| Project/Area Number |
22890175
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
SUGAWARA Akihiro 北里大学, 大学院・感染制御科学府, 助教 (50581683)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,704,000 (Direct Cost: ¥2,080,000、Indirect Cost: ¥624,000)
Fiscal Year 2011: ¥1,209,000 (Direct Cost: ¥930,000、Indirect Cost: ¥279,000)
Fiscal Year 2010: ¥1,495,000 (Direct Cost: ¥1,150,000、Indirect Cost: ¥345,000)
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| Keywords | シスデカリン / トリシクロ[5.3.1.^<1, 7> 0^<3, 8>]ウンデカン / ルミナミシン / 抗嫌気性菌活性 / 全合成 / 構造活性相関 / マクロライド / 酸素結束シスデカリン / エノールエーテル / オキサトリシクロウンデカン / 共役14員環エノールエーテル / 抗菌活性のスイッチング |
|---|
| Research Abstract |
An efficient synthesis of the key framework of luminamicin, possessing vinyl enol ether, utilizing Stille coupling and Shiina macrolactonization was achieved. Additionally, synthesis of 11-oxatricyclo[5.3.1.^<1, 7> 0^<3, 8>] undecane framework, utilizing cascade Michael-aldol reaction and reaction of oxidative enol etherification was also developed.
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