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Analysis of epigenetic changes which cause diabetes mellitus.-Interaction between epigenetic changes and nutritional adaptation systems-

Research Project

Project/Area Number 22890244
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionResearch Institute, International Medical Center of Japan

Principal Investigator

UEBANSO Takashi  独立行政法人国立国際医療研究センター, 研究所・糖尿病研究センター・代謝疾患研究部, 研究員 (10581829)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
Keywords栄養学 / 糖尿病 / エピゲノム
Research Abstract

Interactions among diabetes, nutritional status and epigenetic modification are mysterious. First we assessed nutritional adaptation factors. We next investigated which nutritional adaptation factors or diabetic conditions affect epigenetic modification in pancreatic beta-cells. A metabolite which is regulated by nutritional status regulates epigenetic modification. This metabolite is synthesis by an enzyme which expression was dysregulated in diabetic animals. These results suggest that nutritional or diabetic conditions affect metabolic changes and epigenetic modifications.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Paradoxical Regulation of Human FGF21 by Both Fasting and Feeding Signals : Is FGF21 a Nutritional Adaptation Factor?2011

    • Author(s)
      Uebanso T, Taketani Y, Yamamoto H, Amo K, Ominami H, Arai H, Takei Y, Masuda M, Tanimura A, Harada N, Yamanaka-Okumura H, Takeda E
    • Journal Title

      PLoS One

      Volume: 6(8) Issue: 8 Pages: 22976-22976

    • DOI

      10.1371/journal.pone.0022976

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 膵β細胞における、ケトン体代謝酵素BDH2の新規機能の解析2012

    • Author(s)
      上番増喬, 他
    • Organizer
      日本病態栄養学会年次学術集会
    • Place of Presentation
      京都
    • Year and Date
      2012-01-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 膵β細胞における、ケトン体代謝酵素BDH2の新規機能解析2012

    • Author(s)
      上番増喬,安田和基, 他5名
    • Organizer
      第15回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report

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Published: 2010-08-27   Modified: 2016-04-21  

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