| Project/Area Number |
22K07768
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Gifu University |
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Principal Investigator |
NODA YOSHIFUMI 岐阜大学, 大学院医学系研究科, 招へい教員 (60643020)
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| Co-Investigator(Kenkyū-buntansha) |
兵藤 文紀 岐阜大学, 大学院医学系研究科, 教授 (10380693)
河合 信行 岐阜大学, 医学部附属病院, 講師 (20724561)
加賀 徹郎 岐阜大学, 大学院医学系研究科, 助教 (20897334)
加藤 博基 岐阜大学, 大学院医学系研究科, 准教授 (70377670)
松尾 政之 岐阜大学, 大学院医学系研究科, 教授 (40377669)
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| Project Period (FY) |
2022-04-01 – 2025-03-31
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| Project Status |
Completed (Fiscal Year 2024)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 膵癌 / MRI |
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| Outline of Research at the Start |
近年、重水素化分子プローブに基づくdeuterium metabolic MRI (dMRI)が注目され始めたが、4.7～11.4-Tの高磁場MRIを使用しており実臨床への応用にはほど遠い。本研究では、実臨床で用いられるMRI（1.5-もしくは3-T）で実現可能なdMRIによる重水素を指標とした代謝イメージング法を確立し、小径膵癌の描出や術前抗癌剤治療効果の早期診断を目的とする。
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| Outline of Final Research Achievements |
MIA PaCa-2 pancreatic cancer-bearing mice were generated and given 30% deuterium water ad libitum while repeated 2H-MRI was performed for 10 days after the initial administration to visualize and follow the distribution of 2H throughout the body and into the tumor. Image analysis allowed us to observe the accumulation of deuterium in the mouse body over time, especially in tumor. In addition, anticancer treatments of radiation, bevacizumab, and gemcitabine were administered, and the 2H signal changes after treatment were analyzed. The results showed that although there was no obvious change in tumor size after 1-3 days of treatment, the 2H signal was significantly decreased, reflecting the metabolic changes in the tumor caused by the treatment.
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| Academic Significance and Societal Importance of the Research Achievements |
1.5T臨床MRIを用いた2H-MRIは、がん代謝変化の非侵襲的可視化および早期治療効果判定に有効であることが示された。今後、ヒトを対象とした臨床応用に向けた発展が期待される。
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