| Budget Amount *help |
¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
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| Research Abstract |
We established porcine amniotic membrane, placenta and umbilical cord-derived mesenchymal cells. Their mesenchymal cells were expressed mesencymal stem cell markers, just as human cells. The cells transduced with enhanced green fluorescent protein(EGFP) were directly transplanted in injured myocardium on porcine chronic myocardial ischemic model. Injected allogeneic EGFP-expressing AMSCs were identified in the immunocompetent host heart without the use of any immunosuppressants at 4 weeks after transplantation. Immunohistochemistry revealed that EGFP colocalized with cardiac troponin T and cardiac troponin I.
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