Functions of Rac1 during bone and cartilage formation
| Project/Area Number |
22890180
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
SUZUKI Dai 昭和大学, 歯学部, 助教 (00585797)
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| Research Collaborator |
KAMIJO Ryutaro 昭和大学, 歯学部, 教授 (70233939)
YAMADA Atsushi 昭和大学, 歯学部, 講師 (50407558)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,977,000 (Direct Cost: ¥2,290,000、Indirect Cost: ¥687,000)
Fiscal Year 2011: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 遺伝子 / 発生・分化 / 細胞・組織 / 骨・軟骨 |
|---|
| Research Abstract |
Rac1, a member of the Rho subfamily of small GTPases, is known to be a regulator of multiple cellular functions, including cytoskeletal organization, cell migration, proliferation, and apoptosis. To investigate the physiological function of Rac1 during bone and cartilage formation, we generated tissue-specific inactivated Rac1(Rac1fl/fl ; Prx1-Cre) mice. Rac1 conditional knockout mice demonstrated short limbs and incomplete fusions of the cranium. Our results infer that short limb was caused by abnormal endochondral ossification and incomplete fusion of the cranium was due to enhanced mineralization.
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Report
(3 results)
Research Products
(45 results)
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[Journal Article] Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development2011
Author(s)
Aizawa R, Yamada A, Suzuki D, Iimura T, Kassai H, Harada T, Tsukasaki M, Yamamoto G, Tachikawa T, Nakao K, Yamamoto M, Yamagchi A, Aiba A, Kamijo R
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Journal Title
AMech Dev
Volume: (In press)
Issue: 1-4
Pages: 38-50
DOI
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Peer Reviewed
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[Presentation] BMP活性制御因子の探索とその機能解析2011
Author(s)
山田篤, 塚崎雅之, 鈴木大, 相澤怜, 宮園あがさ, 山本松男, 上條竜太郎
Organizer
昭和大学大学院歯学研究科・口腔癌包括的研究センター平成22年度合同シンポジウム
Place of Presentation
東京
Year and Date
2011-03-26
Related Report
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[Presentation] Essential role of Cdc42 in chondrogenesis and interdigital programmed cell death during limb development2011
Author(s)
Ryo Aizawa, Atsushi Yamada, Dai Suzuki, Hidetoshi Kassai, Takeshi Harada, Masayuki Tsukasaki, Gou Yamamoto, Tadahiro Iimura, Akira Yamaguchi, Kazuki Nakao, Matsuo Yamamoto, Atsu Aiba, Ryutaro Kamijo
Organizer
The 33th Annual Meeting of the American Society for Bone and Mineral Research
Place of Presentation
San Diego, California, USA
Related Report
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[Presentation] TNF-α Suppresses POEM Expression in Osteoblasts2011
Author(s)
Tsukasaki M, Yamada A, Miyazono A, Suzuki D, Yoshimura K, Aizawa R, Miyamoto Y, Takami M, Suzawa T, Morimura N, Aruga J, Yamamoto M, Kamijo R
Organizer
89th General Session & Exhibition of the International Associate for Dental Research(IADR)
Place of Presentation
San Diego, California, USA
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[Presentation] Alx3, a Paired-type Homeodomein Containing Transcription Factor, Regulates Osteoblast Differentiation Induced by BMP-22010
Author(s)
Matsumoto T, Yamada A, Suzuki D, Takami M, Suzawa T, Miyamoto Y, Baba K, Kamijo R
Organizer
The 32nd Annual Meeting of the American Society for Bone and Mineral Research
Place of Presentation
Toronto, Canada
Related Report
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