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Novel imaging analytical method for measuring the stimulus-induced activity of the cranial nerves

Research Project

Project/Area Number 22890168
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Prosthetic dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

KONO Mai  北海道医療大学, 歯学部, 助教 (90586926)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,795,000 (Direct Cost: ¥2,150,000、Indirect Cost: ¥645,000)
Fiscal Year 2011: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2010: ¥1,534,000 (Direct Cost: ¥1,180,000、Indirect Cost: ¥354,000)
Keywords脳神経活動 / 咀嚼機能 / MRI / MEMRI / 咀嚼 / 咬合不全 / MEMRI信号
Research Abstract

In this study, we examined the hypothesis that manganese-enhaced MRI(MEMRI) can detect the effect of physiological and unphysiologocal occlusal force on the behavior of magnesium ion in the brain. As a first step, we investigated the time-dependent change in brain distribution of injected magnesium ion. The high signal intensity was observed in lateral cerebral ventricle and hippocampus at 1 hour post-injection. The signal of magnesium ion was consistently until 6 hours after administration. Next, rats forget for food immediately after administration to examine the effect of chewing on the signal intensity. However, MEMRI can not detect the change in the signal intensity due to the restricted voluntary chewing. It seemed that the toxic side-effect of magnesium reduced food intake and spontaneous activity.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (2 results)

All 2012

All Presentation (2 results)

  • [Presentation] 咀嚼刺激による脳内活動部位検出のための脳機能イメージング法の検討2012

    • Author(s)
      河野舞、川西克弥、會田英紀、豊下祥史、越野寿
    • Organizer
      北海道医療大学歯学会第30回学術大会
    • Place of Presentation
      札幌(北海道医療大学サテライトキャンパス)
    • Year and Date
      2012-03-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 咀嚼刺激による脳神経活動部位検出のための脳機能イメージング法の検討2012

    • Author(s)
      河野舞
    • Organizer
      北海道医療大学歯学会第30回学術大会
    • Place of Presentation
      札幌(北海道医療大学札幌サテライトキャンパス)
    • Year and Date
      2012-03-03
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-27   Modified: 2016-04-21  

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