| Project/Area Number |
22890177
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
SHIOHAMA Aiko Keio University, 医学部, 助教 (40383731)
|
|---|
| Project Period (FY) |
2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
|
|---|
| Keywords | アトピー性皮膚炎 / モデルマウス / ゲノムシーケンシング / 遺伝子多型 / フィラグリン |
|---|
| Research Abstract |
Flaky tail mouse (ft^-・ma^-/ft^-・ma^-) is a model of atopic dermatitis, however, we found that both of matted coat (ma) and elevated IgE sensitization are not phenotype for filaggrin deficiency (ft^-). To identify responsible gene for these phenotypes, we established polymorphic markers and narrowed the ma responsible region within 3.7 Mb. Finally, we established ft (ft^-・ma^+/ft^-・ma^+) and ma (ft^+・ma^-/ft^+・ma^-) mice strains by backcrossed recombination which was evaluated by our established polymorphic markers.
|
