Reconsideration of the diagnostic system for neurodevelopmental disorders with a focus on functional impairment

• Project/Area Number: 22H00492
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 58:Society medicine, nursing, and related fields
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: 土屋 賢治 浜松医科大学, 子どものこころの発達研究センター, 特任教授 (20362189)
• Co-Investigator(Kenkyū-buntansha): 友田 明美 福井大学, 子どものこころの発達研究センター, 教授 (80244135) ; 伊東 宏晃 浜松医科大学, 医学部, 教授 (70263085) ; 原 武史 岐阜大学, 工学部, 教授 (10283285) ; 松崎 秀夫 福井大学, 子どものこころの発達研究センター, 教授 (00334970) ; 高橋 長秀 名古屋大学, 医学部附属病院, 准教授 (50846714) ; 大島 郁葉 千葉大学, 子どものこころの発達教育研究センター, 教授 (40625472) ; 西村 倫子 浜松医科大学, 子どものこころの発達研究センター, 特任講師 (30773791) ; 戸田 重誠 昭和大学, 医学部, 准教授 (00323006)
• Project Period (FY): 2022-04-01 – 2025-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000); Fiscal Year 2024: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000); Fiscal Year 2023: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000); Fiscal Year 2022: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
• Keywords: 発達障がい / 機能障害 / 自閉スペクトラム症 / 注意欠如多動症 / 機能障がい / 出生コホート / 神経発達症 / 診断

Outline of Research at the Start

神経発達症の診断体系は，それに伴って日常生活に生ずる支障や困難（機能障がい）を正しく反映しない。そこで本課題は，あたらしい「機能障がい指標」を開発し，神経発達症の臨床にいかす道筋を作る。具体的には，①疾病，個人要因，環境要因，心身機能，活動，参加の定量的計測から機能障がいの強さと支援の必要性を段階的に反映する「機能障がい指標」を作成し，②機能障がい指標の神経生理，遺伝，認知の3領域における生物学的基盤を検索し，生物医学的機能障がい指標の開発をめざす。ついで，③機能障がいの評価が当事者にもたらす心理学的影響を検討し，臨床的意義と倫理性を検討する（2022～24年度，3年間の予定）。

Outline of Annual Research Achievements

本研究の目的は、神経発達症に伴う機能障害の生物学的および社会心理学的基盤を探索し、神経発達症の診断体系を再構成することである。浜松母と子の出生コホート研究は、6歳における注視パターンが8～9歳における社会機能と関連すること、すなわち、デジタルバイオマーカーが生物学的機能障がい指標となりうることを明らかにした（Mori et al, Front Psychiatry 2023）。また、幼少期のデジタル曝露は、幼児期における機能障害の危険因子となりうるが、その曝露自体は神経発達症の遺伝学的リスクによって説明されることをあきらかにした（Takahashi et al, JAMA Pediatr 2023）。被虐待経験が脳にもたらす影響に関する研究を総括し、まとめた（Tomoda et al, Euro Arch Psych Clin Neuro 2024）。昨年度明らかになった臍帯血中のエポキシ脂肪酸濃度と神経発達症の関連を示す知見を発展させ、知財化および社会実装の検討に入った。倫理面および社会実装に関する検討においては、神経発達症、とくに自閉スペクトラム症をもつ人々の「カムフラージング」について実態調査を進め、ゆきすぎたカムフラージングもしくは過小なカムフラージングが自閉スペクトラム症者のメンタルヘルスに負荷を与えることを明らかにした（Oshima et al, Mol Autism 2024）。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

本研究は多角的な視点から神経発達症の理解を深めるための重要なステップを踏んでいる。特に、デジタルバイオマーカーの可能性を示すことは、神経発達症の診断体系の再構成に対する有意義な貢献である。また、知見の知財化および社会実装の検討に入ったことは、研究成果の実用化に向けた重要な進展である。一方、研究成果の発表は昨年度の水準には達していない。全体として、期待を超えた水準ではないものの、計画どおりの進捗を通して神経発達症の理解を深めための重要な進歩を遂げているといえる。

Strategy for Future Research Activity

最終年度は，これまでに見出された「機能障がい予測指標」を用いて，機械学習の知見を駆使した「機能障がい予測モデル」を確立する。これをもって，神経発達症の新しい理解を深めるとともに，介入の方向性についての重要な示唆を得ることを目指す。

Research Products

• [Int'l Joint Research] ニューヨーク市立大/マウントサイナイ大学(米国)
• [Int'l Joint Research] ニューヨーク市立大/マウントサイナイ大学(米国)
• [Journal Article] The Population-Attributable Fractions of Small-for-Gestational-Age Births: Results from the Japan Birth Cohort Consortium (2024)
  • Author(s): Ishitsuka K, Piedvache A, Kobayashi S, Iwama N, Nishimura T, Watanabe M, Metoki H, Iwata H, Miyashita C, Ishikuro M, Obara T, Sakurai K, Rahman MS, Tanaka K, Miyake Y, Horikawa R, Kishi R, Tsuchiya KJ, Mori C, Kuriyama S, Morisaki N
  • Journal Title: Nutrients Volume: 16 Issue: 2 Pages: 186-186
  • DOI: 10.3390/nu16020186
  • Peer Reviewed / Open Access
• [Journal Article] Association between infertility treatment and hypertensive disorders of pregnancy in the Japan Birth Cohort Consortium: a meta-analysis (2024)
  • Author(s): Ishikuro Mami、Nishimura Tomoko、Iwata Hiroyoshi、Metoki Hirohito、Obara Taku、Iwama Noriyuki、Murakami Keiko、Rahman Md. Shafiur、Tojo Maki、Kobayashi Sumitaka、Miyashita Chihiro、Tanaka Keiko、Miyake Yoshihiro、Ishitsuka Kazue、Horikawa Reiko、Morisaki Naho、Yamamoto Midori、Sakurai Kenichi、Mori Chisato、他5名
  • Journal Title: Journal of Human Hypertension Volume: 38 Issue: 2 Pages: 187-190
  • DOI: 10.1038/s41371-023-00890-2
  • Peer Reviewed / Open Access
• [Journal Article] Diffusion tensor imaging of white-matter structural features of maltreating mothers and their associations with intergenerational chain of childhood abuse (2024)
  • Author(s): Kurata Sawa、Nishitani Shota、Kawata Natasha Y. S.、Yao Akiko、Fujisawa Takashi X.、Okazawa Hidehiko、Tomoda Akemi
  • Journal Title: Scientific Reports Volume: 14 Issue: 1 Pages: 5671-5671
  • DOI: 10.1038/s41598-024-53666-0
  • Peer Reviewed / Open Access
• [Journal Article] The neurobiological effects of childhood maltreatment on brain structure, function, and attachment (2024)
  • Author(s): Tomoda Akemi、Nishitani Shota、Takiguchi Shinichiro、Fujisawa Takashi X.、Sugiyama Toshiro、Teicher Martin H.
  • Journal Title: European Archives of Psychiatry and Clinical Neuroscience Volume: NA
  • DOI: 10.1007/s00406-024-01779-y
  • Peer Reviewed / Open Access
• [Journal Article] Data science using the human epigenome for predicting multifactorial diseases and symptoms (2024)
  • Author(s): Nishitani Shota、Smith Alicia K、Tomoda Akemi、Fujisawa Takashi X
  • Journal Title: Epigenomics Volume: 16 Issue: 5 Pages: 273-276
  • DOI: 10.2217/epi-2023-0321
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparative analysis of hyperfibrinolysis with activated coagulation between amniotic fluid embolism and severe placental abruption (2024)
  • Author(s): Ide Rui、Oda Tomoaki、Todo Yusuke、Kawai Kenta、Matsumoto Masako、Narumi Megumi、Kohmura-Kobayashi Yukiko、Furuta-Isomura Naomi、Yaguchi Chizuko、Uchida Toshiyuki、Suzuki Kazunao、Kanayama Naohiro、Itoh Hiroaki、Tamura Naoaki
  • Journal Title: Scientific Reports Volume: 14 Issue: 1 Pages: 272-272
  • DOI: 10.1038/s41598-023-50911-w
  • Peer Reviewed / Open Access
• [Journal Article] A Case of Consumptive Coagulopathy Before Cardiopulmonary Failure in Amniotic Fluid Embolism and Review of Literature: A Perspective of the Latent Onset and Progression of Coagulopathy (2024)
  • Author(s): Oda Tomoaki、Tamura Naoaki、Yata Daisuke、Oda-Kishimoto Ayako、Itoh Toshiya、Kubota Naohiro、Suzuki Yasuyuki、Kanayama Naohiro、Itoh Hiroaki
  • Journal Title: Cureus Volume: 16 Pages: 55961-55961
  • DOI: 10.7759/cureus.55961
  • Peer Reviewed / Open Access
• [Journal Article] Investigation of optimal weight gain during pregnancy: A retrospective analysis of the Japanese perinatal registry database (2024)
  • Author(s): Takeda Jun、Morisaki Naho、Itakura Atsuo、Aoki Shigeru、Sago Haruhiko、Nagamatsu Takeshi、Masuyama Hisashi、Matsubara Shigeki、Umazume Takeshi、Mitsuda Nobuaki、Itoh Hiroaki、Ikeda Tomoaki、Perinatal Committee of the Japanese Society of Obstetrics and Gynecology
  • Journal Title: Journal of Obstetrics and Gynaecology Research Volume: 50 Issue: 3 Pages: 403-423
  • DOI: 10.1111/jog.15863
  • Peer Reviewed
• [Journal Article] Eurycomanone from <i>Eurycoma longifolia</i> Jack upregulates neurotrophin-3 gene expression in ‍retinal Müller cells <i>in vitro</i> (2024)
  • Author(s): Sakai Yumi、Yamada Masayoshi、Watanabe Tomomichi、Yamazaki Arisa、Furukawa Megumi、Izumo Nobuo、Matsuzaki Hideo
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 74 Issue: 3 Pages: 199-206
  • DOI: 10.3164/jcbn.23-73
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Pulmonary Tumor Thrombotic Microangiopathy Caused by Metastatic Ovarian Cancer: An Antemortem Diagnosis with Pulmonary Aspiration Cytopathology (2023)
  • Author(s): Unno K, Ohtani H, Sakamoto A, Murakami H, Yagi H, Ito H, Baba S, Iwashita T, Kosugi I, Maekawa Y
  • Journal Title: Internal Medicine Volume: 62 Issue: 24 Pages: 3649-3655
  • DOI: 10.2169/internalmedicine.1641-23
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2023-12-15
  • Peer Reviewed / Open Access
• [Journal Article] Autism symptoms, functional impairments, and gaze fixation measured using an eye-tracker in 6-year-old children (2023)
  • Author(s): Mori Toko、Tsuchiya Kenji J.、Harada Taeko、Nakayasu Chikako、Okumura Akemi、Nishimura Tomoko、Katayama Taiichi、Endo Masayuki
  • Journal Title: Frontiers in Psychiatry Volume: 14 Pages: 1250763-1250763
  • DOI: 10.3389/fpsyt.2023.1250763
  • Peer Reviewed / Open Access
• [Journal Article] The association between screen time and genetic risks for neurodevelopmental disorders in children (2023)
  • Author(s): Takahashi Nagahide、Tsuchiya Kenji J.、Okumura Akemi、Harada Taeko、Iwabuchi Toshiki、Rahman Md Shafiur、Kuwabara Hitoshi、Nomura Yoko、Nishimura Tomoko
  • Journal Title: Psychiatry Research Volume: 327 Pages: 115395-115395
  • DOI: 10.1016/j.psychres.2023.115395
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Screen Time at Age 1 Year and Communication and Problem-Solving Developmental Delay at 2 and 4 Years (2023)
  • Author(s): Takahashi I, Obara T, Ishikuro M, Murakami K, Ueno F, Noda A, Onuma T, Shinoda G, Nishimura T, Tsuchiya KJ, Kuriyama S
  • Journal Title: JAMA Pediatrics Volume: 177 Issue: 10 Pages: 1039-1046
  • DOI: 10.1001/jamapediatrics.2023.3057
  • Peer Reviewed / Open Access
• [Journal Article] Study Inclusions in the Association Between Screen Time and Neurodevelopment in Early Childhood?Reply (2023)
  • Author(s): Tsuchiya Kenji J.、Okubo Yusuke、Nishimura Tomoko
  • Journal Title: JAMA Pediatrics Volume: 177 Issue: 7 Pages: 739-739
  • DOI: 10.1001/jamapediatrics.2023.1188
  • Peer Reviewed / Open Access
• [Journal Article] Interaction of genetic liability for attention deficit hyperactivity disorder (ADHD) and perinatal inflammation contributes to ADHD symptoms in children (2023)
  • Author(s): Takahashi Nagahide、Nishimura Tomoko、Harada Taeko、Okumura Akemi、Iwabuchi Toshiki、Rahman Md Shafiur、Kuwabara Hitoshi、Takagai Shu、Usui Noriyoshi、Makinodan Manabu、Matsuzaki Hideo、Ozaki Norio、Itoh Hiroaki、Nomura Yoko、Newcorn Jeffrey H.、Tsuchiya Kenji J.
  • Journal Title: Brain, Behavior, &amp; Immunity - Health Volume: 30 Pages: 100630-100630
  • DOI: 10.1016/j.bbih.2023.100630
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Child Developmental MRI (CDM) project: protocol for a multi-centre, cross-sectional study on elucidating the pathophysiology of attention-deficit/hyperactivity disorder and autism spectrum disorder through a multi-dimensional approach (2023)
  • Author(s): Yamashita, M., Kagitani-Shimono, K., Hirano, Y., Hamatani, S., Nishitani, S., Yao, A., Kurata, S., Kosaka, H., Jung, M., Yoshida, T., Sasaki, T., Matsumoto, K., Kato, Y., Nakanishi, M., Tachibana, M., Mohri, I., Tsuchiya, K. J., Tsujikawa, T., Okazawa, H., Shimizu, E., … Mizuno, Y.
  • Journal Title: BMJ Open Volume: 13 Issue: 6 Pages: e070157-e070157
  • DOI: 10.1136/bmjopen-2022-070157
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Socioeconomic and education-based inequality in suspected developmental delays among Nepalese children: a subnational level assessment (2023)
  • Author(s): Acharya Kiran, Rahman Md. Shafiur, Islam Md. Rashedul, Gilmour Stuart, Dhungel Bibha, Parajuli Rajendra P, Nishimura Tomoko, Senju Atsushi, Tsuchiya Kenji J.
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 4750-4750
  • DOI: 10.1038/s41598-023-31629-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Determinants and Projections of Minimum Acceptable Diet among Children Aged 6?23 Months: A National and Subnational Inequality Assessment in Bangladesh (2023)
  • Author(s): Rahman Md. Shafiur、Chowdhury Md. Rocky Khan、Islam Md. Rashedul、Krull Abe Sarah、Hossain Kamal、Iwabuchi Toshiki、Tsuchiya Kenji J.、Gilmour Stuart
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 20 Issue: 3 Pages: 2010-2010
  • DOI: 10.3390/ijerph20032010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 子どものスクリーンタイム・神経発達・外遊び (2023)
  • Author(s): 土屋賢治
  • Journal Title: 医学のあゆみ Volume: 287 Pages: 285-286
• [Journal Article] Neural and behavioral effects of parent training on emotion recognition in mothers rearing children with attention-deficit/hyperactivity disorder (2023)
  • Author(s): Makita Kai、Yao Akiko、Shimada Koji、Kasaba Ryoko、Fujisawa Takashi X.、Mizuno Yoshifumi、Tomoda Akemi
  • Journal Title: Brain Imaging and Behavior Volume: - Issue: 4 Pages: 436-449
  • DOI: 10.1007/s11682-023-00771-9
  • Peer Reviewed / Open Access
• [Journal Article] Triadic Therapy Based on Somatic Eye Movement Desensitization and Reprocessing for Complex Posttraumatic Stress Disorder: A Pilot Randomized Controlled Study (2023)
  • Author(s): Wakusawa Keisuke、Sugiyama Toshiro、Hotta Hiroshi、Wada Kohei、Suzuki Futoshi、Morimoto Takeshi、Shiino Tomoko、Tomoda Akemi
  • Journal Title: Journal of EMDR Practice and Research Volume: 17 Issue: 3 Pages: 159-170
  • DOI: 10.1891/emdr-2023-0014
  • Peer Reviewed / Open Access
• [Journal Article] Bayesian dynamical system analysis of the effects of methylphenidate in children with attention-deficit/hyperactivity disorder: a randomized trial (2023)
  • Author(s): Cai Weidong、Mizuno Yoshifumi、Tomoda Akemi、Menon Vinod
  • Journal Title: Neuropsychopharmacology Volume: 48 Issue: 11 Pages: 1690-1698
  • DOI: 10.1038/s41386-023-01668-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of the pooled sample method in Infinium MethylationEPIC BeadChip array by comparison with individual samples (2023)
  • Author(s): Nishitani Shota、Fujisawa Takashi X.、Yao Akiko、Takiguchi Shinichiro、Tomoda Akemi
  • Journal Title: Clinical Epigenetics Volume: 15 Issue: 1 Pages: 138-138
  • DOI: 10.1186/s13148-023-01544-3
  • Peer Reviewed
• [Journal Article] Longitudinal changes in attention bias to infant crying in primiparous mothers (2023)
  • Author(s): Hiraoka Daiki、Makita Kai、Sakakibara Nobuko、Morioka Shigemi、Orisaka Makoto、Yoshida Yoshio、Tomoda Akemi
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 17 Pages: 1192275-1192275
  • DOI: 10.3389/fnbeh.2023.1192275
  • Peer Reviewed / Open Access
• [Journal Article] Identifying Active Progeny Virus Particles in Formalin-Fixed, Paraffin-Embedded Sections Using Correlative Light and Scanning Electron Microscopy (2023)
  • Author(s): Itoh Toshiya、Yamada Satoshi、Ohta Isao、Meguro Shiori、Kosugi Isao、Iwashita Toshihide、Itoh Hiroaki、Kanayama Naohiro、Okudela Koji、Sugimura Haruhiko、Misawa Kiyoshi、Hariyama Takahiko、Kawasaki Hideya
  • Journal Title: Laboratory Investigation Volume: 103 Issue: 1 Pages: 100020-100020
  • DOI: 10.1016/j.labinv.2022.100020
  • Peer Reviewed / Open Access
• [Journal Article] Uterotonic administration during cesarean section in Japan (2023)
  • Author(s): Naruse Satoshi、Mazda Yusuke、Akinaga Chieko、Itoh Hiroaki、Nakajima Yoshiki
  • Journal Title: Journal of Anesthesia Volume: 4 Issue: 4 Pages: 4-4
  • DOI: 10.1007/s00540-023-03194-4
  • Peer Reviewed
• [Journal Article] Massive platelet‐rich thrombus formation in small pulmonary vessels in amniotic fluid embolism: An autopsy study (2023)
  • Author(s): Yamashita Atsushi、Oda Tomoaki、Aman Murasaki、Wakasa Tomoko、Gi Toshihiro、Ide Rui、Todo Yusuke、Tamura Naoaki、Sato Yuichiro、Itoh Hiroaki、Asada Yujiro
  • Journal Title: BJOG: An International Journal of Obstetrics &amp; Gynaecology Volume: 130 Issue: 13 Pages: 1685-1696
  • DOI: 10.1111/1471-0528.17532
  • Peer Reviewed / Open Access
• [Journal Article] Outdoor Play as a Mitigating Factor in the Association Between Screen Time for Young Children and Neurodevelopmental Outcomes (2023)
  • Author(s): Sugiyama Mika、Tsuchiya Kenji J.、Okubo Yusuke、Rahman Mohammad Shafiur、Uchiyama Satoshi、Harada Taeko、Iwabuchi Toshiki、Okumura Akemi、Nakayasu Chikako、Amma Yuko、Suzuki Haruka、Takahashi Nagahide、Kinsella-Kammerer Barbara、Nomura Yoko、Itoh Hiroaki、Nishimura Tomoko
  • Journal Title: JAMA Pediatrics Volume: 177 Issue: 3 Pages: 303-303
  • DOI: 10.1001/jamapediatrics.2022.5356
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of stable environments on maltreated children (2023)
  • Author(s): Koizumi Michiko、Tomoda Akemi、Takiguchi Shinichiro、Kosaka Hirotaka
  • Journal Title: Pediatrics International Volume: 65 Issue: 1
  • DOI: 10.1111/ped.15443
  • Peer Reviewed / Open Access
• [Journal Article] Effects of intranasal oxytocin on neural reward processing in children and adolescents with reactive attachment disorder: A randomized controlled trial (2023)
  • Author(s): Takiguchi Shinichiro、Makita Kai、Fujisawa Takashi X.、Nishitani Shota、Tomoda Akemi
  • Journal Title: Frontiers in Child and Adolescent Psychiatry Volume: 1 Pages: 1-16
  • DOI: 10.3389/frcha.2022.1056115
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of prenatal cannabis exposure on developmental trajectory of cognitive ability and brain volumes in the adolescent brain cognitive development (ABCD) study (2023)
  • Author(s): Hiraoka Daiki、Makita Kai、Hamatani Sayo、Tomoda Akemi、Mizuno Yoshifumi
  • Journal Title: Developmental Cognitive Neuroscience Volume: 60 Pages: 101209-101209
  • DOI: 10.1016/j.dcn.2023.101209
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cross-tissue correlations of genome-wide DNA methylation in Japanese live human brain and blood, saliva, and buccal epithelial tissues. (2023)
  • Author(s): Nishitani S, Isozaki M, Yao A, Higashino Y, Yamauchi T, Kidoguchi M, Kawajiri S, Tsunetoshi K, Neish H, Imoto H, Arishima H, Kodera T, Fujisawa TX, Nomura S, Kikuta K, Shinozaki G, Tomoda A.
  • Journal Title: Transl Psychiatry Volume: 13 Issue: 1 Pages: 72-72
  • DOI: 10.1038/s41398-023-02370-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pregnancy complicated by neurofibromatosis type 1 in a patient with a history of massive spontaneous hemothorax: a case report (2022)
  • Author(s): Kitamoto Mei、Narumi Megumi、Oda Tomoaki、Tamura Naoaki、Uchida Toshiyuki、Itoh Hiroaki
  • Journal Title: Hypertension Research in Pregnancy Volume: 10 Issue: 4 Pages: 121-124
  • DOI: 10.14390/jsshp.HRP2022-006
  • ISSN: 2187-5987, 2187-9931
  • Year and Date: 2022-11-30
  • Peer Reviewed / Open Access
• [Journal Article] Does Treatment Stigma among Adolescents with Autistic Spectrum Disorder and Their Guardians Affect the Effectiveness of Cognitive Behavioral Therapy? A Secondary Analysis of a Randomized Controlled Trial (2022)
  • Author(s): Emiko Oshita , Fumiyo Oshima , Minako Hongo , Siqing Guan , Yusuke Nitta , Eiji Shimizu
  • Journal Title: 子どものこころと脳の発達 Volume: 15 Issue: 1 Pages: 1-1
  • DOI: 10.1186/s13229-023-00579-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neural mechanisms underlying rule selection based on response evaluation: a near-infrared spectroscopy study (2022)
  • Author(s): Harada Taeko、Iwabuchi Toshiki、Senju Atsushi、Nakayasu Chikako、Nakahara Ryuji、Tsuchiya Kenji J、Hoshi Yoko
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 20696-20696
  • DOI: 10.1038/s41598-022-25185-3
  • Peer Reviewed / Open Access
• [Journal Article] Early temperament as a predictor of language skills at 40th months (2022)
  • Author(s): Ishikawa-Omori Yuuka、Nishimura Tomoko、Nakagawa Atsuko、Okumura Akemi、Harada Taeko、Nakayasu Chikako、Iwabuchi Toshiki、Amma Yuko、Suzuki Haruka、Rahman Mohammad Shafiur、Nakahara Ryuji、Takahashi Nagahide、Nomura Yoko、Tsuchiya Kenji J.
  • Journal Title: BMC Pediatrics Volume: 22 Issue: 1 Pages: 56-56
  • DOI: 10.1186/s12887-022-03116-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of neurodevelopmental transition patterns from infancy to early childhood and risk factors predicting descending transition (2022)
  • Author(s): Kato Takeo、Nishimura Tomoko、Takahashi Nagahide、Harada Taeko、Okumura Akemi、Iwabuchi Toshiki、Nomura Yoko、Senju Atsushi、Tsuchiya Kenji J.、Takei Nori
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 4822-4822
  • DOI: 10.1038/s41598-022-08827-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Trajectories of Adaptive Behaviors During Childhood in Females and Males in the General Population (2022)
  • Author(s): Nishimura Tomoko、Kato Takeo、Okumura Akemi、Harada Taeko、Iwabuchi Toshiki、Rahman Md. Shafiur、Hirota Tomoya、Takahashi Michio、Adachi Masaki、Kuwabara Hitoshi、Takagai Shu、Nomura Yoko、Takahashi Nagahide、Senju Atsushi、Tsuchiya Kenji J.
  • Journal Title: Frontiers in Psychiatry Volume: 13 Pages: 817383-817383
  • DOI: 10.3389/fpsyt.2022.817383
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Placental pathology predicts infantile neurodevelopment (2022)
  • Author(s): Ueda Megumi、Tsuchiya Kenji J.、Yaguchi Chizuko、Furuta-Isomura Naomi、Horikoshi Yoshimasa、Matsumoto Masako、Suzuki Misako、Oda Tomoaki、Kawai Kenta、Itoh Toshiya、Matsuya Madoka、Narumi Megumi、Kohmura-Kobayashi Yukiko、Tamura Naoaki、Uchida Toshiyuki、Itoh Hiroaki
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 2578-2578
  • DOI: 10.1038/s41598-022-06300-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Linoleic acid and linoleate diols in neonatal cord blood influence birth weight (2022)
  • Author(s): Umeda N, Hirai T, Ohto-Nakanishi T, Tsuchiya KJ, Matsuzaki H
  • Journal Title: Frontiers in Endocrinology Volume: 13
  • DOI: 10.3389/fendo.2022.986650
  • Peer Reviewed / Open Access
• [Journal Article] Maternal Plasma and Cord Blood Concentration Profiles of Duloxetine During the Peripartum Period and Their Associations With the Modified Finnegan Score (2022)
  • Author(s): Taguchi Reina、Naito Takafumi、Suzuki Koji、Kurosawa Yuko、Itoh Hiroaki、Kawakami Junichi
  • Journal Title: Therapeutic Drug Monitoring Volume: 44 Issue: 2 Pages: 351-352
  • DOI: 10.1097/ftd.0000000000000943
  • Peer Reviewed
• [Journal Article] Comparative Analysis of Gene Expression Profiles in the Adipose Tissue of Obese Adult Mice With Rapid Infantile Growth After Undernourishment In Utero (2022)
  • Author(s): Suzuki Misako、Kohmura-Kobayashi Yukiko、Ueda Megumi、Furuta-Isomura Naomi、Matsumoto Masako、Oda Tomoaki、Kawai Kenta、Itoh Toshiya、Matsuya Madoka、Narumi Megumi、Tamura Naoaki、Uchida Toshiyuki、Mochizuki Kazuki、Itoh Hiroaki
  • Journal Title: Frontiers in Endocrinology Volume: 13 Pages: 818064-818064
  • DOI: 10.3389/fendo.2022.818064
  • Peer Reviewed / Open Access
• [Journal Article] Intrauterine hyponutrition reduces fetal testosterone production and postnatal sperm count in the mouse. (2022)
  • Author(s): Fujisawa Y, Ono H, Konno A, Yao I, Itoh H, Baba T, Morohashi K, Katoh-Fukui Y, Miyado M, Fukami M and Ogata T.
  • Journal Title: Journal of the Endocrine Society Volume: 6 Issue: 4 Pages: 1-11
  • DOI: 10.1210/jendso/bvac022
  • Peer Reviewed / Open Access
• [Journal Article] Developmental Origins of Metaflammation; A Bridge to the Future Between the DOHaD Theory and Evolutionary Biology (2022)
  • Author(s): Itoh Hiroaki、Ueda Megumi、Suzuki Misako、Kohmura-Kobayashi Yukiko
  • Journal Title: Frontiers in Endocrinology Volume: 13 Pages: 839436-839436
  • DOI: 10.3389/fendo.2022.839436
  • Peer Reviewed / Open Access
• [Journal Article] Editorial: A Half-Century History of Nutritional Guidance for Pregnant Women in Japan: A Promising Research Target of the DOHaD Study (2022)
  • Author(s): Itoh Hiroaki、Aoyama Tomoko、Kohmura-Kobayashi Yukiko、Nemoto Takahiro
  • Journal Title: Frontiers in Endocrinology Volume: 13 Pages: 942256-942256
  • DOI: 10.3389/fendo.2022.942256
  • Peer Reviewed / Open Access
• [Journal Article] The effectiveness and cost-effectiveness of Well Parent Japan for Japanese mothers of children with ADHD: Protocol for a randomized controlled trial (2022)
  • Author(s): Shizuka Shimabukuro, David Daley, Takahiro Endo, Satoshi Harada, Akemi Tomoda, Yushiro Yamashita, Takashi Oshio, et al.
  • Journal Title: JMIR Research Protocols Volume: 11 Issue: 4 Pages: e32693-e32693
  • DOI: 10.2196/32693
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Beneficial Effects of Behavioral Parent Training on Inhibitory Control in Children With Attention-Deficit/Hyperactivity Disorder: A Small-Scale Randomized Controlled Trial (2022)
  • Author(s): Yao Akiko、Shimada Koji、Kasaba Ryoko、Tomoda Akemi
  • Journal Title: Frontiers in Psychiatry Volume: 13 Pages: 1-10
  • DOI: 10.3389/fpsyt.2022.859249
  • Peer Reviewed / Open Access
• [Journal Article] The influence of intelligence and cognitive abilities on the reading ability of Japanese students with developmental disorders (2022)
  • Author(s): Yamaguchi Daisuke、Hiratani Michio、Matsuura Naomi、Fujisawa Takashi X.、Takiguchi Shinichiro、Fujioka Toru、Kono Toshihiro、Ishizaka Ikuyo、Tomoda Akemi
  • Journal Title: Brain and Development Volume: 44 Issue: 6 Pages: 361-371
  • DOI: 10.1016/j.braindev.2022.02.006
  • Peer Reviewed / Open Access
• [Journal Article] Guided internet-based cognitive behavioral therapy for obsessive-compulsive disorder: A multicenter randomized controlled trial in Japan (2022)
  • Author(s): Matsumoto Kazuki、Hamatani Sayo、Makino Takuya、Takahashi Jumpei、Suzuki Futoshi、Ida Tomoko、Hamamura Shoko、Takiguchi Shinichiro、Tomoda Akemi、Omori Ichiro M.、Kosaka Hirotaka、Shinno Seina、Ikai Tomoki、Hayashi Hiroyuki、Katayama Hiroto、Shiko Yuki、Ozawa Yoshihito、Kawasaki Yohei、Sutoh Chihiro、Shimizu Eiji
  • Journal Title: Internet Interventions Volume: 28 Pages: 100515-100515
  • DOI: 10.1016/j.invent.2022.100515
  • Peer Reviewed / Open Access
• [Journal Article] Methylphenidate remediates aberrant brain network dynamics in children with attention‐deficit/hyperactivity disorder: A randomized controlled trial (2022)
  • Author(s): Mizuno Yoshifumi、Cai Weidong、Supekar Kaustubh、Makita Kai、Takiguchi Shinichiro、Tomoda Akemi、Menon Vinod
  • Journal Title: NeuroImage Volume: 257 Pages: 119332-119332
  • DOI: 10.1016/j.neuroimage.2022.119332
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Longitudinal impact of COVID-19 pandemic on mental health of children in the ABCD study cohort (2022)
  • Author(s): Hamatani Sayo、Hiraoka Daiki、Makita Kai、Tomoda Akemi、Mizuno Yoshifumi
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 19601-19601
  • DOI: 10.1038/s41598-022-22694-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phldb2 is essential for regulating hippocampal dendritic spine morphology through drebrin in an adult-type isoform-specific manner. (2022)
  • Author(s): Xie MJ, Yagi H, Iguchi T, Yamazaki H, Hanamura K, Matsuzaki H, Shirao T, Sato M.
  • Journal Title: Neurosci. Res. Volume: 185 Pages: 1-1
  • DOI: 10.1016/j.neures.2022.09.010
  • Peer Reviewed
• [Journal Article] Asymmetric Complexity in a Pupil Control Model With Laterally Imbalanced Neural Activity in the Locus Coeruleus: A Potential Biomarker for Attention-Deficit/Hyperactivity Disorder (2022)
  • Author(s): Hiraku Kumano, Sou Nobukawa, Aya Shirama, Tetsuya Takahashi, Toshinobu Takeda, Ohta Haruhisa, Mitsuru Kikuchi, Akira Iwanami, Nobumasa Kato, Shigenobu Toda
  • Journal Title: Neural Computation Volume: 34 Issue: 12 Pages: 2388-2407
  • DOI: 10.1162/neco_a_01545
  • Peer Reviewed / Open Access
• [Journal Article] Associations among maternal metabolic conditions, cord serum leptin levels, and autistic symptoms in children. (2021)
  • Author(s): Iwabuchi T, Takahashi N, Nishimura T, Rahman MS, Harada T, Okumura A, Kuwabara H, Takagai S, Nomura Y, Matsuzaki H, Ozaki N, Tsuchiya KJ.
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 816196-816196
  • DOI: 10.3389/fpsyt.2021.816196
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Environmental contributions in the aetiology of autism spectrum disorder (ASD): Current understanding and future perspectives (2023)
  • Author(s): Tsuchiya KJ
  • Organizer: The 11th Congress of the Asian Society for Child and Adolescent Psychiatry and Allied Professions (ASCAPAP2023)
  • Int'l Joint Research
• [Presentation] Is prenatal exposure to per- and polyfluoroalkyl substances (PFAS) associated both with neurodevelopmental delay and neurodevelopmental disorders? (2023)
  • Author(s): Tsuchiya KJ, Rahman MS, Oh J, Shin HM, Takahashi N, Nishimura T
  • Organizer: The 35th Annual Conference of the International Society of Environmental Epidemiology
  • Int'l Joint Research
• [Presentation] Screen time for young children and neurodevelopmental outcomes: Hamamatsu Birth Cohort for Mothers and Children (HBC Study) (2023)
  • Author(s): Tsuchiya KJ, Rahman MS, Takahashi N, Nishimura T
  • Organizer: The 18th Congress of Asian Society of Pediatric Research
  • Int'l Joint Research / Invited
• [Presentation] 胎生期低栄養とグルココルチコイド：妊娠中のたんぱく質摂取とのかかわり (2023)
  • Author(s): 伊東宏晃
  • Organizer: 第7回産学連携シンポジウム
  • Invited
• [Presentation] わが国妊婦の栄養管理の歴史の視点から児の長期的な健康を考える (2023)
  • Author(s): 伊東宏晃
  • Organizer: 第56回小児内分泌学会学術講演会
  • Invited
• [Presentation] 妊婦の栄養摂取不足と次世代のNAFLD発症リスク (2023)
  • Author(s): 伊東宏晃
  • Organizer: 第33回 臨床内分泌代謝Update
  • Invited
• [Presentation] わが国における妊婦の栄養管理の歴史：2021年新たな妊婦の体重増加指導の目安策定までの変遷 (2023)
  • Author(s): 伊東宏晃
  • Organizer: 第42回日本周産期シンポジウム
  • Invited
• [Presentation] 自閉スペクトラム症の環境要因 (2023)
  • Author(s): 松﨑秀夫
  • Organizer: 第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会 合同大会
• [Presentation] 自閉症成人に対する5－アミノレブリン酸リン酸塩の投与効果 (2023)
  • Author(s): 松﨑秀夫
  • Organizer: 第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会 合同大会
• [Presentation] 臍帯血中エポキシ脂肪酸代謝が児の自閉症特性に与える影響 (2023)
  • Author(s): 2.平井孝治、梅田尚子、土屋賢治、西村倫子、松﨑秀夫
  • Organizer: 第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会 合同大会
• [Presentation] ④左右瞳孔径挙動に基づくADHDの判別の検討と数理モデルによる神経活動推定 (2022)
  • Author(s): 信川 創、 熊野 開、白間 綾、髙橋 哲也、武田 俊信、太田 晴久、菊知 充、 岩波 明、加藤 進昌、戸田 重誠
  • Organizer: 日本成人ADHD学会
• [Presentation] 「DOHaD学」と精神神経疾患 (2022)
  • Author(s): 土屋賢治
  • Organizer: フォーラム2022：衛生薬学・環境トキシコロジー
  • Invited
• [Book] 今日の治療指針2024年版 (2024)
  • Author(s): 福井次矢, 高木誠, 小室一成（編集），友田明美ほか（著）
  • Publisher: 医学書院
• [Book] 小児科学 第11版 (2023)
  • Author(s): 加藤元博（編集），友田明美ほか（著）
  • Publisher: 文光堂
• [Book] 子どものこころの診療のコツ 研究のコツ (2023)
  • Author(s): 中村和彦（編集），松﨑秀夫、渡邉賢ほか（著）
  • Total Pages: 232
  • Publisher: 金剛出版
  • ISBN: 9784772420068
• [Book] 発達障がい 病態から支援まで (2022)
  • Author(s): 谷池雅子，清水栄司，辻井正次，土屋賢治，松崎秀夫（編集）
  • Total Pages: 250
  • Publisher: 朝倉書店
• [Remarks]
• [Remarks]
  • URL: http://rccmd.net/
• [Patent(Industrial Property Rights)] 男児における精神神経疾患診断を補助するためのデータの取得方法およびキット (2024)
  • Inventor(s): 松﨑秀夫、平井孝治、土屋賢治、中西広樹
  • Industrial Property Rights Holder: 浜松医科大学，福井大学，（株）リピドームラボ
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2024-045289
  • Filing Date: 2024