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Effects of BMP2 and FGF2 on the odontoblast differentiation and the induction methods of expression of cell function for the regeneration of dental pulp.

Research Project

Project/Area Number 22890167
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionKyushu Dental College

Principal Investigator

WASHIO Ayako  九州歯科大学, 歯学部歯学科, 助教 (10582786)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,977,000 (Direct Cost: ¥2,290,000、Indirect Cost: ¥687,000)
Fiscal Year 2011: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords象牙質・歯髄複合体 / 再生医療
Research Abstract

We examined the effects of Bone Morphogenic Protein-2(BMP-2) and Fibroblast Growth Factor-2(FGF-2), on the odontoblast differentiation of KN-3 cells, a cell line that we established from dental pulp. Our results indicate that BMP-2 and FGF-2 play critical roles in induction of the odontoblast properties of KN-3 cells via activation of Smad and ERK signaling pathways, respectively. We could have useful knowledge about the establishment of wound healing and local regeneration of dentin-pulp complex.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (8 results)

All 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] Possible Involvement of Smad Signaling Pathways in Induction of Odontoblastic Properties in KN-3 Cells by Bone Morphogenetic Protein-2, a Growth Factor to Induce Dentin Regeneration2012

    • Author(s)
      Ayako Washio、Chiaki Kitamura、Takahiko Morotomi
    • Journal Title

      International Journal of Dentistry

      Volume: VOL. 2012 Pages: 1-6

    • DOI

      10.1155/2012/258469

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Local regeneration of dentin-pulp complex using controlled release of FGF-2 and naturally derived sponge-like scaffolds.2012

    • Author(s)
      Kitamura C, Nishihara T, Terashita M, Tabata Y, Washio A
    • Journal Title

      International Journal of Dentistry

      Volume: volume2012 Pages: 8-8

    • DOI

      10.1155/2012/190561

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration approach for dental pulp and periapical tissues with growth factors, biomaterials, and laser irradiation. Special issue "Polymers for Oro-Dental and Cranio-Maxillo-Facial Applications"2011

    • Author(s)
      Chiaki Kitamura、Tatusji Nishihara、Ayako Washio
    • Journal Title

      Polymers

      Volume: 3(4) Pages: 1776-1793

    • Related Report
      2011 Final Research Report
  • [Presentation] FGF-2は象牙芽細胞様細胞の形態変化を誘導する2011

    • Author(s)
      鷲尾絢子
    • Organizer
      第9回日本再生歯科医学学術大会・総会
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 象牙芽細胞分化に及ぼすFGF-2の影響2011

    • Author(s)
      鷲尾絢子
    • Organizer
      第32回日本歯内療法学会学術大会
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] FGF-2が象牙芽細胞様細胞に及ぼす影響2011

    • Author(s)
      鷲尾絢子
    • Organizer
      第134回日本歯科保存学会
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 象牙芽細胞様細胞の分化におけるFGF-2の影響2011

    • Author(s)
      鷲尾絢子
    • Organizer
      第71回九州歯科学会総会
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 象牙芽細胞様細胞の分化におけるBMP-2の影響2010

    • Author(s)
      鷲尾絢子
    • Organizer
      九州歯科学会総会記念学会
    • Place of Presentation
      九州歯科大学(北九州)
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-27   Modified: 2016-04-21  

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