| Budget Amount *help |
¥2,912,000 (Direct Cost: ¥2,240,000、Indirect Cost: ¥672,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,443,000 (Direct Cost: ¥1,110,000、Indirect Cost: ¥333,000)
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| Research Abstract |
Abnormally increased mechanical load due to varus deformity is associated with cartilage degradation in the medial condyle. Interestingly, the tissue damage caused by mechanical stress activates a cellular response that leads to proliferation of STRO-1positive progenitor cells and cluster formation. On the other hand, thick non-degenerated cartilage in the lateral compartment that experiences reduced load due to varus deformity shows low-density single chondrocytes that appear to have reduced proliferative and biosynthetic activity. Appropriate mechanical stress appears critical for maintaining cartilage homeostasis and early restoration of normal mechanical load in both compartments of the knee may prevent cell and tissue damage.
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