| Budget Amount *help |
¥41,600,000 (Direct Cost: ¥32,000,000、Indirect Cost: ¥9,600,000)
Fiscal Year 2024: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2023: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2022: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
This study elucidated a novel pathway in which the ESCRT-I complex and PTPN23 mediate the intracellular degradation of the abnormal tau protein associated with Alzheimer’s disease. In addition, age-dependent brain proteins were identified through proteomic analysis, and their abnormal accumulation and localization were shown to potentially affect neural function. These findings enhance our understanding of the molecular basis of neurodegenerative diseases and age-related cognitive decline, and may contribute to the development of new diagnostic and therapeutic strategies.
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