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Does the podocyte damage is non-invertible? Inquest therapeutic modality for the damage.

Research Project

Project/Area Number 22890196
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionThe University of Tokyo (2011)
Teikyo University (2010)

Principal Investigator

WATANABE Sumiyo  東京大学, 大学院・医学系研究科, 特任研究員 (30422314)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
Keywords慢性腎不全 / 腎足細胞 / p130-Cas / 遺伝子治療 / ナノキャリア / p130-cas / cas L / アルブミン尿 / ナノキャリアー / 腎不全 / 足細胞 / 足細胞特異的p130-casノックアウト
Research Abstract

Brief overview : This theme is focused on the point that'' podocyte has the same signal transduction as skeletal muscle to the extent of existing actin signal pathway''. The skeletal muscle tissue and renal podocyte have a common pathway, it means that podocyte damage can be healed as muscle skeletal damage though the accepted notion of nowadays is that'' podocyte damage is never recovered''. We made podocyte damage mice. We will try to cure their renal function by'' genetic manipulation nanocarrier'' which have been developed by ourselves.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results) Book (3 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles2012

    • Author(s)
      F. Pittella, K. Miyata
    • Journal Title

      J. Control.Release

      Volume: 161 Issue: 3 Pages: 868-874

    • DOI

      10.1016/j.jconrel.2012.05.005

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct and Instantaneous Observation of Intravenously Injected Substances Using Intravital Confocal Micro-Videography2010

    • Author(s)
      Y. Matsumoto, S. Watanabe et. al.
    • Journal Title

      Biomed. Opt. Express

      Volume: 1(4) Pages: 1209-1216

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed?term=Direct%20and%20Instantaneous%20Observation%20of%20Intravenously%20Injected%20Substances%20Using%20Intravital%20Confocal%20Micro-Videography

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct and Instantaneous Observation of Intravenously Injected Substances Using Intravital Confocal Micro-Videography2010

    • Author(s)
      Matsumoto Y, Watanabe S, et al.
    • Journal Title

      Biomed.Opt.Express

      Volume: 1 Pages: 1209-1216

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ポリカチオン構造の精密設計に基づいたポリイオンコンプレックス封入siRNA分子数の制御2012

    • Author(s)
      茶谷洋行、渡邉秀美代et. al
    • Organizer
      第61回高分子学会年次大会
    • Place of Presentation
      パシフィコ横浜、神奈川県横浜市
    • Year and Date
      2012-05-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Preparation of polyion complexes incorporating the regulated number of siRNA molecules by fine-tuning of polycationic structures2012

    • Author(s)
      Chaya H, Watanabe S et. al
    • Organizer
      Softinterface International Mini-Symposium on Biointerface-Interface between Bio and Materials
    • Place of Presentation
      つくば国際会議場、茨城県筑波市
    • Year and Date
      2012-03-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Preparation of polyion complexes incorporating the regulated number of siRNA molecules by fine-tuning of polycationic structures2012

    • Author(s)
      Chaya H, Watanabe S, et al
    • Organizer
      Softinterface International Mini-Symposium on Biointerface-Interface between Bio and Materials
    • Place of Presentation
      茨城県筑波大学
    • Year and Date
      2012-03-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Intravital Real-Time Confocal Microangiography2010

    • Author(s)
      Matsumoto Y, Watanabe S, et al.
    • Organizer
      The Third International NanoBio Conference
    • Place of Presentation
      ETH Zurich, Zurich
    • Year and Date
      2010-08-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖尿病性腎症に合併した溶連菌感染後急性糸球体腎炎の一例2010

    • Author(s)
      久保英二、渡邉秀美代, 他
    • Organizer
      日本腎臓学会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2010 Annual Research Report
  • [Book] 症候群ハンドブック2011

    • Author(s)
      渡邉秀美代、内田俊也、編集:福井次矢/辻省次,総編集:井村裕夫
    • Total Pages
      792
    • Publisher
      中山書店
    • Related Report
      2011 Final Research Report
  • [Book] 症候群ハンドブック2011

    • Author(s)
      渡邉秀美代、内田俊也
    • Publisher
      中山書店
    • Related Report
      2011 Annual Research Report
  • [Book] 症候群ハンドブック2011

    • Author(s)
      井村裕矢, 他(渡邉秀美代 含む)
    • Total Pages
      757
    • Publisher
      中山書店
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.bmw.t.u-tokyo.ac.jp/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.bmw.t.u-tokyo.ac.jp/index.html

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 核酸デリバリー様ユニット構造体2012

    • Inventor(s)
      片岡一則、渡邉秀美代, 他6名
    • Industrial Property Rights Holder
      片岡一則、渡邉秀美代, 他6名
    • Filing Date
      2012-04-27
    • Related Report
      2011 Final Research Report
    • Overseas

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Published: 2010-08-27   Modified: 2016-04-21  

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