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Effects of defective glucose metabolism in osteocytes on osteoclastogenesis and orthodontic tooth movement

Research Project

Project/Area Number 22K10236
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57070:Developmental dentistry-related
Research InstitutionTohoku University

Principal Investigator

北浦 英樹  東北大学, 歯学研究科, 准教授 (60295087)

Co-Investigator(Kenkyū-buntansha) 溝口 到  東北大学, 歯学研究科, 教授 (20200032)
野口 隆弘  東北大学, 大学病院, 助教 (20907430)
大堀 文俊  東北大学, 歯学研究科, 助教 (90937129)
Project Period (FY) 2022-04-01 – 2025-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2024: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords骨細胞 / 糖代謝 / 矯正学的歯の移動 / 破骨細胞 / マウス / 骨吸収
Outline of Research at the Start

近年、糖尿病、高血圧、肥満などの生活習慣病と骨代謝の関係が注目を浴びている。そこで本研究では糖代謝不全骨細胞の破骨細胞誘導能への影響を解明するために、糖代謝不全骨細胞をin vitroで作成し、さらに細胞内糖輸送に関連するグルコーストランスポーターであるGLUT1をコードするSlc2a1をloxPで挟んだSlc2a1tm1.1Stma マウスにDmp1-Creマウスを交配し骨細胞特異的にGLUT1遺伝子欠損することで骨細胞特異的糖代謝不全マウスを作成し、破骨細胞形成および骨吸収を解析し、骨細胞糖代謝の骨代謝および糖尿病へ関与、さらに矯正学的歯の移動への影響を明らかにする。

Outline of Annual Research Achievements

近年、糖尿病、高血圧、肥満などの生活習慣病が増加している。また、矯正歯科領域においても様々な生活習慣病を有する患者が増加している。この中で糖尿病では、破骨細胞の増加により骨密度が減少し骨折のリスクが高くなることが大きな問題となっている。また、歯周病によって、歯槽骨吸収が増加することも糖尿病の大きな問題である。矯正歯科領域でも骨を吸収して歯が移動することから糖代謝は、重要な関係性があると考えている。近年、骨細胞が破骨細胞形成に重要な役割を果たしていることがわかった(Nakashima et al. Nat Med, 2011)。そこで本研究では糖代謝不全骨細胞の破骨細胞誘導能への影響を解明するために、糖代謝不全骨細胞をin vitroで作成し、さらに細胞内糖輸送に関連するグルコーストランスポーターであるGLUT1をコードするSlc2a1をloxPで挟んだSlc2a1tm1.1Stma マウスにDmp1-Creマウスを交配し骨細胞特異的にGLUT1遺伝子欠損することで骨細胞特異的糖代謝不全マウスを作成し、破骨細胞形成および骨吸収を解析し、骨細胞糖代謝の骨代謝および糖尿病へ関与、さらに矯正学的歯の移動への影響を明らかにすることが目的である。このマウスを作成するためにSlc2a1をloxPで挟んだSlc2a1tm1.1Stma マウスの凍結胚よりマウスを作成し、クリーン化を行い、繁殖を開始した。現在、骨細胞においてfloxed配列を切除するDmp1-Creマウスの凍結胚よりマウスを作成し、クリーン化が終わり繁殖を開始した。現在、Slc2a1tm1.1StmaマウスとDmp1-Creマウスを交配しGLUT1骨細胞特異的欠損マウスを作成し、繁殖を開始した。現在、解析のためにさらに個体数を増加させるため、マウスの繁殖を継続している。個体数が確保できたら、解析する予定である。

Current Status of Research Progress
Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

GLUT1をコードするSlc2a1をloxPで挟んだSlc2a1tm1.1Stma マウスおよびDmp1-Creマウスの到着が遅れたため、目的の骨細胞特異的にGLUT1遺伝子欠損することで骨細胞特異的糖代謝不全マウスの作成が遅れたため。

Strategy for Future Research Activity

グルコーストランスポーターであるGLUT1をコードするSlc2a1をloxPで挟んだSlc2a1tm1.1Stma マウスにDmp1-Creマウスを交配し骨細胞特異的にGLUT1遺伝子欠損することで骨細胞特異的糖代謝不全マウス(Glut1ocy-/-)ができた。このマウスの繁殖が進みマウスの数が必要数集まり次第Glut1ocy-/-マウスモデルの特性を検討する。GLUT1の発現を5-6日齢の野生型(Wild tpe以下WTとする)およびGlut1ocy-/-マウスの頭蓋骨にコラゲナーゼおよびEDTAを用いて段階的な酵素処理を行い、得られたFraction3-5の骨細胞リッチフラクションを回収する。骨細胞リッチフラクションにおけるGLUT1のmRNAレベルをreal-time RT-PCRで確認する。また、タンパク質レベルでは単離した骨細胞のウエスタンブロットを用いて確認する。 Glut1ocy-/-マウスとWTの骨細胞リッチフラクションの細胞をグルコースアッセイキットを用いてグルコースの取り込み率を比較する。モデルマウスの表現型を調べるGlut1ocy-/-マウスとWTの骨体積/海綿体体積、骨細胞数、骨芽細胞数、破骨細胞数/骨面積、皮質骨厚、海綿体骨厚等を組織形態学的な骨分析を用いて調べ比較する。Glut1ocy-/-マウスとWT から得た骨細胞および骨芽細胞の発現する分子をreal-time RT-PCRで調べる。オステオカルシン、RANKL/OPG、スクレロスチン、Dmp1、 FGF23、PHEXなど、骨のターンオーバー状態と骨のミネラルホメオスタシスを反映する分子を調べる。 Glut1ocy-/-とWTマウスのTNF-αやIL-6などの全身の炎症マーカーも測定する。

Report

(2 results)
  • 2023 Research-status Report
  • 2022 Research-status Report
  • Research Products

    (59 results)

All 2024 2023 2022

All Journal Article (15 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 15 results,  Open Access: 13 results) Presentation (43 results) (of which Int'l Joint Research: 28 results,  Invited: 9 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] (D-Ala2)GIP Inhibits Inflammatory Bone Resorption by Suppressing TNF-α and RANKL Expression and Directly Impeding Osteoclast Formation2024

    • Author(s)
      Lin Angyi、Kitaura Hideki、Ohori Fumitoshi、Noguchi Takahiro、Marahleh Aseel、Ma Jinghan、Ren Jiayi、Miura Mariko、Fan Ziqiu、Narita Kohei、Mizoguchi Itaru
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 25 Issue: 5 Pages: 2555-2555

    • DOI

      10.3390/ijms25052555

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generating Bone Marrow Chimeric Mouse Using GPR120 Deficient Mouse for the Study of DHA Inhibitory Effect on Osteoclast Formation and Bone Resorption2023

    • Author(s)
      Ma Jinghan、Kitaura Hideki、Ohori Fumitoshi、Noguchi Takahiro、Marahleh Aseel、Kinjo Ria、Kanou Kayoko、Ren Jiayi、Miura Mariko、Narita Kohei、Mizoguchi Itaru
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 23 Pages: 17000-17000

    • DOI

      10.3390/ijms242317000

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Azilsartan inhibits inflammation-triggered bone resorption and osteoclastogenesis in vivo via suppression of TNF-α expression in macrophages2023

    • Author(s)
      Fan Ziqiu、Kitaura Hideki、Ren Jiayi、Ohori Fumitoshi、Noguchi Takahiro、Marahleh Aseel、Ma Jinghan、Kanou Kayoko、Miura Mariko、Narita Kohei、Lin Angyi、Mizoguchi Itaru
    • Journal Title

      Frontiers in Endocrinology

      Volume: 14 Pages: 1207502-1207502

    • DOI

      10.3389/fendo.2023.1207502

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Osteocyte and its Osteoclastogenic Potential2023

    • Author(s)
      Aseel Marahleh
    • Journal Title

      Frontiers in Endocrinology

      Volume: 14 Pages: 1121727-1121727

    • DOI

      10.3389/fendo.2023.1121727

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fermented Rice Bran Supplementation Inhibits LPS-Induced Osteoclast Formation and Bone Resorption in Mice2023

    • Author(s)
      Noguchi Takahiro、Kitaura Hideki、Marahleh Aseel、Agista Afifah Zahra、Ohsaki Yusuke、Shirakawa Hitoshi、Mizoguchi Itaru
    • Journal Title

      Nutrients

      Volume: 15 Issue: 13 Pages: 3044-3044

    • DOI

      10.3390/nu15133044

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Docosahexaenoic acid inhibits TNF-α-induced osteoclast formation and orthodontic tooth movement through GPR1202023

    • Author(s)
      Jinghan Ma, Hideki Kitaura, Saika Ogawa, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Kayoko Kanou, Akiko Kishikawa, Atsuhiko Ichimura, Itaru Mizoguchi
    • Journal Title

      Front Immunol.

      Volume: eCollection 2022. Pages: 929690-929690

    • DOI

      10.3389/fimmu.2022.929690

    • Related Report
      2023 Research-status Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-dimensional morphologic analysis of the maxillary alveolar bone after anterior tooth retraction with temporary anchorage devices2023

    • Author(s)
      Ito Arata、Mayama Atsushi、Oyanagi Toshihito、Ogura Hiroki、Seiryu Masahiro、Fukunaga Tomohiro、Kitaura Hideki、Mizoguchi Itaru
    • Journal Title

      The Angle Orthodontist

      Volume: 93 Issue: 6 Pages: 667-674

    • DOI

      10.2319/120122-827.1

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD40-CD40 ligand interaction between periodontal ligament cells and cementoblasts enhances periodontal tissue remodeling in response to mechanical stress.2023

    • Author(s)
      Yamamoto Y, Fujihara C, Nantakeeratipat T, Matsumoto M, Noguchi T, Kitagawa M, Yamada S, Takata T, Kitaura H, Murakami S.
    • Journal Title

      J Periodontal Res.

      Volume: 58(6) Issue: 6 Pages: 1261-1271

    • DOI

      10.1111/jre.13182

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Craniofacial Characteristics and Orthodontic Treatment of Diamond Blackfan Syndrome: Two Case Reports2023

    • Author(s)
      Sasaki Satoshi、Kitaura Hideki、Goto Maki、Yoshida Michiko、Mizoguchi Itaru
    • Journal Title

      The Cleft Palate Craniofacial Journal

      Volume: 60 Issue: 1 Pages: 98-104

    • DOI

      10.1177/10556656211053774

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Titanium nanotopography induces osteocyte lacunar-canalicular networks to strengthen osseointegration2022

    • Author(s)
      He Xindie、Yamada Masahiro、Watanabe Jun、Tiskratok Watcharaphol、Ishibashi Minoru、Kitaura Hideki、Mizoguchi Itaru、Egusa Hiroshi
    • Journal Title

      Acta Biomaterialia

      Volume: 151 Pages: 613-627

    • DOI

      10.1016/j.actbio.2022.08.023

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of anti-mouse RANKL antibody on orthodontic tooth movement in mice2022

    • Author(s)
      Masako Yoshimatsu, Hideki Kitaura, Yukiko Morita, Takuya Nakamura, Takashi Ukai
    • Journal Title

      J Dent Sci

      Volume: - Issue: 3 Pages: 1087-1095

    • DOI

      10.1016/j.jds.2022.02.007

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhancement of orthodontic tooth movement and root resorption in ovariectomized mice2022

    • Author(s)
      Nara Yasuhiko、Kitaura Hideki、Marahleh Aseel、Ohori Fumitoshi、Noguchi Takahiro、Pramusita Adya、Kinjo Ria、Ma Jinghan、Kanou Kayoko、Mizoguchi Itaru
    • Journal Title

      Journal of Dental Sciences

      Volume: 17 Issue: 2 Pages: 984-990

    • DOI

      10.1016/j.jds.2021.11.009

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Salt-Sensitive Hypertension Induces Osteoclastogenesis and Bone Resorption via Upregulation of Angiotensin II Type 1 Receptor Expression in Osteoblasts2022

    • Author(s)
      Adya Pramusita, Hideki Kitaura, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Ria Kinjo, Jinghan Ma, Kayoko Kanou, Yukinori Tanaka and Itaru Mizoguchi
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 10 Pages: 816764-816764

    • DOI

      10.3389/fcell.2022.816764

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Micro-Osteoperforations Induce TNF-α Expression and Accelerate Orthodontic Tooth Movement via TNF-α-Responsive Stromal Cells2022

    • Author(s)
      Kinjo Ria、Kitaura Hideki、Ogawa Saika、Ohori Fumitoshi、Noguchi Takahiro、Marahleh Aseel、Nara Yasuhiko、Pramusita Adya、Ma Jinghan、Kanou Kayoko、Mizoguchi Itaru
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 6 Pages: 2968-2968

    • DOI

      10.3390/ijms23062968

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of Coating Loss from Coated Stainless Steel Orthodontic Wire2022

    • Author(s)
      Ito Arata、Kitaura Hideki、Noguchi Takahiro、Ohori Fumitoshi、Mizoguchi Itaru
    • Journal Title

      Applied Sciences

      Volume: 12 Issue: 19 Pages: 9497-9497

    • DOI

      10.3390/app12199497

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 塩分による高血圧が骨粗鬆症を誘発するメカニズムの解明2023

    • Author(s)
      北浦英樹
    • Organizer
      高血圧フォーラム2023
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] High Glucose induces alternative splicing changes in primary osteocytes with minimal transcriptional alterations.2023

    • Author(s)
      Marahleh A, Rashad S, Kitaura H, Ren J, Ohori F, Noguchi T, Mizoguchi I.
    • Organizer
      Cell Bio
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Involvement of osteocyte necroptosis on osteoclastogenesis during orthodontic tooth movement2023

    • Author(s)
      hori F, Kitaura H, Noguchi T, Marahleh A, Ma J, Kanou K, Miura M, Ren J, Ren J, Narita K, Mizoguchi I.
    • Organizer
      The 71st Annual Meeting of Japanese Association for Dental Reaearch
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] The transcriptomic landscape of hyperglycemic osteocytes.2023

    • Author(s)
      Marahleh A, Kitaura H, Rashad S, Ren J, Ohori F, Noguchi T, Mizoguchi I.
    • Organizer
      The 82nd Annual Meeting of the Japanese Orthodontic Society.
    • Related Report
      2023 Research-status Report
  • [Presentation] Analysis of DHA effects on osteoclastogenesis through GPR120 in a bone marrow chimeric mouse model.2023

    • Author(s)
      Ma J, Kitaura H, Ohori F, Noguchi T, Marahleh A, Kinjo R, Kanou K, Mizoguchi I.
    • Organizer
      The 82nd Annual Meeting of the Japanese Orthodontic Society
    • Related Report
      2023 Research-status Report
  • [Presentation] Azilsartan attenuates LPS-induced osteoclastogenesis and bone resorption via inhibition of TNF-α expression in macrophages.2023

    • Author(s)
      Fan Z, Kitaura H, Ren J, Ohori F, Noguchi T, Marahleh A, Ma J, Kanou K, Miura M, Narita K, Lin A, Mizoguchi I.
    • Organizer
      The 82nd Annual Meeting of the Japanese Orthodontic Society
    • Related Report
      2023 Research-status Report
  • [Presentation] Hyperglycemia induces extensive alternative splicing changes in osteocytes with minimal transcriptional alterations.2023

    • Author(s)
      Marahleh A, Rashad S, Kitaura H, Ren J, Ohori F, Noguchi T, Mizoguchi I.
    • Organizer
      American Society for Bone and Mineral Research 2023 Annual Meeting
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of DAMPs released from osteocyte necroptosis on osteoclastogenesis.2023

    • Author(s)
      Ohori F, Kitaura H, Noguchi T, Marahleh A, Ma J, Kanou K, Miura M, Ren J, Narita K, Ren J, Mizoguchi I.
    • Organizer
      American Society for Bone and Mineral Research 2023 Annual Meeting
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Docosahexaenoic acid inhibits TNF-α-induced osteoclast formation and bone resorption through GPR120.2023

    • Author(s)
      Ma J, Kitaura H, Ohori F, Noguchi T, Marahleh A, Kinjo R, Kanou K, Mizoguchi I.
    • Organizer
      American Society for Bone and Mineral Research 2023 Annual Meeting.
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Azilsartan inhibits inflammation-triggered bone resorption and osteoclastogenesis in vivo via suppression of TNF-α expression in macrophages.2023

    • Author(s)
      Fan Z, Kitaura H, Ren J, Ohori F, Noguchi T, Marahleh A, Ma J, Kanou K, Miura M, Narita K, Lin A, Mizoguchi I.
    • Organizer
      American Society for Bone and Mineral Research 2023 Annual Meeting.
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Angiotensin-(1-7) attenuated LPS-induced osteoclastogenesis and bone resorption via inhibiting the activation of MAPK pathway in macrophages.2023

    • Author(s)
      Ren J, Kitaura H, Noguchi T, Ohori F, Marahleh A, Ma J, Kanou K, Miura M, Narita K, Mizoguchi I.
    • Organizer
      American Society for Bone and Mineral Research 2023 Annual Meeting
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] RNA sequencing analysis of osteoclast related genes in osteocyte-like cell line cultured in hypoxic environment.2023

    • Author(s)
      Narita K, Kitaura H, Ohori F, Noguchi T, Marahleh A, Ma J, Kanou K, Miura M, Ren J, Mizoguchi I.
    • Organizer
      American Society for Bone and Mineral Research 2023 Annual Meeting.
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Hyperglycemia induces extensive alternative splicing changes in osteocytes with minimal transcriptional alterations.2023

    • Author(s)
      Marahleh A, Rashad S, Kitaura H, Ren J, Ohori F, Noguchi T, Mizoguchi I.
    • Organizer
      ASBMR Pre-Meeting Symposium on Osteocytes in Bone Health and Disease and as Therapeutic Target Cells.
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of DAMPs released from osteocyte necroptosis on osteoclastogenesis.2023

    • Author(s)
      Ohori F, Kitaura H, Noguchi T, Marahleh A, Ma J, Kanou K, Miura M, Ren J, Narita K, Ren J, Mizoguchi I.
    • Organizer
      ASBMR Pre-Meeting Symposium on Osteocytes in Bone Health and Disease and as Therapeutic Target Cells.
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Azilsartan inhibits inflammation-triggered bone resorption and osteoclastogenesis in vivo via suppression of TNF-α expression in macrophages.2023

    • Author(s)
      Fan Z, Kitaura H, Ren J, Ohori F, Noguchi T, Marahleh A, Ma J, Kanou K, Miura M, Narita K, Lin A, Mizoguchi I.
    • Organizer
      ASBMR Pre-Meeting Symposium on Osteocytes in Bone Health and Disease and as Therapeutic Target Cells.
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] RNA sequencing analysis of osteoclast related genes in osteocyte-like cell line cultured in hypoxic environment.2023

    • Author(s)
      Narita K, Kitaura H, Ohori F, Noguchi T, Marahleh A, Ma J, Kanou K, Miura M, Ren J, Mizoguchi I.
    • Organizer
      ASBMR Pre-Meeting Symposium on Osteocytes in Bone Health and Disease and as Therapeutic Target Cells.
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of long-acting glucose-dependent insulinotropic polypeptide analogue on inflammation-induced osteoclast formation and bone resorption.2023

    • Author(s)
      Lin A, Kitaura H, Ren J, Marahleh A, Ohori F, Noguchi T, Ma J, Kanou K, Miura M, Narita K, Lin A, Fan Z, Mizoguchi I.
    • Organizer
      The 18th International Workshop on Biomaterials in Interface Science
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Azilsartan Suppresses LPS-Induced Bone Resorption and Osteoclast Formation in vivo by Inhibiting TNF-α Expression in Macrophages.2023

    • Author(s)
      Fan Z, Kitaura H, Ren J, Ohori F, Noguchi T, Marahleh A, Ma J, Kanou K, Miura M, Narita K, Lin A, Mizoguchi I.
    • Organizer
      The 18th International Workshop on Biomaterials in Interface Science
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Angiotensin-(1-7) alleviated LPS-induced osteoclastogenesis and bone resorption via dampening of MAPK pathway in macrophages.2023

    • Author(s)
      Ren J, Kitaura H, Noguchi T, Ohori F, Marahleh A, Ma J, Kanou K, Miura M, Narita K, Mizoguchi I.
    • Organizer
      The 80th Tohoku Daigaku Shigakukai
    • Related Report
      2023 Research-status Report
  • [Presentation] Docosahexaenoic acid suppresses osteoclast formation and orthodontic tooth movement via GPR120.2023

    • Author(s)
      Ma J, Kitaura H, Ohori F, Noguchi T, Marahleh A, Kinjo R, Kanou K, Mizoguchi I.
    • Organizer
      CA+inD International Symposium 2023
    • Related Report
      2023 Research-status Report 2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Study of expression osteoclast differentiation-related genes in osteocytes by TNF-α stimulation using RNA sequencing.2023

    • Author(s)
      Miura M, Kitaura H, Ohori F, Noguchi T, Marahleh A, Kinjo R, Ma J, Kano K, Mizoguchi I.
    • Organizer
      CA+inD International Symposium 2023
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of mechanism of accelerated tooth movement by micro-osteoperforations.2023

    • Author(s)
      Kinjo R, Kitaura H, Ohori F, Noguchi T, Marahleh A, Ma J, Kano K, Mizoguchi I.
    • Organizer
      CA+inD International Symposium 2023
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヒストンメチル化酵素SET7/9が破骨細胞分化に及ぼす影響について2023

    • Author(s)
      野口隆弘、北浦英樹、大堀文俊、Marahleh Aseel、Ma Jinghan、加納佳与子、三浦まり子、成田昂平、溝口到
    • Organizer
      第82回日本矯正歯科学会学術大会
    • Related Report
      2023 Research-status Report
  • [Presentation] 老齢マウスにおける矯正学的歯の移動および破骨細胞形成の解析とそのメカニズムの解明2023

    • Author(s)
      加納佳与子、北浦英樹、野口隆弘、大堀文俊、Aseel Marahleh、金城里阿、Jinghan Ma、三浦まり子、成田昂平、溝口到
    • Organizer
      第82回日本矯正歯科学会学術大会
    • Related Report
      2023 Research-status Report
  • [Presentation] 低酸素環境における骨細胞様細胞(MLO-Y4細胞)のRNAシーケンス解析2023

    • Author(s)
      成田昂平、北浦英樹、大堀文俊、野口隆弘、マラーレ アジール、加納佳与子、マ ジンハン、三浦まり子、溝口到
    • Organizer
      第82回日本矯正歯科学会学術大会
    • Related Report
      2023 Research-status Report
  • [Presentation] Angiotensin-(1-7)はLPS刺激マクロファージにおけるTNF-αの発現を減少して破骨細胞形成と骨吸収を抑制する2023

    • Author(s)
      Ren Jiayi、北浦英樹、野口隆弘、大堀文俊、 Marahleh Aseel、 Ma Jinghan、加納佳代子、三浦まり子、成田昂平、溝口到
    • Organizer
      第82回日本矯正歯科学会学術大会
    • Related Report
      2023 Research-status Report
  • [Presentation] ネクロプトーシスした骨細胞が矯正学的歯の移動に伴う破骨細胞形成に与える影響2023

    • Author(s)
      大堀文俊、北浦英樹、野口隆弘、Marahleh Aseel、Ma Jinghan、加納佳与子、三浦まり子、成田昂平、溝口到
    • Organizer
      第82回日本矯正歯科学会学術大会
    • Related Report
      2023 Research-status Report
  • [Presentation] PTFE複合めっきによる歯科矯正用ワイヤーの摩擦特性への影響2023

    • Author(s)
      沼崎研人、北浦英樹、高橋正敏、高田雄京、溝口 到
    • Organizer
      令和5(2023)年度日本歯科理工学会北海道・東北地方会
    • Related Report
      2023 Research-status Report
  • [Presentation] Study of expression osteoclast differentiation-related genes in osteocytes by TNF-α stimulation using RNA sequencing2023

    • Author(s)
      Miura M, Kitaura H, Ohori F, Noguchi T, Marahleh A, Kinjo R, Ma J, Kano K, Mizoguchi I.
    • Organizer
      CA+inD International Symposium 2023
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of mechanism of accelerated tooth movement by micro-osteoperforations2023

    • Author(s)
      Kinjo R, Kitaura H, Ohori F, Noguchi T, Marahleh A, Ma J, Kano K, Mizoguchi I.
    • Organizer
      CA+inD International Symposium 2023
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Biological mechanism of orthodontic tooth movement.2022

    • Author(s)
      Kitaura, H.
    • Organizer
      WCSS UIP & CAMPUS ASIS PLUS Joint Symposium
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Accelerated orthodontic tooth movement by micro-osteoperforations.2022

    • Author(s)
      Kitaura, H.
    • Organizer
      2022 TU-HKU-FJMU International Symposium on Oral Health Sciences
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Introduction about Division of Orthodontics and Dentofacial Orthopedics,Tohoku University Graduate School of Dentistry.2022

    • Author(s)
      Kitaura, H.
    • Organizer
      UI-TU International Joint Symposium
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] RNA sequencing of expression osteoclast differentiation-related genes in osteocytes by TNF-α stimulation2022

    • Author(s)
      Miura M, Kitaura H, Ohori F, Noguchi T, Marahleh A, Kinjo R, Pramusita A, Jinghan M, Kano K, Mizoguchi I.
    • Organizer
      The 13th Asian Pacific Orthodontic Congress and The 55th Annual Scientific Congress of Korean Association of Orthodontists
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Mechanism of accelerated tooth movement by micro-osteoperforations2022

    • Author(s)
      Kinjo R, Kitaura H, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Pramusita A, Jingham M, Kanou K, Mizoguchi I.
    • Organizer
      The 13th Asian Pacific Orthodontic Congress and The 55th Annual Scientific Congress of Korean Association of Orthodontists
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Docosahexaenoic acid inhibits TNF-α-induced osteoclast formation and orthodontic tooth movement through GPR1202022

    • Author(s)
      Ma J, Kitaura H, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Pramusita A, Kinjo R, Kanou K, Kishikawa A, Ichimura A, Mizoguchi I.
    • Organizer
      The 81st Annual Meeting of the Japanese Orthodontic Society & The 9th Joint Symposium of the Japanese Orthodontic Society and Korean Association of Orthodontists
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of Angiotensin (1-7) on LPS-induced osteoclastogenesis2022

    • Author(s)
      Ren J, Kitaura H, Noguchi T, Ohori F, Marahleh A, Nara Y, Kinjo R, Kanou K, Ma J, Miura M, Mizoguchi I.
    • Organizer
      The 81st Annual Meeting of the Japanese Orthodontic Society & The 9th Joint Symposium of the Japanese Orthodontic Society and Korean Association of Orthodontists
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of Angiotensin (1-7) on LPS-induced osteoclastogenesis2022

    • Author(s)
      Ren J, Kitaura H, Noguchi T, Ohori F, Marahleh A, Nara Y, Kinjo R, Kano K, Ma J, Miura M, Mizoguchi I.
    • Organizer
      Interface Summer Seminar 2022, The 17th International Workshop on Biomaterials in Interface Science
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Docosahexaenoic acid inhibits TNF-α-induced osteoclast formation and orthodontic tooth movement through GPR1202022

    • Author(s)
      Ma J, Kitaura H, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Pramusita A, Kinjo R, Kano K, Kishikawa A, Ichimura A,Mizoguchi I.
    • Organizer
      The 79th Tohoku Daigaku Shigakukai
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 学会発表に必要な研究倫理申請の注意点2022

    • Author(s)
      北浦英樹
    • Organizer
      第16回東北矯正歯科学会秋期セミナー
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] Gli1陽性歯根膜細胞の実験的歯牙移動時における骨芽細胞分化機構2022

    • Author(s)
      関有里、建部廣明、北浦英樹、飯嶋雅弘、溝口 到、細矢明宏
    • Organizer
      第81回日本矯正歯科学会学術大会&第9回日韓ジョイントシンポジウム
    • Related Report
      2022 Research-status Report
  • [Presentation] TNF-αの骨細胞における破骨細胞分化関連遺伝子発現のRNAシーケンス2022

    • Author(s)
      三浦まり子、北浦英樹、大堀文俊、野口隆弘、マラーレ アジール、奈良靖彦、金城里阿、加納佳与子、マ ジンハン、溝口到
    • Organizer
      第81回日本矯正歯科学会学術大会&第9回日韓ジョイントシンポジウム
    • Related Report
      2022 Research-status Report
  • [Presentation] キメラマウスを用いた矯正学的歯の移動促進のマイクロオステオパーフォレーションの解析2022

    • Author(s)
      金城里阿、北浦英樹、大堀文俊、野口隆弘、マラーレ アジール、奈良靖彦、加納佳与子、マ ジンハン、三浦まり子、溝口到
    • Organizer
      第81回日本矯正歯科学会学術大会&第9回日韓ジョイントシンポジウム
    • Related Report
      2022 Research-status Report
  • [Patent(Industrial Property Rights)] 骨吸収の抑制剤2023

    • Inventor(s)
      白川仁、北浦英樹、野口隆弘、大崎雄介、溝口到
    • Industrial Property Rights Holder
      白川仁、北浦英樹、野口隆弘、大崎雄介、溝口到
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-071905
    • Filing Date
      2023
    • Related Report
      2023 Research-status Report

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Published: 2022-04-19   Modified: 2024-12-25  

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