| Budget Amount *help |
¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
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| Research Abstract |
IL-33 is a newly identified IL-1 family cytokine, which stimulates basophile, mast cell, dendritic cell or T cell to augment Th2 response and exacerbate allergic diseases. Recent studies have revealed not only cleaved, so called"mature-form", but also full length, so called"pre-form", IL-33 has its biological activity suggesting the importance of IL-33 up-regulation itself in the initiation or exacerbation of allergic diseases. However, the mechanisms for IL-33 induction are yet to be fully uncovered. Here, we studied the regulatory mechanisms of IL-33 protein and mRNA expression in Ragweed pollen induced allergic rhinitis and asthma mouse model. Further more, to gain insight into the precise regulatory mechanisms for IL-33 mRNA expression in the epithelial cells, we investigated Ragweed pollen and PMA and ionomycin induced IL-33 mRNA expression in human bronchial epithelial cell line, BEAS-2B.
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