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Supply Platform of Short-lived Radioisotopes

Research Project

Project/Area Number 22H04924
Research Category

Grant-in-Aid for Transformative Research Areas (platforms for Advanced Technologies and Research Resources)

Allocation TypeSingle-year Grants
Research InstitutionThe University of Osaka

Principal Investigator

中野 貴志  大阪大学, 核物理研究センター, 教授 (80212091)

Co-Investigator(Kenkyū-buntansha) 菊永 英寿  東北大学, 先端量子ビーム科学研究センター, 准教授 (00435645)
石岡 典子  国立研究開発法人量子科学技術研究開発機構, 高崎量子技術基盤研究所 量子バイオ基盤研究部, 部長 (30354963)
永津 弘太郎  国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 先進核医学基盤研究部, グループリーダー (30531529)
渡部 浩司  東北大学, 先端量子ビーム科学研究センター, 教授 (40280820)
神田 浩樹  大阪大学, 核物理研究センター, 講師 (40321971)
羽場 宏光  国立研究開発法人理化学研究所, 仁科加速器科学研究センター, 室長 (60360624)
福田 光宏  大阪大学, 核物理研究センター, 教授 (60370467)
Project Period (FY) 2022-04-01 – 2028-03-31
Project Status Granted (Fiscal Year 2025)
Budget Amount *help
¥185,640,000 (Direct Cost: ¥142,800,000、Indirect Cost: ¥42,840,000)
Fiscal Year 2026: ¥30,940,000 (Direct Cost: ¥23,800,000、Indirect Cost: ¥7,140,000)
Fiscal Year 2025: ¥30,940,000 (Direct Cost: ¥23,800,000、Indirect Cost: ¥7,140,000)
Fiscal Year 2024: ¥30,940,000 (Direct Cost: ¥23,800,000、Indirect Cost: ¥7,140,000)
Fiscal Year 2023: ¥30,940,000 (Direct Cost: ¥23,800,000、Indirect Cost: ¥7,140,000)
Fiscal Year 2022: ¥30,940,000 (Direct Cost: ¥23,800,000、Indirect Cost: ¥7,140,000)
Keywords放射性同位体 / 短寿命 / 加速器 / アルファ線核医学治療 / シングルフォトン / アルファ線 / α線核医学治療 / 分子イメージング
Outline of Research at the Start

近年とみに需要が増加してきた基礎開発・研究用放射性同位体の年間を通じた安定な供給とその安全な取り扱いのための技術的な支援を行う研究支援基盤を形成します。国内の6か所の加速器施設が緊密に連携し、放射性同位体を安定的にかつ速やかに供給することで、物理、化学、生物学の基礎研究から、工学、農学、薬学、医学分野の応用研究に至る幅広い研究分野の多様な研究者のニーズに応えます。

Outline of Annual Research Achievements

2024年度は上半期のRI供給に向け、2023年12月22日から2024年1月22日までの期間に課題募集を実施し、2024年2月21日に課題選択委員会を開催した。課題選択委員会では申請のあった27課題を審査し、28課題を採択し、1課題を採否保留とした。さらに下半期のRI供給に向けては、7月19日から8月19日までの期間に課題募集を実施し、9月5日に課題選択委員会を開催した。応募のあった課題6課題を審査し、すべての課題を採択した。採択された課題へのRIの供給は、RCNP、東北大RARiS青葉山、東北大RARiS三神峯、理化学研究所、QST高崎研、QST量医研からそれぞれの課題の研究を実施するRI取り扱い施設に対して行った。供給した核種は、核医学治療に向けた研究が精力的に行われているAt-211 が多く、この供給はRCNP、理化学研究所、QST高崎研が主に担当した。そのほか、植物中の元素の動態の研究のためのK-42, K-43、またPET用の核種であるC-11、F-18などの供給を東北大学RARiS三神峯、東北大学RARiS青葉山から実施した。QST量医研では小型サイクロトロンを用いたAc-225の製造と供給を実施した。また、大阪大学放射線科学基盤機構および福島県立医科大学との共催で、短寿命RI利用研究シンポジウムを2024年12月13日から14日の日程でグランフロント大阪にて開催した。国立大学アイソトープ総合センター会議との共催で2024年度放射性同位元素等取扱施設安全管理担当教職員研修を名古屋大学アイソトープ総合センターで2024年10月28日から29日の日程で開催した。RI製造研修会を大阪大学核物理研究センターおよび大阪大学ラジオアイソトープセンターで2025年3月17日から19日までの日程で開催した。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

電力料金が安定してきており、多くの加速器施設で加速器の運転が比較的順調に行われた。
大阪大学核物理研究センターでは定期的なアスタチン-211の製造・供給のほか、研修会に使用する核種の製造などを通して多様な核種の製造と今後の供給に向けた準備が進んだ。QST高崎研では共同利用・共同研究システム形成事業学際領域展開ハブ形成プログラムとの協同を通して、加速器運転時間が確保されRIの製造と供給が安定に行われた。

Strategy for Future Research Activity

文科省の共同利用・共同研究システム形成事業学際領域展開ハブ形成プログラムに、RIコラボラティブ学際領域展開プラットフォーム(学際プラットフォーム)との協同により、技術支援や科研費課題以外の研究課題へのRI供給を広く行うことが可能となった。短寿命RI供給プラットフォームと学際プラットフォームの両輪をもとに、引き続きRI供給を希望する科研費課題に対してRIの製造と供給を行う。

Report

(3 results)
  • 2024 Annual Research Report
  • 2023 Annual Research Report
  • 2022 Annual Research Report
  • Research Products

    (91 results)

All 2025 2024 2023 2022 Other

All Journal Article (51 results) (of which Int'l Joint Research: 37 results,  Peer Reviewed: 49 results,  Open Access: 48 results) Presentation (39 results) (of which Int'l Joint Research: 12 results,  Invited: 23 results) Remarks (1 results)

  • [Journal Article] An 211At-labeled alpha-melanocyte stimulating hormone peptide analog for targeted alpha therapy of metastatic melanoma2025

    • Author(s)
      Suzuki Hiroyuki、Yamashita Saki、Tanaka Shoko、Kannaka Kento、Sasaki Ichiro、Ohshima Yasuhiro、Watanabe Shigeki、Ooe Kazuhiro、Watabe Tadashi、Ishioka Noriko S.、Tanaka Hiroshi、Uehara Tomoya
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: 52 Issue: 6 Pages: 2107-2117

    • DOI

      10.1007/s00259-024-07056-3

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation cross-sections of proton-induced nuclear reactions on natural zinc in the energy range of 4?30?MeV2025

    • Author(s)
      Khandaker Mayeen Uddin、Haba Hiromitsu、Usman Ahmed Rufai、Mahmoud Mustafa、Otuka Naohiko、Ali Samer K.I.
    • Journal Title

      Radiation Physics and Chemistry

      Volume: 226 Pages: 112272-112272

    • DOI

      10.1016/j.radphyschem.2024.112272

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation cross sections of 7Li-induced reactions on natTi: Implications for monitor reactions2025

    • Author(s)
      Aikawa Masayuki、Goto Saki、Gantumur Damdinsuren、Ichinkhorloo Dagvadorj、Ukon Naoyuki、Otuka Naohiko、Takacs Sandor、Haba Hiromitsu
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms

      Volume: 559 Pages: 165579-165579

    • DOI

      10.1016/j.nimb.2024.165579

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Utilities of ionic liquid extraction with astatine ions and its extraction mechanism2025

    • Author(s)
      Yokoyama Akihiko、Kawasaki Kohei、Nagai Yuta、Tazuru Hisanori、Shimizu Yusuke、Ganaha Kohya、Washiyama Kohshin、Nishinaka Ichiro、Wang Yang、Yin Xiaojie、Sato Nozomi、Nambu Akihiro、Shigekawa Yudai、Haba Hiromitsu
    • Journal Title

      Radiochimica Acta

      Volume: 113 Issue: 5 Pages: 373-384

    • DOI

      10.1515/ract-2024-0357

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Measurement of activation cross section of alpha-particle induced nuclear reactions on dysprosium2025

    • Author(s)
      Takacs S.、Ditroi F.、Szucs Z.、Aikawa M.、Haba H.、Usuda S.、Ebata S.
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms

      Volume: 563 Pages: 165670-165670

    • DOI

      10.1016/j.nimb.2025.165670

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The production study of Auger emitters in platinum group metal for radiotherapy2024

    • Author(s)
      Ohya Tomoyuki
    • Journal Title

      Impact

      Volume: 2024 Issue: 2 Pages: 53-55

    • DOI

      10.21820/23987073.2024.2.53

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of LAT1-Selective Nuclear Medicine Therapeutics Using Astatine-2112024

    • Author(s)
      Kaneda-Nakashima Kazuko、Shirakami Yoshifumi、Hisada Kentaro、Feng Sifan、Kadonaga Yuichiro、Ooe Kazuhiro、Watabe Tadashi、Manabe Yoshiyuki、Shimoyama Atsushi、Murakami Masashi、Toyoshima Atsushi、Haba Hiromitsu、Kanai Yoshikatsu、Fukase Koichi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 25 Issue: 22 Pages: 12386-12386

    • DOI

      10.3390/ijms252212386

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Production of [211At]NaAt solution under GMP compliance for investigator-initiated clinical trial2024

    • Author(s)
      Naka Sadahiro、Ooe Kazuhiro、Shirakami Yoshifumi、Kurimoto Kenta、Sakai Toshihiro、Takahashi Kazuhiro、Toyoshima Atsushi、Wang Yang、Haba Hiromitsu、Kato Hiroki、Tomiyama Noriyuki、Watabe Tadashi
    • Journal Title

      EJNMMI Radiopharmacy and Chemistry

      Volume: 9 Issue: 1 Pages: 29-29

    • DOI

      10.1186/s41181-024-00257-z

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation cross sections of α-particle-induced reactions on scandium in the energy range of 22?51?MeV2024

    • Author(s)
      Aikawa Masayuki、Ebata Shuichiro、Haba Hiromitsu、Tak?cs S?ndor、Ditr?i Ferenc、Sz?cs Zolt?n
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms

      Volume: 550 Pages: 165315-165315

    • DOI

      10.1016/j.nimb.2024.165315

    • Related Report
      2024 Annual Research Report 2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison Length of Linker in Compound for Nuclear Medicine Targeting Fibroblast Activation Protein as Molecular Target2024

    • Author(s)
      Hisada Kentaro、Kaneda-Nakashima Kazuko、Shirakami Yoshifumi、Kadonaga Yuichiro、Saito Atsuko、Watabe Tadashi、Feng Sifan、Ooe Kazuhiro、Yin Xiaojie、Haba Hiromitsu、Murakami Masashi、Toyoshima Atsushi、Cardinale Jens、Giesel Frederik L.、Fukase Koichi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 25 Issue: 22 Pages: 12296-12296

    • DOI

      10.3390/ijms252212296

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation cross sections of alpha-particle-induced reactions on natural rhenium up to 50?MeV2024

    • Author(s)
      Gantumur Damdinsuren、Aikawa Masayuki、Khishigjargal Tegshjargal、Norov Erdene、Ebata Shuichiro、Haba Hiromitsu、Takacs Sandor、Ditroi Ferenc、Szucs Zoltan
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 213 Pages: 111486-111486

    • DOI

      10.1016/j.apradiso.2024.111486

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Preclinical Evaluation of Biodistribution and Toxicity of [211At]PSMA-5 in Mice and Primates for the Targeted Alpha Therapy against Prostate Cancer2024

    • Author(s)
      Watabe Tadashi、Kaneda-Nakashima Kazuko、Kadonaga Yuichiro、Ooe Kazuhiro、Sampunta Thosapol、Hirose Naoki、Yin Xiaojie、Haba Hiromitsu、Kon Yukiyoshi、Toyoshima Atsushi、Cardinale Jens、Giesel Frederik L.、Fukase Koichi、Tomiyama Noriyuki、Shirakami Yoshifumi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 25 Issue: 11 Pages: 5667-5667

    • DOI

      10.3390/ijms25115667

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isomer production studied with simultaneous decay curve analysis for alpha-particle induced reactions on natural platinum up to 29?MeV2024

    • Author(s)
      Otuka Naohiko、Takacs Sandor、Aikawa Masayuki、Ebata Shuichiro、Haba Hiromitsu
    • Journal Title

      The European Physical Journal A

      Volume: 60 Issue: 9

    • DOI

      10.1140/epja/s10050-024-01383-7

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Excitation functions of the α-particle-induced reactions on natCr up to 50?MeV2024

    • Author(s)
      Ukon N.、Aikawa M.、Komori Y.、Haba H.、Ditroi F.、Takacs S.
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms

      Volume: 552 Pages: 165348-165348

    • DOI

      10.1016/j.nimb.2024.165348

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Solvent extraction of astatine by DIPE and attempt to identify the extracted species by thin layer chromatography2024

    • Author(s)
      Taniguchi Takumi、Maruyama Shunpei、Aoi Keito、Nagai Yuta、Washiyama Kohshin、Nishinaka Ichiro、Wang Yang、Haba Hiromitsu、Yokoyama Akihiko
    • Journal Title

      Journal of Radioanalytical and Nuclear Chemistry

      Volume: 333 Issue: 8 Pages: 3937-3945

    • DOI

      10.1007/s10967-024-09547-x

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Activation cross sections of 7Li-induced reactions on natCu for monitor reactions2024

    • Author(s)
      Aikawa Masayuki、Goto Saki、Gantumur Damdinsuren、Ichinkhorloo Dagvadorj、Ukon Naoyuki、Otuka Naohiko、Takacs Sandor、Haba Hiromitsu
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms

      Volume: 554 Pages: 165441-165441

    • DOI

      10.1016/j.nimb.2024.165441

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a large-scale production system of astatine-211 for targeted alpha-particle therapy2024

    • Author(s)
      H. Arata, T. Kurihara, S. Nakamura, N. Sato, X. Yin, A. Nambu, Y. Shigekawa, Y. Kanayama, H. Arai, Y. Nagasawa, and H. Haba
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 7Li-induced reactions on natCu for monitor reactions2024

    • Author(s)
      M. Aikawa, S. Goto, G. Damdinsuren, D. Ichinkhorloo, N. Ukon, and H. Haba
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PET image background reduction of prompt γ emitting 86Y through quantum entanglement property of annihilation γ rays2024

    • Author(s)
      D. Kim, Y. Shigekawa, A. Nambu, K. Shimazoe, and H. Haba
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 126-127

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Solvent extraction of Zr and Hf using soft ligands toward chemical study of Rf2024

    • Author(s)
      Y. Itakura, R. Wang, M. Konno, K. Shibamoto, Y. Shigekawa, A. Nambu, H. Haba, K. Nagata, M. Kaneko, and Y. Kasamatsu
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 148-148

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modification of 211At production apparatus to increase its production efficiency2024

    • Author(s)
      X. Yin, N. Sato, A. Nambu, Y. Kanayama, Y. Shigekawa, and H. Haba
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 149-150

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Investigation of radiopharmaceutical labeling of 141Ce with DOTA2024

    • Author(s)
      K. Ooe, T. Watabe, Y. Shirakami, A. Nambu, H. Haba, and J. Hatazawa
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 165-166

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of 211At recovery rates in glass vials and plastic tubes2024

    • Author(s)
      T. Tatsumi, T. Tanaka, A. Sugiyama, J. Jang, M. Kobayashi, Y. Kumakura, X. Yin, H. Haba, and Y. Wada
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 167-167

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of tumor size on the accumulation of 67Cu-labeled compounds targeting the somatostatin receptor in tumor2024

    • Author(s)
      Y. Fujisawa, Y. Sugiura, H. Haba, A. Nambu, Y. Shigekawa, X. Yin, Y. Magata, and Y. Iida
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 168-168

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation cross sections of α-particle-induced reactions on scandium2024

    • Author(s)
      M. Aikawa, S. Ebata, H. Haba, S. Takacs, F. Ditroi, and Z. Szucs
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 169-169

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation cross sections of proton-induced reactions on manganese up to 30 MeV2024

    • Author(s)
      H. Huang, M. Aikawa, D. Gantumur, and H. Haba
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 170-170

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Production cross-sections of 61Cu in α-particle-induced reaction on 59Co2024

    • Author(s)
      G. Damdinsuren, M. Aikawa, S. Goto, D. Ichinkhorloo, N. Ukon, and H. Haba
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 171-172

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cyclotron production of 62Zn generator radioisotope via natZn(p,x)62Zn2024

    • Author(s)
      M. U. Khandaker, H. Haba, and A. R. Usman
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 173-173

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cross sections of 155Tb and 156Tb via α-particle induced reactions on natEu2024

    • Author(s)
      Y. Shigekawa and H. Haba
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 174-175

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Production cross-sections of dysprosium-159 radioisotope from alpha-particle-induced reaction on natural terbium up to 50 MeV2024

    • Author(s)
      D. Ichinkhorloo, M. Aikawa, Ts. Zolbadral, S. Goto, G. Damdinsuren, N. Ukon, and H. Haba
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 176-176

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation cross-sections of α-particle-induced reactions on natDy2024

    • Author(s)
      S. Takacs, F. Ditroi, Z. Szucs, H. Haba, S. Usuda, M. Aikawa, and S. Ebata
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 177-177

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation cross sections of α-particle-induced reactions on natTa2024

    • Author(s)
      S. Takacs, F. Ditroi, Z. Szucs, M. Aikawa, G. Damdinsuren, H. Haba, and S. Ebata
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 178-178

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cross sections of proton-induced reactions on natW for 186gRe production2024

    • Author(s)
      M. Aikawa, S. Ebata, N. Ukon, and H. Haba
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 179-180

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation cross sections of alpha-particle-induced reactions on natural tungsten for osmium and rhenium radionuclides2024

    • Author(s)
      N. Ukon, M. Aikawa, M. Saito, M. Hagiwara, H. Yashima, Y. Komori, H. Haba, S. Takacs, F. Ditroi, and Z. Szucs,
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 181-182

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation cross sections of deuteron-induced reactions on natural rhenium2024

    • Author(s)
      M. Aikawa, Y. Toyoeda, D. Gantumur, N. Ukon, S. Ebata, H. Haba, S. Takacs, F. Ditroi, and Z. Szucs
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 57 Pages: 183-183

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation cross sections of alpha-particle-induced reactions on natural tungsten for osmium and rhenium radionuclides2023

    • Author(s)
      Ukon Naoyuki、Aikawa Masayuki、Saito Moemi、Hagiwara Masayuki、Yashima Hiroshi、Komori Yukiko、Haba Hiromitsu、Tak?cs S?ndor、Ditr?i Ferenc、Sz?cs Zolt?n
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms

      Volume: 539 Pages: 95-101

    • DOI

      10.1016/j.nimb.2023.03.032

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation cross section measurement of alpha-particle induced nuclear reactions on tantalum2023

    • Author(s)
      Takacs S.、Ditroi F.、Szucs Z.、Aikawa M.、Haba H.、Toyoeda Y.、Damdinsuren G.、Ebata S.
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms

      Volume: 545 Pages: 165127-165127

    • DOI

      10.1016/j.nimb.2023.165127

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Solvent extraction following oxidation of astatine for the use of a 211Rn - 211At generator2023

    • Author(s)
      Shin Yuki、Maruyama Shunpei、Kawasaki Kohei、Aoi Keito、Washiyama Kohshin、Nishinaka Ichiro、Yano Shinya、Haba Hiromitsu、Yokoyama Akihiko
    • Journal Title

      Journal of Radioanalytical and Nuclear Chemistry

      Volume: 333 Issue: 1 Pages: 403-409

    • DOI

      10.1007/s10967-023-09282-9

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simultaneous multi-nuclide imaging via reconstruction-free double-photon emission coincidence imaging method with parallel hole collimator and slat collimator2023

    • Author(s)
      Yan Linlin、Uenomachi Mizuki、Ueki Taisei、Kim Donghwan、Shimazoe Kenji、Takahashi Hiroyuki、Kamada Kei、Shigekawa Yudai、Nambu Akihiro、Yin Xiaojie、Wang Yang、Haba Hiromitsu
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

      Volume: 1053 Pages: 168305-168305

    • DOI

      10.1016/j.nima.2023.168305

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevention of radionuclide-induced antibody denaturation maintains active targeting and maximizes antitumor efficacy in 211At-radioimmunotherapy2023

    • Author(s)
      H. Takashima, K. Ohnuki, S. Manabe, Y. Koga, R. Tsumura, T. Anzai, Y. Wang, X. Yin, N. Sato, Y. Shigekawa, A. Nambu, S. Usuda, H. Haba, H. Fujii, and M. Yasunaga
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 56

    • Related Report
      2023 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] Progress on double photon coincidence imaging with 67Cu and 169Yb2023

    • Author(s)
      K. Shimazoe, M. Uenomachi, H. Takahashi, Y. Shigekawa, A. Nambu, X. Yin, and H. Haba
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 56 Pages: 110-110

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of 211Rn/211At generator through liquid phase recovery of radon and ionic liquid extraction of astatine2023

    • Author(s)
      Y. Nagai, Y. Ganaha, A. Yokoyama, K. Washiyama, I. Nishinaka, X. Yin, A. Nambu, Y. Shigekawa, and H. Haba
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 56 Pages: 149-149

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The feasibility study for the medical radioisotope: astatine-211 production by the gas cell-based laser ionization technique2023

    • Author(s)
      T. Sonoda, T. Nakashita, H. Haba, H. Tomita, and H. Ishiyama
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 56 Pages: 150-150

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Progress of 211At production at the RIKEN AVF cyclotron2023

    • Author(s)
      X. Yin, N. Sato, A. Nambu, Y. Shigekawa, and H. Haba
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 56 Pages: 151-151

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improvement of chemical separation method for theranostic radionuclide 141Ce2023

    • Author(s)
      K. Ooe, T. Watabe, Y. Shirakami, A. Nambu, H. Haba, and J. Hatazawa
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 56 Pages: 153-153

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of nuclear medicine therapy with 67CuCl2 in mice bearing LS180 colon cancer2023

    • Author(s)
      Y. Fujisawa, Y. Sugiura, H. Haba, A. Nambu, Y. Shigekawa, X. Yin, Y. Magata, and Y. Iida
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 56 Pages: 156-157

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation cross sections of 28Mg via α-particle-induced reaction on Al2023

    • Author(s)
      M. Aikawa, H. Huang, G. Damdinsuren, S. Ebata, H. Haba, S. Takacs, F. Ditroi, and Z. Szucs
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 56 Pages: 165-166

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Production cross sections of 47Sc via α-particle induced reactions on natCa2023

    • Author(s)
      M. Aikawa, Y. Hanada, D. Ichinkhorloo, H. Haba, S. Takacs, F. Ditroi, and Z. Szucs
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 56 Pages: 167-168

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Activation cross sections of α-particle-induced reactions on natTa2023

    • Author(s)
      S. Takacs, F. Ditroi, Z. Szucs, M. Aikawa, G. Damdinsuren, H. Haba, and S. Ebata
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 56 Pages: 178-179

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation cross sections of deuteron-induced reactions on natRe2023

    • Author(s)
      M. Aikawa, Y. Toyoeda, G. Damdinsuren, S. Ebata, H. Haba, S. Takacs, F. Ditroi, and Z. Szucs
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 56 Pages: 180-180

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Production cross sections of 211Rn via 7Li-induced reaction on 209Bi2023

    • Author(s)
      N. Ukon, K. Washiyama, M. Aikawa, G. Damdinsuren, S. Ebata, and H. Haba
    • Journal Title

      RIKEN Accel. Prog. Rep.

      Volume: 56 Pages: 185-185

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 短寿命RI 供給プラットホーム2024

    • Author(s)
      神田浩樹
    • Organizer
      令和6年度(秋季)放射線安全管理研修会
    • Related Report
      2024 Annual Research Report
    • Invited
  • [Presentation] 新たなバイオマーカー開発の現状: [18F]SMBT-1 PET2024

    • Author(s)
      田代学
    • Organizer
      第66回日本老年医学会総会、シンポジウム43
    • Related Report
      2024 Annual Research Report
    • Invited
  • [Presentation] 放射性核種の診断治療への応用2024

    • Author(s)
      田代学
    • Organizer
      日本バイオマテリアル学会シンポジウム2024、「診断・計測・イメージング」
    • Related Report
      2024 Annual Research Report
    • Invited
  • [Presentation] [18F]SMBT-1 PET を用いた反応性アストロサイトイメージングの臨床有用性2024

    • Author(s)
      田代学
    • Organizer
      第43回日本認知症学会学術総会、シンポジウム
    • Related Report
      2024 Annual Research Report
    • Invited
  • [Presentation] 革新的技術への核医学領域からの期待 (Future prospects on revolutionary technologies from nuclear medicine field).2024

    • Author(s)
      田代学
    • Organizer
      日本医学放射線学会、合同シンポジウム3「未知の放射線医学を先導する科学技術」
    • Related Report
      2024 Annual Research Report
    • Invited
  • [Presentation] 神経炎症イメージングのためのPET薬剤 [18F]SMBT-1の動態解析2024

    • Author(s)
      平岡宏太良、菊地飛鳥、船木善仁、原田龍一、石木愛子、古本祥三、岡村信行、菊池昭夫、渡部浩司、*田代学
    • Organizer
      第64回日本核医学会学術総会
    • Related Report
      2024 Annual Research Report
  • [Presentation] 反応性アストログリオーシスを定量化する新規画像バイオマーカーの研究開発:認知症疾患の層別化における[18F]SMBT-1の有用性の検討2024

    • Author(s)
      田代学*, 平岡宏太良, 冨田尚希, 小林良太, Wu Yingying, TEKEA Berihu,原田龍一, 菊地飛鳥, 菊地飛鳥, 武田和子, 草場美津江, 菊池昭夫, 古川勝敏, 渡部浩司, 麦倉俊司, 川勝忍, 石井賢二, 加藤隆司, 古本祥三, 岡村信行.
    • Organizer
      第43回日本認知症学会学術集会,
    • Related Report
      2024 Annual Research Report
  • [Presentation] 反応性アストログリオーシスを定量化する新規画像バイオマーカーの研究開発:認知症疾患の層別化における[18F]SMBT-1の有用性の検討(最終報告)2024

    • Author(s)
      田代学*、Wu Yingying, Mesfin Berihu, 平岡宏太良、四月朔日聖一、麦倉俊司、冨田尚希、菊池昭夫、古川勝敏、川勝忍、小林良太、渡部浩司、石井賢二、加藤隆司、古本祥三、岡村信行
    • Organizer
      第 150回日本医学放射線学会北日本地方会・第95回日本核医学会北日本地方会
    • Related Report
      2024 Annual Research Report
  • [Presentation] 健常者、 MCI、AD患者におけるアストログリオーシス所見2024

    • Author(s)
      Wu Yingying、Mesfin Berihu 、平岡宏太良、菊地飛鳥、四月朔日聖一、麦倉俊司、冨田尚希、古川勝敏、渡部浩司、小林良太、石井賢二、加藤隆司、古本祥三、岡村信行、*田代学*
    • Organizer
      第150回日本医学放射線学会北日本地方会・第95回日本核医学会北日本地方会.
    • Related Report
      2024 Annual Research Report
  • [Presentation] 新規PETトレーサー[18F]SMBT-1のヒトにおける全身被ばく評価2024

    • Author(s)
      一之瀬圭規、メスフィン・ベリフ、石岡有生、四月朔日聖一、三宅正泰、志田原美保、平岡宏太良、菊地飛鳥、原田龍一、古本祥三、岡村信行、渡部浩司、 *田代学*
    • Organizer
      第150回日本医学放射線学会北日本地方会・第95 回日本核医学会北日本地方会
    • Related Report
      2024 Annual Research Report
  • [Presentation] RI利用展開のための放射線管理について2024

    • Author(s)
      渡部浩司
    • Organizer
      第2回短寿命RI利用研究シンポジウム
    • Related Report
      2024 Annual Research Report
  • [Presentation] アルファ線核医学治療用アスタチン-211の大規模製造装置の開発2024

    • Author(s)
      安良田 寛,栗原 嵩司,中村 伸悟,荒井 秀幸,佐藤 望,殷小 杰,南部 明弘,重河 優大,金山 洋介, 渡邉 環, ミトラ サヤンタニ, 長澤 豊,羽場 宏光
    • Organizer
      第2回短寿命RI利用研究シンポジウム
    • Related Report
      2024 Annual Research Report
  • [Presentation] がんの治療に新元素合成で貢献2024

    • Author(s)
      羽場 宏光
    • Organizer
      第28 回日本がん分子標的治療学会学術集会
    • Related Report
      2024 Annual Research Report
    • Invited
  • [Presentation] Production and Applications of Radioisotopes at RIKEN RI Beam Factory -Search for New Elements through Therapy of Cancer-2024

    • Author(s)
      H. Haba
    • Organizer
      XIth DAE-BRNS Symposium on Emerging Trends in Separation Science and Technology (SESTEC-2024)
    • Related Report
      2024 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 理研における医療用ラジオアイソトープ製造の現状と今後2024

    • Author(s)
      羽場宏光
    • Organizer
      日本薬学会第145年会
    • Related Report
      2024 Annual Research Report
    • Invited
  • [Presentation] Production of Medical Radioisotopes at RIKEN RI Beam Factory2024

    • Author(s)
      H. Haba
    • Organizer
      Symposium on Nuclear Data 2024
    • Related Report
      2024 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rfの化学的性質解明に向けたソフトドナーによるZr, Hfの溶媒抽出2024

    • Author(s)
      板倉悠大, 金子政志, 風間裕行, 永田光知郎, 王瑞麟, 紺野未夢, KhultEnni, 柴本恭佑, 羽場宏光, 金山洋介, 重河優大, 南部明弘, 笠松良崇
    • Organizer
      日本放射化学討論会第68回討論会(2024)
    • Related Report
      2024 Annual Research Report
  • [Presentation] Rfの化学研究に向けたDGA を用いた4族元素の固液抽出実験及び機械学習手法の応用2024

    • Author(s)
      柴本恭佑, 金子政志, 風間裕行, 王瑞麟, Khult Enni, 板倉悠大, 紺野未夢, 重河優大, 殷小杰, 金山洋介, 南部明弘, 羽場宏光, 塚原聡, 笠松良崇
    • Organizer
      日本放射化学討論会第68回討論会(2024)
    • Related Report
      2024 Annual Research Report
  • [Presentation] Production and applications of radioisotopes at RIKEN RI Beam Factory -Search for new elements through therapy of cancer-2024

    • Author(s)
      H. Haba
    • Organizer
      The 1st Conference of Accelerator-Based Science and Technology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Progress of 211At production at the RIKEN AVF cyclotron2024

    • Author(s)
      殷小杰,佐藤望,重河優大,南部明弘,羽場宏光
    • Organizer
      第60回アイソトープ・放射線研究発表会
    • Related Report
      2023 Annual Research Report
  • [Presentation] RI製造の現状と施設への期待2023

    • Author(s)
      羽場宏光
    • Organizer
      J-PARC陽子照射施設検討に関する研究会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] ラジオアイソトープの製造と応用~新元素の探索からがん治療まで~2023

    • Author(s)
      羽場宏光
    • Organizer
      短寿命RI 利用研究シンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Production and applications of radioisotopes at RIKEN RI Beam Factory - Search for new elements through therapy of cancer -2023

    • Author(s)
      H. Haba
    • Organizer
      5th International Conference on "Physics for Sustainable Development & Technology” (ICPSDT-2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] サイクロトロンを用いた医療用ラジオアイソトープの製造2023

    • Author(s)
      羽場宏光
    • Organizer
      日本物理学会第78回年次大会(2023年)
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Production of astatine-211 for targeted α-particle therapy at RIBF2023

    • Author(s)
      H. Haba
    • Organizer
      8th High Power Targetry Workshop
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 理研におけるラジオアイソトープの製造と応用~新元素の探索からがん治療まで~2023

    • Author(s)
      羽場宏光
    • Organizer
      日本量子医科学会第3回学術大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Status of the Short-Lived Radioisotope Supplying Platform in Japan2023

    • Author(s)
      Hiroki Kanda, Takashi Nakano, Mitsuhiro Fukuda
    • Organizer
      11th International Conference on Isotopes
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] サイクロトロンによる医療用RIの製造 ~アルファ線放出核種(At-211、Ac-225)を中心に~2023

    • Author(s)
      永津 弘太郎
    • Organizer
      第20回 日本加速器学会年会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Production of Radioisotopes for Application Studies at RIKEN RI Beam Factory ?Search for New Elements through Diagnosis and Therapy of Cancer2023

    • Author(s)
      Hiromitsu Haba
    • Organizer
      The Fifth International Conference on Application of RadiotraCers and Energetic Beams in Sciences (ARCEBS 2023)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synthesis of Radioactive Isotope for Gamma-ray Imaging2023

    • Author(s)
      Hiromitsu Haba
    • Organizer
      Workshop on Double Photon Emission Computed Tomography and beyond
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Supply platform of short-lived radioisotopes in Japan2022

    • Author(s)
      Takashi Nakano
    • Organizer
      PRISMAP workshop on emerging infrastructures and technical developments
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Production and distribution of radioisotopes at RIKEN RI Beam Factory2022

    • Author(s)
      Hiromitsu Haba
    • Organizer
      PRISMAP workshop on emerging infrastructures and technical developments
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 合金化を用いた簡便な103Pd分離精製法の開発2022

    • Author(s)
      矢 智幸, 永津 弘太郎, 峯岸 克行, 張 明栄
    • Organizer
      第62回日本核医学会学術総会, 日本核医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] RIイメージングを活用した研究を展開したい研究者への支援について(植物研究を中心に)2022

    • Author(s)
      河地 有木, 鈴井 伸郎, 渡部 浩司, 田野井 慶太朗, 古川 純
    • Organizer
      第59回アイソトープ・放射線研究発表会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Production and Applications of Radioisotopes at RIKEN RI Beam Factory - Search for New Elements through Diagnosis and Therapy of Cancer -2022

    • Author(s)
      Hiromitsu Haba
    • Organizer
      Laser Solutions for Space and the Earth 2022, in OPTICS & PHOTONICS International Congress 2022 (OPIC 2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Production and Applications of Radioisotopes at RIKEN RI Beam Factory ? Search for New Elements through Diagnosis and Therapy of Cancer ?2022

    • Author(s)
      Hiromitsu Haba
    • Organizer
      IAEA/RCA RTC on Good Manufacturing Practice (GMP) and Radiation Safety Aspects of Radiopharmaceutical Production Using Medical Cyclotron
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新元素でがん治療-RIBFがつくるラジオアイソトープ-2022

    • Author(s)
      羽場宏光
    • Organizer
      理研と未来を創る会第28回講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ラジオアイソトープの製造を通じた産業振興2022

    • Author(s)
      羽場宏光
    • Organizer
      シンポジウム「理化学研究所仁科研究室のキセキ」
    • Related Report
      2022 Annual Research Report
  • [Presentation] 新元素でがん治療~理研RIビームファクトリーがつくるラジオアイソトープ~2022

    • Author(s)
      羽場宏光
    • Organizer
      放射線安全フォーラム 第75回放射線防護研究会「短寿命核種の利用の拡大に向けて」
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Remarks] 大阪大学核物理研究所 短寿命RI供給プラットフォーム

    • URL

      https://www.rcnp.osaka-u.ac.jp/~ripf/

    • Related Report
      2024 Annual Research Report

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Published: 2022-04-19   Modified: 2026-04-10  

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