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The assembly of an animal experimental model system for cell transplantation therapy using allogeneic stem cells with severe cardiac failure.

Research Project

Project/Area Number 22890249
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

ITAKURA Yoko  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (30582746)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
Keywords再生医学 / 心臓 / 大動物 / 評価 / 幹細胞移植 / 間葉系細胞 / 評価(糖鎖)
Research Abstract

We established porcine amniotic membrane, placenta and umbilical cord-derived mesenchymal cells. Their mesenchymal cells were expressed mesencymal stem cell markers, just as human cells. The cells transduced with enhanced green fluorescent protein(EGFP) were directly transplanted in injured myocardium on porcine chronic myocardial ischemic model. Injected allogeneic EGFP-expressing AMSCs were identified in the immunocompetent host heart without the use of any immunosuppressants at 4 weeks after transplantation. Immunohistochemistry revealed that EGFP colocalized with cardiac troponin T and cardiac troponin I.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2011 2010 Other

All Presentation (4 results) Remarks (2 results)

  • [Presentation] 糖鎖プロファイル解析を利用した細胞移植療法に適した組織環境評価2011

    • Author(s)
      板倉陽子、上大介、五條理志、梅澤明弘、豊田雅士
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ブタ慢性心筋虚血モデルへの同種ブタ羊膜由来細胞移植2011

    • Author(s)
      木村光利、五條理志、豊田雅士、板倉陽子、許俊鋭、梅澤明弘、小野稔
    • Organizer
      第11回心血管再生先端治療フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 再生医療へ向けた細胞表層糖鎖を用いた幹細胞評価技術の開発-レクチンマイクロアレイによる糖鎖プロファイル解析の利用2010

    • Author(s)
      板倉陽子、久野敦、高橋順子、五條理志、許俊鋭、梅澤明弘、平林淳、豊田雅士
    • Organizer
      日本人工臓器学会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2010-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 再生医療へ向けた細胞表層糖鎖を用いた幹細胞評価技術の開発-レクチンマイクロアレイによる糖鎖プロファイル解析の利用-2010

    • Author(s)
      板倉陽子
    • Organizer
      日本人工臓器学会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmig.or.jp/J_TMIG/j_research/DA31.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmig.or.jp/J_TMIG/j_research/DA31.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-27   Modified: 2016-04-21  

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