| Budget Amount *help |
¥2,847,000 (Direct Cost: ¥2,190,000、Indirect Cost: ¥657,000)
Fiscal Year 2011: ¥1,261,000 (Direct Cost: ¥970,000、Indirect Cost: ¥291,000)
Fiscal Year 2010: ¥1,586,000 (Direct Cost: ¥1,220,000、Indirect Cost: ¥366,000)
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| Research Abstract |
Epithelial cells surround mammalian organs and tissues and epithelial cell sheets constitute the principal barrier to cellular uptake and transport. The tight junction(TJ) plays a pivotal role as both a barrier to restrict various substances, such as pathogens, toxins, and allergens. In this study, we screened the chemical substances to disruption of barrier function and disturbance of immune system in environment and food. It was observed that various environmental pollutants were decreased barrier function of TJ. Furthermore, we observed that treatment of mice with dioxins and antigen results in significant elevation antigen-specific immunoglobulin production in a dose-dependent manner. There results suggest the chemical substance in environment and food dysregulates the barrier function and immune system.
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