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オルガノイドデザインによる臓器創出と移植による全身制御

Research Project

Project/Area Number 22H00472
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 53:Organ-based internal medicine and related fields
Research InstitutionJuntendo University (2024)
Tokyo Medical and Dental University (2022-2023)

Principal Investigator

渡辺 守  順天堂大学, 大学院医学研究科, 特任教授 (10175127)

Co-Investigator(Kenkyū-buntansha) 油井 史郎  東京医科歯科大学, 統合研究機構, 准教授 (00383886)
伊藤 剛  東京医科歯科大学, 大学院医歯学総合研究科, プロジェクト助教 (20733900)
Project Period (FY) 2022-04-01 – 2027-03-31
Project Status Granted (Fiscal Year 2024)
Budget Amount *help
¥41,990,000 (Direct Cost: ¥32,300,000、Indirect Cost: ¥9,690,000)
Fiscal Year 2025: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2024: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2023: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2022: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Keywordsオルガノイドデザイン / ArtDo / ArtDO / 全身制御
Outline of Research at the Start

本課題では、まずオルガノイドをデザインして任意の機能を持たせることができるのかという課題に挑戦する。具体的には、腸上皮オルガノイドをアルブミン分泌細胞などの肝細胞、あるいはインスリン分泌細胞などの膵頭細胞へと誘導する方法を探索する。また、このようにデザインしたオルガノイドを大腸に移植することで、機能性臓器を異所性に作成し、肝不全モデルや糖尿病モデルで治療的な効果を発揮するか否かまでを解析し、新しい再生医療のあり方を検証する。

Outline of Annual Research Achievements

本課題は、申請者が従来取り組んできた炎症性腸疾患の難治性潰瘍を腸上皮幹細胞オルガノイドで被覆し、その完全な治癒を目指す細胞治療を推進する研究を基に、腸から樹立したオルガノイドを自在にデザインし、肝不全・糖尿病などの全身的代謝疾患の治療・予防に有効な新しいデザイン化オルガノイド『ArtDO』(Artificial Designed Organoids)を開発し、それを腸へ移植することで異所性の機能性臓器の個体内での創出を目指すArtDO構想を推進し、全身性代謝異常やホルモンネトワーク異常の是正による代謝疾患の新しい治療措置の樹立を目指す課題である。
研究2年度に当たる2023年度には、腸から樹立したオルガノイドを、肝細胞と親和性の高い吸収上皮系の細胞に誘導するさらに効率の良い方法を確立した。同時に、吸収上皮細胞から肝細胞への誘導に関して、これをブロックする腸上皮特異的な転写因子の存在も明らかにし、これの人工的な操作方法を検証した。また現在、膵内分泌ホルモンであるインスリン分泌機構に着目し、インスリン分泌を制御する責任遺伝子の同定に引き続き取り組んでいる。ArtDO-Pancreasにおいては、手術検体、EUS-FNA検体から膵GEP-NENオルガノイドを樹立し、他疾患も合わせて幅広く膵臓オルガノイドバンクを予定通
り継続して樹立している。同時にRNAの採取を行いRNAーseqを行う準備も行っている。インスリノーマ由来オルガノイドはインスリンを分泌することをより多くの症例で確認済みである。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

腸上皮細胞を肝細胞に誘導するArtDO-liverにおいても、腸上皮細胞を膵島b細胞へ誘導するArtDO-Pancreasにおいても、研究計画に記載した通りに実験が進捗しており、概ね計画通りに進行している。

Strategy for Future Research Activity

ArtDO-liverにおいては、2023年度に行なった肝細胞への成熟を阻害する、腸らしさを頑強に維持する転写因子を阻害する方法を、より効率よく進めていくとともに、細胞の機能解析をin vitroで行う。具体的には、CYP3A4アッセイ、ELISAによる培養液中のアルブミン濃度測定、蛍光標識化コレステロールを用いた脂質蓄積能の評価などを行い、デザインした肝型オルガノイドの特性を評価する。ArtDO-Pancreasにおいては、RNAシーケンスなどの手法で同定しつつある候補遺伝子群の検証について、GEP-NENオルガノイド、培養細胞を用いた機能的解析を行う予定である。

Report

(3 results)
  • 2023 Annual Research Report
  • 2022 Comments on the Screening Results   Annual Research Report
  • Research Products

    (35 results)

All 2024 2023 2022 2021

All Journal Article (20 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 20 results,  Open Access: 9 results) Presentation (15 results) (of which Int'l Joint Research: 9 results,  Invited: 4 results)

  • [Journal Article] Discovery of non-genomic drivers of YAP signaling modulating the cell plasticity in CRC tumor lines2024

    • Author(s)
      Ogasawara N, Kano Y, Yoneyama Y, Kobayashi S, Watanabe S, Kirino S, Velez-Bravo FD, Hong Y, Ostapiuk A, Lutsik P, Onishi I, Yamauchi S, Hiraguri Y, Ito G, Kinugasa Y, Ohashi K, Watanabe M, Okamoto R, Tejpar S, Yui S.
    • Journal Title

      iScience

      Volume: 27 Issue: 3 Pages: 109247-109247

    • DOI

      10.1016/j.isci.2024.109247

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Real-World Safety and Efficacy of Biosimilar CT-P13 in Patients with Immune-Mediated Inflammatory Diseaes: Integrated Analysis of Three Japanese Prospective Observational Studies.2023

    • Author(s)
      Takeuchi T, Nishikawa K, Yamada F, Morita A, Ohtsuki M, Suzuki Y, Watanabe M, Yamanaka H, HIbi T
    • Journal Title

      Drug Saf.

      Volume: 46 Issue: 10 Pages: 991-1005

    • DOI

      10.1007/s40264-023-01340-1

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apelin expression is downregulated in T cells in a murine model of chronic colitis2023

    • Author(s)
      Yamada D、Kojima Yi、Hosoya A、Suzuki、Watabe T、Inoue T、Tsugawa N、Asakawa T、Yonemoto Y、Onizawa M、Nemoto Y、Oshima S、Shimonaka M、Kuba Ki、Ishida J、Fukamizu A、Penninger JM、Watanabe M、Okamoto R、Nagaishi T
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 647 Pages: 72-79

    • DOI

      10.1016/j.bbrc.2023.01.068

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The cost of inflammatory bowel disease in high-income settings: a Lancet Gastroenterology & Hepatology Commission2023

    • Author(s)
      Burisch Johan、Zhao Mirabella、Greenberg Dan、Melberg Hans O、Watanabe Mamoru、Munkholm Pia et al.
    • Journal Title

      The Lancet Gastroenterology & Hepatology

      Volume: 8 Issue: 5 Pages: 458-492

    • DOI

      10.1016/s2468-1253(23)00003-1

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Organoids transplantation as a new modality to design epithelial signature to create a membrane-protective sulfomucin-enriched segment2023

    • Author(s)
      Watanabe Satoshi、Ogasawara Nobuhiko、Kobayashi Sakurako、Kirino Sakura、Inoue Masami、Hiraguri Yui、Nagata Sayaka、Shimizu Hiromichi、Ito Go、Mizutani Tomohiro、Nemoto Yasuhiro、Tsuchiya Kiichiro、Okamoto Ryuichi、Watanabe Mamoru、Yui Shiro
    • Journal Title

      Journal of Gastroenterology

      Volume: 58 Issue: 4 Pages: 379-393

    • DOI

      10.1007/s00535-023-01959-y

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of filgotinib as induction and maintenance therapy for Japanese patients with moderately to severely active ulcerative colitis: a post-hoc analysis of the phase 2b/3 SELECTION trial2023

    • Author(s)
      Hibi Toshifumi、Motoya Satoshi、Hisamatsu Tadakazu、Hirai Fumihito、Watanabe Kenji、Matsuoka Katsuyoshi、Saruta Masayuki、Kobayashi Taku、Feagan Brian G、Tasset Chantal、Besuyen Robin、Yun Chohee、Crans Gerald、Zhang Jie、Kondo Akira、Watanabe Mamoru
    • Journal Title

      Intestinal Research

      Volume: 21 Issue: 1 Pages: 110-125

    • DOI

      10.5217/ir.2021.00143

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Serum Leucine-Rich α2 Glycoprotein: A Novel Biomarker for Transmural Inflammation in Crohn's Disease2022

    • Author(s)
      Kento Takenaka, Yoshio Kitazume, Ami Kawamoto, Toshimitsu Fujii, Yumi Udagawa, Ryosuke Wanatabe, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Hiroyuki Sato, Akihiro Hirakawa, Mamoru Watanabe, Ryuichi Okamoto
    • Journal Title

      Am J Gastroenterol.

      Volume: - Issue: 6 Pages: 1028-1035

    • DOI

      10.14309/ajg.0000000000002127

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transmural remission characterized by high biologic concentrations demonstrates better prognosis in Crohn's disease2022

    • Author(s)
      Kento Takenaka, Ami Kawamoto, Yoshio Kitazume, Toshimitsu Fujii, Yumi Udagawa, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto
    • Journal Title

      J Crohns Colitis.

      Volume: - Issue: 6 Pages: 855-862

    • DOI

      10.1093/ecco-jcc/jjac185

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation2022

    • Author(s)
      Kobayashi S, Ogasawara N, Watanabe S, Yoneyama Y, Kirino S, Hiraguri Y, Inoue M, Nagata S, Okamoto-Uchida Y, Kofuji S, Shimizu H, Ito G, Mizutani T, Yamauchi S, Kinugasa Y, Kano Y, Nemoto Y, Watanabe M, Tsuchiya K, Nishina H, Okamoto R, Yui S.
    • Journal Title

      Inflammation and Regeneration

      Volume: 42 Issue: 1 Pages: 49-49

    • DOI

      10.1186/s41232-022-00237-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Suspension culture in a rotating bioreactor for efficient generation of human intestinal organoids2022

    • Author(s)
      Takahashi Junichi、Mizutani Tomohiro、Sugihara Hady Yuki、Nagata Sayaka、Kato Shu、Hiraguri Yui、Takeoka Sayaka、Tsuchiya Mao、Kuno Reiko、Kakinuma Sei、Watanabe Mamoru、Okamoto Ryuichi
    • Journal Title

      Cell Reports Methods

      Volume: 2 Issue: 11 Pages: 100337-100337

    • DOI

      10.1016/j.crmeth.2022.100337

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis.2022

    • Author(s)
      Tamura A, Ito G, Matsuda H, Nibe-Shirakihara Y, Hiraoka Y, Kitagawa S, Hiraguri Y, Nagata S, Aonuma E, Otsubo K, Nemoto Y, Nagaishi T, Watanabe M, Okamoto R, Oshima S.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 628 Pages: 147-154

    • DOI

      10.1016/j.bbrc.2022.08.046

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mucosal healing of small intestinal stricture is associated with improved prognosis post-dilation in Crohn's disease2022

    • Author(s)
      Shuji Hibiya, Kazuo Ohtsuka, Kento Takenaka, Ami Kawamoto, Yusuke Matsuyama, Yumi Udagawa, Maiko Motobayashi, Hiromichi Shimizu, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Ryuichi Okamoto, Mamoru Watanabe
    • Journal Title

      BMC Gastroenterol.

      Volume: 22 Issue: 1 Pages: 218-218

    • DOI

      10.1186/s12876-022-02300-2

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Higher vs Standard Adalimumab Induction and Maintenance Dosing Regimens for Treatment of Ulcerative Colitis: SERENE UC Trial Results.2022

    • Author(s)
      Panes J,Colombel JF,D’Hanes GR,Schreiber S,Panaccione R,Peyrin-Biroulet L,Loftus EV Jr,Danese S,Tanida S,Okuyama Y,Louis E,Armuzzi A,Ferrante M,Vogelsang H,Hibi T,Watanabe M,Lefebve J,Finney-Hayward T,Gonzalez YS,Doan TT,Mostafa NM,Ikeda K,Xie W,Huang B,Petersson J,Kalabic J,Robinson AM,Sandborn WJ
    • Journal Title

      Gastroenterology

      Volume: - Issue: 7 Pages: 1891-1910

    • DOI

      10.1053/j.gastro.2022.02.033

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] AJM300(carotegrast methyl), an oral antagonist of α4-integrin, as induction therapy for patients with moderately active ulcerative colitis: a multicentre, randomised, double-blind, placebo-controlled phase 3 study.2022

    • Author(s)
      Matsuoka K, Watanabe M, Ohmori T, Nakajima K, Ishida T, Ishiguro Y, Kanke K, Kobayashi K, Hirai F, Watanabe K, Mizusawa H, Kishida S, Miura Y, Ohta A, Kajioka T, Hibi T
    • Journal Title

      Lancet Gastroenterol Hepatol

      Volume: - Issue: 7 Pages: 648-657

    • DOI

      10.1016/s2468-1253(22)00022-x

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice.2022

    • Author(s)
      Hiroki Matsuda, Yoichi Nibe-Shirakihara, Akiko Tamura, Emi Aonuma, Satoko Arakawa, Kana Otsubo, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Shigeomi Shimizu, Averil Ma, Mamoru Watanabe, Motohiro Uo, Ryuichi Okamoto, Shigeru Oshima.
    • Journal Title

      Biochemical and Biophysical Research Communications.

      Volume: 592 Pages: 74-80

    • DOI

      10.1016/j.bbrc.2021.12.111

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transplantation of intestinal organoids into a mouse model of colitis2022

    • Author(s)
      Watanabe Satoshi、Kobayashi Sakurako、Ogasawara Nobuhiko、Okamoto Ryuichi、Nakamura Tetsuya、Watanabe Mamoru、Jensen Kim B.、Yui Shiro
    • Journal Title

      Nature Protocols

      Volume: 17 Issue: 3 Pages: 649-671

    • DOI

      10.1038/s41596-021-00658-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Artificial intelligence for endoscopy in inflammatory bowel disease2022

    • Author(s)
      Takenaka Kento、Kawamoto Ami、Okamoto Ryuichi、Watanabe Mamoru、Ohtsuka Kazuo
    • Journal Title

      Intestinal Research

      Volume: 20 Issue: 2 Pages: 165-170

    • DOI

      10.5217/ir.2021.00079

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study2022

    • Author(s)
      Kento Takenaka, Toshimitsu Fujii, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Chiaki Maeyashiki, Osamu Yamaji, Maiko Motobayashi, Akira Igarashi, Ryoichi Hanazawa, Shuji Hibiya, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe
    • Journal Title

      Lancet Gastroenterol Hepatol

      Volume: 7 Issue: 3 Pages: 230-237

    • DOI

      10.1016/s2468-1253(21)00372-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activated mucosal-associated invariant T cells have a pathogenic role in a murine model of inflammatory bowel disease.2022

    • Author(s)
      usuke Yasutomi, Asako Chiba, Keiichi Haga, Goh Murayama, Ayako Makiyama, Taiga Kuga, Mamoru Watanabe, Ryuichi Okamoto, Akihito Nagahara, Takashi Nagaishi, Saichiko Miyake.
    • Journal Title

      Cellular and Molecular Gastroenterology and Hepatology.

      Volume: 13 Issue: 1 Pages: 81-93

    • DOI

      10.1016/j.jcmgh.2021.08.018

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum leucine-rich α-2 glycoprotein; a novel biomarker for small bowel mucosal activity in Crohn’s Disease.2021

    • Author(s)
      Kawamoto T, Takenaka K, Hibiya S, Ohtsuka K, Okamoto R, Watanabe M
    • Journal Title

      Clin Gastroenterol Hepatol.

      Volume: 20 Issue: 5 Pages: e1196-e1200

    • DOI

      10.1016/j.cgh.2021.06.036

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Presentation] APL DOWNREGULATION IN T CELLS IN THE SETTING OF CHRONIC COLITIS.2023

    • Author(s)
      Mone Fushimi, Tadahiko Inoue, Daiki Yamada, Taro Watabe, Mamoru Watanabe, Ryuichi Okamoto, Takashi Nagaish
    • Organizer
      UEGW2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of gene expression to elucidate the pathogenesis of pancreatic solid pseudopapillary neoplasm.2023

    • Author(s)
      Hiromune Katsuda, Go Ito, Yui Hiraguri, Tomohiro Muto, Shun Ishido, Masanori Kobayashi, Hironari Yamashita, Akira Ito, Hiroaki Ono, Atsushi Kudo, Mamoru Watanabe, Minoru Tanabe, Ryuichi Okamoto
    • Organizer
      UEGW2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fetal-like reprogramming is the key to understand the heterogeneity of colorectal cancer.2023

    • Author(s)
      Shiro Yui
    • Organizer
      The 41st Sapporo International Cancer Symposium
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ECM-niche dependent plasticity controls the acquisition of invasive phenotype in colorectal cancer2023

    • Author(s)
      Nobuhiko Ogasawara, Yoshihito Kano, Sakurako Kobayashi, Satoshi Watanabe, Sakura Kirino, Iichiroh Onishi, Shinichi Yamauchi, Yui Hiraguri, Go Ito, Mamoru Watanabe, Yusuke Kinugasa, Kenichi Ohashi, Ryuichi Okamoto, Shiro Yui
    • Organizer
      第82回日本癌学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Delineation of the role of the Autophagy protein Atg16L1 for epithelial proliferation and cell death via type1 interferon2023

    • Author(s)
      Go Ito, Mishra N, Rosenstiel P, Mamoru Watanabe
    • Organizer
      GI research academy
    • Related Report
      2023 Annual Research Report
  • [Presentation] Unveiling the gene network behind cell plasticity provides a novel insight into the therapeutic approach for human colorectal cancer.2023

    • Author(s)
      Nobuhiko Ogasawara, Yoshihito Kano, Sakurako Kobayashi, Satoshi Watanabe, Sakura Kirino, Iichiroh Onishi, Shinichi Yamauchi, Yui Hiraguri, Go Ito, Mamoru Watanabe, Yusuke Kinugasa, Kenichi Ohashi, Ryuichi Okamoto, Shiro Yui
    • Organizer
      Keystone Symposia, The resident tumor microenvironment
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 半世紀を迎えた難病研究班の現在、過去、未来2022

    • Author(s)
      渡辺 守
    • Organizer
      第13回日本炎症性腸疾患学会学術集会(特別企画1)
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 難病医療ネットワークのこれまでと今後 ~レジェンドからのメッセージ~ 消化器難病関連の難病医療ネットワークのこれまでと今後2022

    • Author(s)
      渡辺 守
    • Organizer
      日本難病医療ネットワーク学会シンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 小腸からヒト全身を繙く時代へ2022

    • Author(s)
      渡辺 守
    • Organizer
      第60回日本小腸学会学術集会(特別講演)
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Association of Ulcerative Colitis Bowel Urgency Improvement With Clinical Response and Remission.2022

    • Author(s)
      David B. Clemow, Christophe Sapin, Toshifumi Hibi, Marla C. Dubinsky, Severine Vermeire, Stefan Schreiber, Theresa Hunter Gibble, Laurent Peyrin-Biroulet, Mamoru Watanabe, Remo Panaccione
    • Organizer
      UEGW2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of molecular characteristics and metastatic mechanism of pancreatic neuroendocrine neoplasms2022

    • Author(s)
      Go Ito, Konrad Aden, Philip Rosenstiel, Mamoru Watanabe et al.
    • Organizer
      International Syscid Symposium 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Application of DSS-Grafting Assay to Evaluate the Potential of Cecum Organoids as a Useful Cellular Source for the Treatment of Colitis2022

    • Author(s)
      Satoshi Watanabe, Nobuhiko Ogasawara, Sakurako Kobayashi , Go Ito, Yoshihito Kano, Tomohiro Mizutani, Hiromichi Shimizu , Mamoru Watanabe, Ryuichi Okamoto, Shiro Yui
    • Organizer
      DDW2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dissection of inflammatory and regenerative signature of intestinal epithelium via in vitro culture recapitulating the repair process2022

    • Author(s)
      Sakurako Kobayashi, Nobuhiko Ogasawara, Satoshi Watanabe, Go Ito, Yoshihito Kano, Tomohiro Mizutani, Hiromichi Shimizu , Mamoru Watanabe, Ryuichi Okamoto, Shiro Yui
    • Organizer
      DDW2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dissection of cancer cell plasticity in a novel defined culture system for human colorectal cancer2022

    • Author(s)
      Nobuhiko Ogasawara, Sakurako Kobayashi, Satoshi Watanabe, Go Ito, Yoshihito Kano, Tomohiro Mizutani, Hiromichi Shimizu , Mamoru Watanabe, Ryuichi Okamoto, Shiro Yui
    • Organizer
      DDW2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 日本発の経口インテグリン阻害薬がもたらす潰瘍性大腸炎治療の新たな選択肢2022

    • Author(s)
      渡辺 守
    • Organizer
      第103回日本消化器内視鏡学会総会セミナー
    • Related Report
      2022 Annual Research Report
    • Invited

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Published: 2022-04-19   Modified: 2025-04-17  

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