto T, Wada H, Takaya T, Katanasaka Y, Kawamura T, Yanagi S, Marui A, Sakata R, Shimatsu A, Kimura T, Kakeya H, Fujita M, Hasegawa K
  • Journal Title: Circ J Volume: 75(9) Pages: 2151-2159
  • NAID: 10029339526
• [Journal Article] Sunitinib inhibits lymphatic endothelial cell functions and lymph node metastasis in a breast cancer model through inhibition of vascular endothelial growth factor receptor 3 (2011)
  • Author(s): Kodera Y, Katanasaka Y, Kitamura Y, Tsuda H, Nishio K, Tamura T, Koizumi F
  • Journal Title: Breast Cancer Res Volume: 13(3) Pages: 66-66
• [Journal Article] Innovative preparation of curcumin for improved oral bioavailability (2011)
  • Author(s): Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya H, Fujita M, Hasegawa K, Morimoto T
  • Journal Title: Biol Pharm Bull Volume: 34(5) Pages: 660-665
  • NAID: 130000657776
• [Journal Article] Efficacy of RAD001(everolimus) against advanced gastric cancer with peritoneal dissemination (2011)
  • Author(s): Taguchi F, Kodera Y, Katanasaka Y, Yanagihara K, Tamura T, Koizumi. F
  • Journal Title: Invest New Drugs Volume: 29(6) Pages: 1198-205
• [Journal Article] Efficacy of RAD001 (everolimus) against advanced gastric cancer with peritoneal dissemination (2011)
  • Author(s): Taguchi F, Kodera Y, Katanasaka Y, Yanagihara K, Tamura T, Koizumi F
  • Journal Title: Invest New Drugs Volume: 29 Issue: 6 Pages: 1198-205
  • DOI: 10.1007/s10637-010-9464-9
  • Peer Reviewed
• [Journal Article] A natural p300-specific histone acetyltransferase inhibitor, curcumin, in addition to angiotensin-converting enzyme inhibitor, exerts beneficial effects on left ventricular systolic function after myocardial infarction in rats (2011)
  • Author(s): Sunagawa, Y, Morimoto, T, Wada, H, Takaya, T, Katanasaka, Y, Kawamura, T, Yanagi, S, Marui, A, Sakata, R, Shimatsu, A, Kimura, T, Kakeya, H, Fujita, M, Hasegawa, K
  • Journal Title: Circ J Volume: 75 Pages: 2151-9
  • NAID: 10029339526
  • Peer Reviewed
• [Journal Article] Sunitinib inhibits lymphatic endothelial cell functions and lymph node metastasis in a breast cancer model through inhibition of vascular endothelial growth fact or receptor 3 (2011)
  • Author(s): Kodera Y, Katanasaka Y, Kitamura Y, Tsuda H, Nishio K, Tamura T, Koizumi F
  • Journal Title: Breast Cancer Res Volume: 13 Issue: 3
  • DOI: 10.1186/bcr2903
  • Peer Reviewed
• [Presentation] NCoR/SMRT複合体によるp300/GATA4転写経路抑制機構の解析 (2012)
  • Author(s): 刀坂泰史、鈴木秀敏、並木雅俊、砂川陽一、廣田翔、和田啓道、島津章、藤田正俊、長谷川浩二、森本達也
  • Organizer: 第132回日本薬学会年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-29
• [Presentation] NCoR/SMRT複合体によるp300/GATA4転写経路抑制機構の解析 (2012)
  • Author(s): 刀坂泰史
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-29
• [Presentation] Protein Arginine Methyltransferase 5 and Methylosome Protein 50 Suppressies Hypertrophic Responses in Cardiomyocytes by Inhibition of p300/GATA4 Pathway (2011)
  • Author(s): Yasufumi Katanasaka, Yukiko Nakagawa, Yoichi Sunagawa, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: American Heart Association Scientific sessions 2011
  • Place of Presentation: Orland, USA
  • Year and Date: 2011-11-13
• [Presentation] Protein Arginine Methyltransferase 5 and Methylosome 50 suppresses hyperrophic responses in cardiomyopcytes by inhibition of p300/GATA4 pathway (2011)
  • Author(s): Yasufumi Katanasaka
  • Organizer: American Heart Association Scientific sessions 2011
  • Place of Presentation: Orland, USA
  • Year and Date: 2011-11-13
• [Presentation] Protein arginine ethyltransferase 5 suppresses hypertrophic gene transcription in rat cardiomyocytes through the inhibition of p300/GATA4 pathway (2011)
  • Author(s): Yasufumi Katanasaka, Yukiko Nakagawa, Yoichi Sunagawa, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 7th Chica-Japan Cardiovascular Forum
  • Place of Presentation: Beijing, China
  • Year and Date: 2011-10-15
• [Presentation] Protein Arginine Methyltransferase 5 suppresses hypertrophic gene transcription in rat cardiomyocytes through the inhibition of p300/GATA4 pathway (2011)
  • Author(s): Yasufumi Katanasaka
  • Organizer: The 7^<th> China-Japan Cardiovascular Forum
  • Place of Presentation: 北京,中国
  • Year and Date: 2011-10-15
• [Presentation] Protein arginine methyltransferase 5 and methylosome 50 are novel component of p300/GATA4 complex involved in hypertrophic responses in cardiac myocytes (2011)
  • Author(s): Yasufumi Katanasaka
  • Organizer: American Heart Association BCVS 2011
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2011-07-21
• [Presentation] Protein arginine metyltransferase 5 and methylosome protein 50 are novel component of p300/GATA4 complex involved in hypertrophic responses in cardiac myocytes (2011)
  • Author(s): Yasufumi Katanasaka, Yukiko Nakagawa, Yoichi Sunagawa, Hiromichi Wada, Akira Shimatsu, Masatoshi Fujita, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: American Heart Association BCVS2011
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2011-07-20
• [Presentation] アルギニンメチルトランスフェラーゼPRMT5による心筋細胞肥大反応の抑制 (2011)
  • Author(s): 刀坂泰史
  • Organizer: 第57回日本薬学会東海支部総会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-09
• [Presentation] Protein arginine metyltransferase 5 and methylosome protein 50 are novel component of p300/GATA4 complex involved in hypertrophic responses in cardiac myocytes (2011)
  • Author(s): Yasufumi Katanasaka, Yukiko Nakagawa, Yoichi Sunagawa, Masatoshi Fujita, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
  • Organizer: The 14 th Annual International Tronto Heart Summit
  • Place of Presentation: Tronto, Canada
  • Year and Date: 2011-06-09
• [Presentation] 新規GATA4結合タンパク質RbAp46、RbAp48の心筋細胞肥大への影響 (2010)
  • Author(s): 刀坂泰史、寺田太士、砂川陽一、渡辺雄一、高谷智英、和田啓道、島津章、木村剛、藤田正俊、長谷川浩二、森本達也
  • Organizer: 第18回日本血管生物医学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-01
• [Presentation] Combination therapy of gefitinib and a novel phosphatidyl inositol-3 kinase inhibitor BGT226 in non small cell lung cancer (2010)
  • Author(s): 刀坂泰史、温泉川真由、北村悠香、森本達也、小泉史明
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] 5-HT2A受容体拮抗薬サルポグレラートはフェニレフリンによって誘導される心筋細胞肥大を抑制する (2010)
  • Author(s): 刀坂泰史、村井範之、砂川陽一、川口正悟、矢吹晴一郎、和田啓道、木村剛、藤田正俊、長谷川浩二、森本達也
  • Organizer: 第1回Molecular Cardiovascular Conference II
  • Place of Presentation: 北海道
  • Year and Date: 2010-09-05