Social brain function deficits and psychosis in schizophrenia and Asperger's disorder

• Project/Area Number: 22890179
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Showa University
• Principal Investigator: HASHIMOTO Ryuichiro 昭和大学, 医学部, 講師 (00585838)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000); Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000); Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
• Keywords: 統合失調症 / 自閉症スペクトラム障害 / 社会機能 / 幻聴 / 言語 / 選択的注意 / 流動性知能 / fMRI / アスペルガー症候群 / 脳神経疾患

Research Abstract

Using functional magnetic resonance imaging(fMRI), I conducted a series of experiments that aimed to identify deficient neural cognitive mechanisms that underlie social and communicative problems in schizophrenia and autism spectrum disorders(ASD), including Asperger's disorder. In experiments for schizophrenia, we identified multiple levels of functional abnormalities in the auditory language system that underlie auditory hallucinations. In experiments for ASD, we revealed significant association between deficiency of selective attention and the severity of ASD symptoms. These findings help to identify critical neural abnormalities responsible for schizophrenia and ASD, each of which is characterized by social and communicative deficits.

Research Products

• [Journal Article] An fMRI Study of Reduced Perceptual Load-dependent Modulation of Task-irrelevant Activity in Adults with Autism Spectrum Conditions (2012)
  • Author(s): Ohta, H., Yamada, T., Watanabe, H., Kanai, C., Tanaka, E., Ohno, T., Takayama, Y., Iwanami, A., Kato, N., Hashimoto, R.
  • Journal Title: Neuroimage Volume: 61(4) Pages: 1176-1187
• [Journal Article] An fMRI study of reduced perceptual load-dependent modulation of task-irrelevant activity in adults with autism spectrum conditions (2012)
  • Author(s): H.Ohta, T.Yamada, H.Watanabe, C.Kanai, E.tanaka, T.Ohno, Ytakayama, A.Iwanami, N.Kato, R.Hashimoto
  • Journal Title: Neuroimage Volume: (印刷中) Issue: 4 Pages: 1176-1187
  • DOI: 10.1016/j.neuroimage.2012.03.042
  • Peer Reviewed
• [Journal Article] A Voxel-Based Morphometry Study of Gray Matter Loss in Fragile X-Associated Tremor/Ataxia Syndrome
  • Author(s): Hashimoto, et al.
  • Journal Title: Brain Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Diffusion Tensor Imaging in Male Premutation Carriers of the Fragile X Mental Retardation Gene
  • Author(s): Hashimoto, et al.
  • Journal Title: Movement Disorders Volume: (印刷中)
  • Peer Reviewed
• [Presentation] An fMRI Study of Selective Attention Deficits in Adult Autism Spectrum Disorder (2011)
  • Author(s): R.Hashimoto, et al
  • Organizer: The 17th Annual Meeting of the organization on Human Brain Mapping
  • Place of Presentation: ケベック、カナダ
  • Year and Date: 2011-06-27
• [Presentation] 自閉症スペクトラム障害における選択的注意の障害の脳基盤 (2011)
  • Author(s): 太田晴久、橋本龍一郎、山田貴志、谷将之、金井智恵子、大野泰正、高山裕子、長谷川澄、岩波明、加藤進晶
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京
• [Presentation] 幻聴に対する治療効果を反映する脳機能指標の計測:機能的MRIを用いた検討 (2011)
  • Author(s): 長谷川澄・三村将・谷将之・吉村直紀・大野泰正・高山裕子・山田貴志・太田晴久・加藤進晶・橋本龍一郎
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京
• [Presentation] 自閉症スペクトラム障害における流動性知能課題施行時の脳活動: fMRIによる検討 (2011)
  • Author(s): 山田貴志、橋本龍一郎、太田晴久、金井智恵子、谷将之、渡部洋実、大野泰正、高山裕子、岩波明、加藤進晶
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京
• [Presentation] The neural basis of selective attention deficits in autism spectrum disorder (2011)
  • Author(s): Ota H., Hashimoto R., Yamada T., Tani M., Takayama Y., Ohno T., Iwanami A., & Kato N.
  • Organizer: The 10th World Congress of Biological Psychiatry
  • Place of Presentation: プラハ,チェコ共和国
• [Presentation] Neural basis of fluid intelligence in autism spectrum disorder (2011)
  • Author(s): Yamada T., Hashimoto R., Ohta H., Watanabe H., Tani M., Kanai C., Mimura O., Iwanami A., & Kato N.
  • Organizer: The 10th World Congress of Biological Psychiatry
  • Place of Presentation: プラハ,チェコ共和国
• [Presentation] An fMRI Study of Selective Attention Deficits in Adult Autism Spectrum Disorder (2011)
  • Author(s): Hashimoto, R., Ohta, H., Yamada T., Mimura M., Iwanami A., Kato, N.
  • Organizer: The 17th Annual Meeting of the organization on Human Brain Mapping
  • Place of Presentation: ケベック,カナダ
• [Presentation] The neural basis of selective attention deficits in autism spectrum disorder (2011)
  • Author(s): Ohta H., Hashimoto R., Yamada T., Tani M., Watanabe H., Kanai C., Ohno T., Takayama Y., Iwanami A., & Kato N.
  • Organizer: Society for Neuroscience 2011
  • Place of Presentation: ワシントンDC,アメリカ
• [Presentation] Neural basis of fluid intelligence in autism spectrum disorder (2011)
  • Author(s): Yamada T., Hashimoto R., Ohta H., Watanabe H., Yamada T., Ohno T., Takayama Y., Tani M., Iwanami A., & Kato N.
  • Organizer: Society for Neuroscience 2011
  • Place of Presentation: ワシントンDC,アメリカ
• [Presentation] FMR1遺伝子変異の神経画像研究 (2010)
  • Author(s): 橋本龍一郎
  • Organizer: 第40回日本臨床神経生理学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-02
• [Book] 前頭葉でわかる精神疾患の臨床 (2010)
  • Author(s): 橋本龍一郎
  • Total Pages: 8
  • Publisher: 中山書店
• [Book] 抗精神病薬の脳構造、脳機能に及ぼす影響,向精神薬のリスク・ベネフィット(「専門医のための精神科臨床リュミエール25」)
  • Author(s): 夏堀龍暢・八幡憲明・井上秀之・橋本龍一郎・笠井清登
  • Publisher: 中山書店