Investigating the role of epithelial cell-derived IL23A in immunity and infla mmation-associated carcinogenesis

Research Project

Project/Area Number	22K07209
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 50010:Tumor biology-related
Research Institution	Kanazawa University
Principal Investigator	Dominic Voon 金沢大学, がん進展制御研究所, 准教授 (30776878)
Project Period (FY)	2022-04-01 – 2025-03-31
Project Status	Granted (Fiscal Year 2022)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2023: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords	Epithelial IL23A / Inflammation / carcinogenesis / immunity
Outline of Research at the Start	We aim to study the role of IL23A produced by epithelial cells in infection, inflammation and tumor immunity. We use ex vivo primary leukocytes and cell lines to examine its immunological function and mouse genetics models to study its physiological roles during infection and carcinogenesis.