Elucidation of the role of monocarboxylate transporters on chondrocytes' degenerative change of joint desease
Project/Area Number |
22890181
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Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Functional basic dentistry
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Research Institution | Showa University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥2,977,000 (Direct Cost: ¥2,290,000、Indirect Cost: ¥687,000)
Fiscal Year 2011: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 口腔生化学 / 軟骨変性疾患 / MCT-1 / IL-1β / 活性酸素種 / NOX-2 / 軟骨 / 遺伝子発現 / 炎症性疾患 / シグナル伝達 |
Research Abstract |
Interleukin-1β(IL-1β) induces cell death in chondrocytes in a nitric oxide(NO)-and reactive oxygen species(ROS)-dependent manner. In this study, increased production of lactate was observed in IL-1β-treated mouse chondrocytic ATDC5 cells prior to the onset of their death. IL-1β-induced cell death in ATDC5 cells was suppressed by introducing an siRNA for monocarboxylate transporter-1(MCT-1), a lactate transporter distributed in plasma and mitochondrial inner membranes.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-α2011
Author(s)
Tsukasaki M, Yamada A, Suzuki D, Aizawa R, Miyazono A, Miyamoto Y, Suzawa T, Takami M, Yoshimura K, Morimura N, Yamamoto M, Kamijo R
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Journal Title
Biochem Biophys Res Commun
Volume: 410
Pages: 766-770
Related Report
Peer Reviewed
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[Journal Article] Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1. via activation of nuclear factor-. B and expression of phagocyte-type NADPH-oxidase2011
Author(s)
Yoshimura K, Miyamoto Y, Yasuhara R, Maruyama T, Akiyama T, Yamada A, Takami M, Suzawa T, Tsunawaki S, Tachikawa T, Baba K, Kamijo R
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Journal Title
J Biol Chem
Volume: 286
Pages: 14744-14752
Related Report
Peer Reviewed
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