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脂質シャペロンと代謝性脂肪肝疾患が関わる腎臓病発症機序の解明

Research Project

Project/Area Number 22K08313
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53040:Nephrology-related
Research InstitutionSapporo Medical University

Principal Investigator

田中 希尚  札幌医科大学, 医学部, 研究員 (60533362)

Co-Investigator(Kenkyū-buntansha) 古橋 眞人  札幌医科大学, 医学部, 教授 (20563852)
Project Period (FY) 2022-04-01 – 2025-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2024: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2022: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsFABP4 / CKD / MAFLD / 虚血性心疾患 / Fatty liver index / 糖尿病 / 高血圧 / 脂質異常症 / 脂肪酸結合タンパク4 / 慢性腎臓病 / 代謝異常関連脂肪肝疾患 / メタボリックシンドローム / 糸球体障害 / 糸球体内皮細胞 / 小胞体ストレス / アディポカイン / 代謝性脂肪肝疾患 / 脂質シャペロン / 肝障害と腎障害の臓器連関
Outline of Research at the Start

心血管疾患や新型コロナウイルス感染症の重症化に関わる肥満や慢性腎臓病(CKD)、代謝性脂肪肝疾患(MAFLD)は現代人の重要な公衆衛生上の課題である。脂質シャペロンの一つである脂肪酸結合タンパク4 (FABP4)は主に脂肪細胞に発現し、脂肪肝や肥満、メタボリックシンドロームのみならず、腎障害にも関連する。本研究ではFABP4が介在するCKDとMAFLDの臓器連関のメカニズムを明らかにし、新たな腎疾患治療薬としてFABP4をターゲットとした治療の可能性を探る。

Outline of Annual Research Achievements

大規模健診データを用いた検討により、過体重/肥満、2型糖尿病または代謝調節不全を伴う脂肪肝として定義された代謝異常関連脂肪性肝疾患(MAFLD)が慢性腎臓病(CKD)のリスク因子となることを報告し、MAFLDとCKDの併存が新規虚血性心疾患の強いリスク要因となることを示した。更に近年、社会実装が普及している人工知能を用いてCKD発症に強く関わる高血圧及び糖尿病の予測モデルを検討したところ、高血圧発症は収縮期血圧、年齢、fatty liver index、糖尿病発症はHbA1cとfatty liver indexで構成される機械学習モデルによって高精度に予測されることを報告した。CKDのリスクをして以前報告したLDLコレステロールのうち、small dense-LDLコレステロールが新規高血圧の発症および新規虚血性心疾患のリスク因子となることを見出した。一方、MAFLDとFABP4が関連することは以前示したが、糖尿病患者を対象としたコホート研究において、血漿FABP4は腎機能やBMIと有意な相関を示し、腎予後予測因子として確立されつつあるTNF receptor1及びTNF receptor 2と強い相関があることを確認した。更に糖尿病性腎症とその動物モデルであるKK-TA/Akitaマウスの腎組織解析においてFABP4が糸球体内で検出され、コントロールに比較してその発現量が有意に強く、尿FABP4排泄量が腎機能や尿中アルブミン濃度と強く相関することを確認した。以上より尿及び血漿FABP4濃度は糖尿病で引き起こされる腎障害に関与し、新規の腎予後予測因子となり得る可能性がある。代謝障害やFABP4を含む脂質代謝異常はMAFLDとともにCKDを含む多臓器障害の発症に関連し、特にMAFLDとCKDの合併は予後規定因子となる心疾患の強い発症要因となり得る。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

研究実施計画を順調にこなしている。

Strategy for Future Research Activity

現在進行中の検討を継続していく。

Report

(2 results)
  • 2023 Research-status Report
  • 2022 Research-status Report
  • Research Products

    (43 results)

All 2024 2023 2022 Other

All Journal Article (25 results) (of which Peer Reviewed: 25 results,  Open Access: 23 results) Presentation (17 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Validation of Estimated Small Dense Low-Density Lipoprotein Cholesterol Concentration in a Japanese General Population2024

    • Author(s)
      Endo Keisuke、Kobayashi Ryo、Tanaka Makito、Tanaka Marenao、Akiyama Yukinori、Sato Tatsuya、Hosaka Itaru、Nakata Kei、Koyama Masayuki、Ohnishi Hirofumi、Takahashi Satoshi、Furuhashi Masato
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 31 Issue: 6 Pages: 931-952

    • DOI

      10.5551/jat.64578

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2024-06-01
    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Calculated Small Dense Low-Density Lipoprotein Cholesterol Level is A Predominant Predictor for New Onset of Ischemic Heart Disease2024

    • Author(s)
      Inyaku Masafumi、Tanaka Marenao、Sato Tatsuya、Endo Keisuke、Mori Kazuma、Hosaka Itaru、Mikami Takuma、Umetsu Araya、Ohnishi Hirofumi、Akiyama Yukinori、Hanawa Nagisa、Furuhashi Masato
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 31 Issue: 3 Pages: 232-248

    • DOI

      10.5551/jat.64369

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2024-03-01
    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deciphering metabolic dysfunction‐associated steatotic liver disease: insights from predictive modeling and clustering analysis2024

    • Author(s)
      Mori Kazuma、Akiyama Yukinori、Tanaka Marenao、Sato Tatsuya、Endo Keisuke、Hosaka Itaru、Hanawa Nagisa、Sakamoto Naoya、Furuhashi Masato
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: Apr 17 Issue: 7 Pages: 1382-1393

    • DOI

      10.1111/jgh.16552

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive modeling for the development of diabetes mellitus using key factors in various machine learning approaches2024

    • Author(s)
      Tanaka Marenao、Akiyama Yukinori、Mori Kazuma、Hosaka Itaru、Kato Kenichi、Endo Keisuke、Ogawa Toshifumi、Sato Tatsuya、Suzuki Toru、Yano Toshiyuki、Ohnishi Hirofumi、Hanawa Nagisa、Furuhashi Masato
    • Journal Title

      Diabetes Epidemiology and Management

      Volume: 13 Pages: 100191-100191

    • DOI

      10.1016/j.deman.2023.100191

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Phenotypes in Subcutaneous Fat and Perivascular Adipose Tissue Surrounding the Saphenous Vein in Coronary Artery Bypass Grafting2023

    • Author(s)
      Mikami Takuma、Furuhashi Masato、Numaguchi Ryosuke、Hosaka Itaru、Sakai Akiko、Tanaka Marenao、Ito Toshiro、Maeda Toshiyuki、Sakurada Taku、Muraki Satoshi、Yanase Yousuke、Sato Hiroshi、Fukada Joji、Tamiya Yukihiko、Iba Yutaka、Kawaharada Nobuyoshi
    • Journal Title

      Circulation Journal

      Volume: 87 Issue: 6 Pages: 791-798

    • DOI

      10.1253/circj.CJ-22-0740

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2023-05-25
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Coexistence of Metabolic Dysfunction‐Associated Fatty Liver Disease and Chronic Kidney Disease Is a More Potent Risk Factor for Ischemic Heart Disease2023

    • Author(s)
      Miyamori Daisuke、Tanaka Marenao、Sato Tatsuya、Endo Keisuke、Mori Kazuma、Mikami Takuma、Hosaka Itaru、Hanawa Nagisa、Ohnishi Hirofumi、Furuhashi Masato
    • Journal Title

      Journal of the American Heart Association

      Volume: 12 Issue: 14

    • DOI

      10.1161/jaha.123.030269

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An increase in calculated small dense low-density lipoprotein cholesterol predicts new onset of hypertension in a Japanese cohort2023

    • Author(s)
      Tanaka Marenao、Sato Tatsuya、Endo Keisuke、Inyaku Masafumi、Mori Kazuma、Hosaka Itaru、Mikami Takuma、Akiyama Yukinori、Ohnishi Hirofumi、Hanawa Nagisa、Furuhashi Masato
    • Journal Title

      Hypertension Research

      Volume: 46 Issue: 12 Pages: 2635-2645

    • DOI

      10.1038/s41440-023-01392-x

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] A high level of thyroid-stimulating hormone is a risk factor for the development of chronic kidney disease in men: a 10-year cohort study2023

    • Author(s)
      Endo Keisuke、Tanaka Marenao、Sato Tatsuya、Mori Kazuma、Hosaka Itaru、Mikami Takuma、Umetsu Araya、Akiyama Yukinori、Ohnishi Hirofumi、Hanawa Nagisa、Furuhashi Masato
    • Journal Title

      Hypertension Research

      Volume: 47 Issue: 3 Pages: 663-671

    • DOI

      10.1038/s41440-023-01453-1

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Circulating tumor necrosis factor-related biomarkers predict kidney function decline in Japanese patients with diabetes: An observational cohort study2023

    • Author(s)
      Murakoshi Maki、Kamei Nozomu、Suzuki Yusuke、Kubota Mitsunobu、Sanuki Michiyoshi、Tashiro Hirotaka、Iwasawa Takumi、Kato Kazunori、Tanaka Marenao、Furuhashi Masato、Gohda Tomohito
    • Journal Title

      Diabetes Research and Clinical Practice

      Volume: 206 Pages: 111017-111017

    • DOI

      10.1016/j.diabres.2023.111017

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolic dysfunction-associated fatty liver disease is associated with an increase in systolic blood pressure over time: linear mixed-effects model analyses2023

    • Author(s)
      Mori Kazuma、Tanaka Marenao、Hosaka Itaru、Mikami Takuma、Endo Keisuke、Hanawa Nagisa、Ohnishi Hirofumi、Furuhashi Masato
    • Journal Title

      Hypertension Research

      Volume: - Issue: 5 Pages: 1110-1121

    • DOI

      10.1038/s41440-023-01179-0

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glomerular expression and urinary excretion of fatty acid-binding protein 4 in IgA nephropathy2023

    • Author(s)
      Tanaka Marenao、Moniwa Norihito、Nogi Chieko、Kano Toshiki、Matsumoto Megumi、Sakai Akiko、Maeda Takuto、Takizawa Hideki、Ogawa Yayoi、Asanuma Katsuhiko、Suzuki Yusuke、Furuhashi Masato
    • Journal Title

      Journal of Nephrology

      Volume: 36 Issue: 2 Pages: 385-395

    • DOI

      10.1007/s40620-022-01551-2

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating PCSK7 Level is Independently Associated with Obesity, Triglycerides Level and Fatty Liver Index in a General Population without Medication2022

    • Author(s)
      Furuhashi Masato、Kataoka Yu、Nishikawa Ryo、Koyama Masayuki、Sakai Akiko、Higashiura Yukimura、Tanaka Marenao、Saitoh Shigeyuki、Shimamoto Kazuaki、Ohnishi Hirofumi
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 29 Issue: 9 Pages: 1275-1284

    • DOI

      10.5551/jat.63159

    • NAID

      130008091658

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2022-09-01
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased LDL cholesterol level is associated with deterioration of renal function in males2022

    • Author(s)
      Osanami Arata、Tanaka Marenao、Furuhashi Masato、Ohnishi Hirofumi、Hanawa Nagisa、Yamashita Tomohisa、Moniwa Norihito、Miura Tetsuji
    • Journal Title

      Clinical Kidney Journal

      Volume: - Issue: 10 Pages: 1888-1895

    • DOI

      10.1093/ckj/sfac111

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High fibrosis-4 (FIB-4) index predicts new onset of ischemic heart disease during a 10-year period in a general population2022

    • Author(s)
      Higashiura Yukimura、Tanaka Marenao、Mori Kazuma、Mikami Takuma、Hosaka Itaru、Ohnishi Hirofumi、Hanawa Nagisa、Furuhashi Masato
    • Journal Title

      European Heart Journal Open

      Volume: - Issue: 3

    • DOI

      10.1093/ehjopen/oeac030

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced nuclear localization of phosphorylated MLKL predicts adverse events in patients with dilated cardiomyopathy2022

    • Author(s)
      Fujita Y, Yano T, Kanamori H, Nagahara D, Muranaka A, Kouzu H, Mochizuki A, Koyama M, Nagano N, Fujito T, Nishikawa R, Kamiyama N, Tanaka M, Kuno A, Tanno M, Miura T
    • Journal Title

      ESC Heart Failure

      Volume: 9 Issue: 5 Pages: 3435-3451

    • DOI

      10.1002/ehf2.14059

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Marked bilateral global persistent CT nephrogram 48?h after percutaneous coronary intervention with contrast-induced nephropathy requiring transient hemodialysis with severe cardiac dysfunction2022

    • Author(s)
      Moniwa Norihito、Kimura Ayumu、Nishikawa Ryo、Tanaka Marenao
    • Journal Title

      CEN Case Reports

      Volume: 12 Issue: 1 Pages: 1-6

    • DOI

      10.1007/s13730-022-00713-2

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolic dysfunction?associated fatty liver disease predicts new onset of chronic kidney disease better than fatty liver or nonalcoholic fatty liver disease2022

    • Author(s)
      Tanaka Marenao、Mori Kazuma、Takahashi Satoko、Higashiura Yukimura、Ohnishi Hirofumi、Hanawa Nagisa、Furuhashi Masato
    • Journal Title

      Nephrology Dialysis Transplantation

      Volume: 38 Issue: 3 Pages: 700-711

    • DOI

      10.1093/ndt/gfac188

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical and pathological characteristics of patients with acute kidney injury in Japan in whom kidney biopsy was performed: a cross-sectional analysis of the Japan Renal Biopsy Registry (J?RBR)2022

    • Author(s)
      Moniwa Norihito、Tanaka Marenao、Sato Hiroshi、Shimizu Akira、Sugiyama Hitoshi、Yokoyama Hitoshi、Tsuruya Kazuhiko、Hashiguchi Akinori、the Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 26 Issue: 10 Pages: 963-973

    • DOI

      10.1007/s10157-022-02236-7

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High fatty liver index is an independent predictor of ischemic heart disease during a 10‐year period in a Japanese population2022

    • Author(s)
      Mori Kazuma、Tanaka Marenao、Higashiura Yukimura、Hanawa Nagisa、Ohnishi Hirofumi、Furuhashi Masato
    • Journal Title

      Hepatology Research

      Volume: 52 Issue: 8 Pages: 687-698

    • DOI

      10.1111/hepr.13790

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reply to the comments of Naharci on “Circulating level of fatty acid‐binding protein?4 is an independent predictor of metabolic dysfunction‐associated fatty liver disease in middle‐aged and elderly individuals”2022

    • Author(s)
      Tanaka Marenao、Furuhashi Masato
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 13 Issue: 5 Pages: 928-929

    • DOI

      10.1111/jdi.13808

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasma Tsukushi Concentration Is Associated with High Levels of Insulin and FGF21 and Low Level of Total Cholesterol in a General Population without Medication2022

    • Author(s)
      Furuhashi Masato、Higashiura Yukimura、Sakai Akiko、Koyama Masayuki、Tanaka Marenao、Saitoh Shigeyuki、Shimamoto Kazuaki、Ohnishi Hirofumi
    • Journal Title

      Metabolites

      Volume: 12 Issue: 3 Pages: 237-237

    • DOI

      10.3390/metabo12030237

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diabetes modulation of the myocardial infarction-acute kidney injury axis2022

    • Author(s)
      Miura Tetsuji、Kuno Atsushi、Tanaka Marenao
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: 322 Issue: 3 Pages: H394-H405

    • DOI

      10.1152/ajpheart.00639.2021

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of membranous nephropathy secondary to asymptomatic Graves' disease2022

    • Author(s)
      Moniwa N, Shioya Y, Gocho Y, Takahashi S, Tanaka M, Furuhashi M, Kuroda S, Hama T, Shima Y, Ogawa Y, Miura T.
    • Journal Title

      CEN Case Rep.

      Volume: - Issue: 3 Pages: 309-313

    • DOI

      10.1007/s13730-021-00672-0

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating level of fatty acid‐binding protein 4 is an independent predictor of metabolic dysfunction‐associated fatty liver disease in middle‐aged and elderly individuals2022

    • Author(s)
      Tanaka Marenao、Takahashi Satoko、Higashiura Yukimura、Sakai Akiko、Koyama Masayuki、Saitoh Shigeyuki、Shimamoto Kazuaki、Ohnishi Hirofumi、Furuhashi Masato
    • Journal Title

      Journal of Diabetes Investigation

      Volume: Dec 9 Issue: 5 Pages: 878-888

    • DOI

      10.1111/jdi.13735

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prediction and validation of nonalcoholic fatty liver disease by fatty liver index in a Japanese population2022

    • Author(s)
      Takahashi Satoko、Tanaka Marenao、Higashiura Yukimura、Mori Kazuma、Hanawa Nagisa、Ohnishi Hirofumi、Furuhashi Masato
    • Journal Title

      Endocrine Journal

      Volume: 69 Issue: 4 Pages: 463-471

    • DOI

      10.1507/endocrj.EJ21-0563

    • NAID

      130008118746

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Fatty Liver Indexを用いて高血圧発症を予測する機械学習モデルの構築2023

    • Author(s)
      田中希尚、秋山幸功、佐藤亮太、保坂到、三上拓真、遠藤圭佑、梅津新矢、森和真、小川俊史、佐藤達也、塙なぎさ、古橋眞人
    • Organizer
      第 45 回日本高血圧学会
    • Related Report
      2023 Research-status Report
  • [Presentation] 代謝異常関連脂肪肝疾患(MAFLD)は収縮期血圧の経時的な上昇と関連する: 線形混合効果モデルを用いた解析2023

    • Author(s)
      遠藤圭祐、 森和真、 田中希尚、佐藤達也、大西浩文、塙なぎさ、古橋眞人
    • Organizer
      第66回日本糖尿病学会学術集会
    • Related Report
      2023 Research-status Report
  • [Presentation] Thyroid-stimulating hormone高値は男性の新規CKD発症と関連する2023

    • Author(s)
      遠藤圭佑、田中希尚、佐藤達也、塙なぎさ、大西浩文、古橋眞人
    • Organizer
      第120回日本内科学会総会
    • Related Report
      2023 Research-status Report
  • [Presentation] IgA腎症での糸球体障害における脂肪酸結合蛋白4 (FABP4)の関与についての検討2023

    • Author(s)
      田中希尚、茂庭仁人、禾千絵子、淺沼克彦、鈴木祐介、古橋眞人
    • Organizer
      第66回日本腎臓学会学術総会
    • Related Report
      2023 Research-status Report
  • [Presentation] FSGS NOS variantの腎組織像を呈した妊娠高血圧腎症によるネフローゼ症候群の一例2023

    • Author(s)
      柴田 智、田中 希尚、大野 紘平、伊藤 孝仁、堀田 寛之、松本 倫明、三木 隆幸、辻 隆裕、大岩 均
    • Organizer
      第53回日本腎臓学会西部学術大会
    • Related Report
      2023 Research-status Report
  • [Presentation] 抗リン脂質抗体症候群腎症の臨床病理学的検討:日本腎病理協会による希少腎疾患の 多施設共同研究2023

    • Author(s)
      岩崎 沙理、 小川 弥生、名和田 彩、辻 隆裕、江原 孝史、田中 希尚、難波倫子、大橋 温、須藤 真則、今井 直史、小泉 賢洋、清水 章
    • Organizer
      第66回日本腎臓学会学術総会
    • Related Report
      2023 Research-status Report
  • [Presentation] 大規模健診データを基にした眼圧と高血圧の相関の検討2023

    • Author(s)
      梅津新矢、田中希尚、渡部恵、塙なぎさ、古橋眞人、大黒浩
    • Organizer
      第77回日本臨床眼科学会
    • Related Report
      2023 Research-status Report
  • [Presentation] Metabolic dysfunction-associated fatty liver disease predicts new onset of chronic kidney disease better than does fatty liver or nonalcoholic fatty liver disease.2022

    • Author(s)
      Marenao Tanaka, Kazuma Mori, Satoko Takahashi, Yukimura Higashiura, Hirofumi Ohnishi, Nagisa Hanawa, Masato Furuhashi
    • Organizer
      The 29th Scientific Meeting of the International Society of Hypertension
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 尿酸とCOVID-19の原因ウイルスSARS-CoV-2の宿主側受容体ACE2との関連についての検討2022

    • Author(s)
      古橋眞人,酒井晶子,田中希尚,東浦幸村,森 和真,小山雅之,大西浩文,齋藤重幸,島本和明
    • Organizer
      第55回 日本痛風・尿酸核酸学会 総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 血清尿酸値は女性において収縮期血圧の経時的な上昇と関連する: 線形混合効果モデルでの解析2022

    • Author(s)
      森 和真,田中希尚,東浦幸村,小山雅之,塙 なぎさ,大西浩文,古橋眞人
    • Organizer
      第55回 日本痛風・尿酸核酸学会 総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 日本人におけるFatty liver indexによるnonalcoholic fatty liver disease診断のカットオフ値の検討2022

    • Author(s)
      高橋聖子,田中希尚,東浦幸村,塙 なぎさ,大西浩文,古橋眞人
    • Organizer
      第119回 日本内科学会 総会
    • Related Report
      2022 Research-status Report
  • [Presentation] Fibrosis-4 (FIB-4) Indexは新規の虚血性心疾患発症の独立した予測因子である2022

    • Author(s)
      第65回 日本糖尿病学会 年次学術総会
    • Organizer
      第65回 日本糖尿病学会 年次学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 代謝異常関連脂肪肝疾患(MAFLD)とCKD発症リスクの関連についての検討2022

    • Author(s)
      田中希尚,高橋聖子,森 和真,東浦幸村,大西浩文,塙 なぎさ,古橋眞人
    • Organizer
      第65回 日本腎臓学会 学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] ガイドニードルを用いた超音波ガイド下腎生検は手技時間を短縮する2022

    • Author(s)
      小松弘明,山下智久,長南新太,赤澤史子,遠藤康太,津川 舜,宮森大輔,木村 歩,安部功記,高橋聖子,後町 結,佐藤達也,小山雅之,田中希尚,矢野俊之,茂庭仁人
    • Organizer
      第65回 日本腎臓学会 学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] トルバプタンと生理食塩水による造影剤腎症予防効果2022

    • Author(s)
      木村 歩,茂庭仁人,柴田 智,田中希尚
    • Organizer
      第65回 日本腎臓学会 学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] Fatty liver index (FLI) の高値は虚血性心疾患の独立した予測因子である2022

    • Author(s)
      森 和真,田中希尚,東浦幸村,塙 なぎさ,大西浩文,古橋眞人
    • Organizer
      第44回 日本高血圧学会 学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 扁桃摘出とステロイド内服にて完全寛解に至ったIgA血管炎の一例2022

    • Author(s)
      田中希尚,長南新太,山下智久,古橋眞人,松本倫明,大野紘平,伊藤孝仁,堀田寛之,加藤伸郎,三木隆幸,大岩 均,辻 隆裕
    • Organizer
      第52回 日本腎臓学会 東部学術大会
    • Related Report
      2022 Research-status Report
  • [Remarks] 札幌医科大学循環器・腎臓・代謝内分泌内科学講座 業績

    • URL

      https://web.sapmed.ac.jp/im2/outline/ollngo00000000fj.html

    • Related Report
      2022 Research-status Report

URL: 

Published: 2022-04-19   Modified: 2024-12-25  

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