| Project/Area Number |
22890180
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Showa University |
|---|
Principal Investigator |
SUZUKI Dai 昭和大学, 歯学部, 助教 (00585797)
|
|---|
| Research Collaborator |
KAMIJO Ryutaro 昭和大学, 歯学部, 教授 (70233939)
YAMADA Atsushi 昭和大学, 歯学部, 講師 (50407558)
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|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,977,000 (Direct Cost: ¥2,290,000、Indirect Cost: ¥687,000)
Fiscal Year 2011: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 遺伝子 / 発生・分化 / 細胞・組織 / 骨・軟骨 |
|---|
| Research Abstract |
Rac1, a member of the Rho subfamily of small GTPases, is known to be a regulator of multiple cellular functions, including cytoskeletal organization, cell migration, proliferation, and apoptosis. To investigate the physiological function of Rac1 during bone and cartilage formation, we generated tissue-specific inactivated Rac1(Rac1fl/fl ; Prx1-Cre) mice. Rac1 conditional knockout mice demonstrated short limbs and incomplete fusions of the cranium. Our results infer that short limb was caused by abnormal endochondral ossification and incomplete fusion of the cranium was due to enhanced mineralization.
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