Analysis of epigenetic changes which cause diabetes mellitus.-Interaction between epigenetic changes and nutritional adaptation systems-
| Project/Area Number |
22890244
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
UEBANSO Takashi 独立行政法人国立国際医療研究センター, 研究所・糖尿病研究センター・代謝疾患研究部, 研究員 (10581829)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
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| Keywords | 栄養学 / 糖尿病 / エピゲノム |
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| Research Abstract |
Interactions among diabetes, nutritional status and epigenetic modification are mysterious. First we assessed nutritional adaptation factors. We next investigated which nutritional adaptation factors or diabetic conditions affect epigenetic modification in pancreatic beta-cells. A metabolite which is regulated by nutritional status regulates epigenetic modification. This metabolite is synthesis by an enzyme which expression was dysregulated in diabetic animals. These results suggest that nutritional or diabetic conditions affect metabolic changes and epigenetic modifications.
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] Paradoxical Regulation of Human FGF21 by Both Fasting and Feeding Signals : Is FGF21 a Nutritional Adaptation Factor?2011
Author(s)
Uebanso T, Taketani Y, Yamamoto H, Amo K, Ominami H, Arai H, Takei Y, Masuda M, Tanimura A, Harada N, Yamanaka-Okumura H, Takeda E
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Journal Title
PLoS One
Volume: 6(8)
Issue: 8
Pages: 22976-22976
DOI
Related Report
Peer Reviewed
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