| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2024: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Our body maintains homeostasis by quickly responding to oxidative stress and environmental toxic stress. Impairment of the stress response systems is closely related to the onset of various diseases. The stress sensor Keap1 is a key factor that plays a central role in defense mechanism by controlling the ubiquitination reaction of the transcription factor Nrf2. Although the sensor cysteine residues in Keap1 have been identified, the mechanism by which this control system regulates Nrf2 activity remains unknown. In this study, we aimed to elucidate the molecular basis of the mechanism by which Keap1-Nrf2 regulates stress response through animal experiments and structure analysis.
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