Social brain function deficits and psychosis in schizophrenia and Asperger's disorder
| Project/Area Number |
22890179
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
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| Keywords | 統合失調症 / 自閉症スペクトラム障害 / 社会機能 / 幻聴 / 言語 / 選択的注意 / 流動性知能 / fMRI / アスペルガー症候群 / 脳神経疾患 |
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| Research Abstract |
Using functional magnetic resonance imaging(fMRI), I conducted a series of experiments that aimed to identify deficient neural cognitive mechanisms that underlie social and communicative problems in schizophrenia and autism spectrum disorders(ASD), including Asperger's disorder. In experiments for schizophrenia, we identified multiple levels of functional abnormalities in the auditory language system that underlie auditory hallucinations. In experiments for ASD, we revealed significant association between deficiency of selective attention and the severity of ASD symptoms. These findings help to identify critical neural abnormalities responsible for schizophrenia and ASD, each of which is characterized by social and communicative deficits.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] An fMRI Study of Reduced Perceptual Load-dependent Modulation of Task-irrelevant Activity in Adults with Autism Spectrum Conditions2012
Author(s)
Ohta, H., Yamada, T., Watanabe, H., Kanai, C., Tanaka, E., Ohno, T., Takayama, Y., Iwanami, A., Kato, N., Hashimoto, R.
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Journal Title
Neuroimage
Volume: 61(4)
Pages: 1176-1187
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[Presentation] The neural basis of selective attention deficits in autism spectrum disorder2011
Author(s)
Ohta H., Hashimoto R., Yamada T., Tani M., Watanabe H., Kanai C., Ohno T., Takayama Y., Iwanami A., & Kato N.
Organizer
Society for Neuroscience 2011
Place of Presentation
ワシントンDC,アメリカ
Related Report
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[Presentation] Neural basis of fluid intelligence in autism spectrum disorder2011
Author(s)
Yamada T., Hashimoto R., Ohta H., Watanabe H., Yamada T., Ohno T., Takayama Y., Tani M., Iwanami A., & Kato N.
Organizer
Society for Neuroscience 2011
Place of Presentation
ワシントンDC,アメリカ
Related Report
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