The production of NG2 (+) cell conditional dysfunction mice for purposes of elucidation of schizophrenia.

• Project/Area Number: 22890239
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TOYOSHIMA Manabu The Institute of Physical and Chemical Research, 分子精神科学研究チーム, 研究員 (90582750)
• Project Period (FY): 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000); Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
• Keywords: 統合失調症 / NG2(+)細胞 / FABP7

Research Abstract

We produced the NG2 (+) cell conditional dysfunction mice for purposes of elucidation of schizophrenia. About 50 % of NG2 (+) cells were impaired by tamoxifen treatment in the NG2 (+) cell conditional dysfunction mice.

Research Products

• [Journal Article] NG2陽性細胞(ポリデンドロサイト)と精神疾患 (2010)
  • Author(s): 吉川武男、豊島学、前川素子
  • Journal Title: 精神科 17 Pages: 401-406
• [Journal Article] Excessive ingestion of long chain polyunsaturated fatty acids during developmental stage causes strain and sex dependent eye abnormalities in mice. (2010)
  • Author(s): Maekawa M, Iwayama Y, Watanabe A, Nozaki Y, Ohnishi T, Ohba H, Toyoshima M, Hamazaki K, Osumi N, Aruga J, Yoshikawa T
  • Journal Title: Biochem Biophys Res Commun 402 Pages: 431-437
• [Journal Article] NG2陽性細胞(ポリデンドロサイト)と精神疾患 (2010)
  • Author(s): 吉川武男
  • Journal Title: 精神科 Volume: 17 Pages: 401-406
  • Peer Reviewed
• [Journal Article] Excessive ingestion of long-chain polyunsaturated fatty acids during developmental stage causes strain- and sex-dependent eye abnormalities in mice. (2010)
  • Author(s): Motoko Maekawa
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 402 Pages: 431-437
  • Peer Reviewed