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NDB・多施設レジストリー・単施設コホートの融合による関節リウマチの合併症の解明

Research Project

Project/Area Number 22K10414
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 58010:Medical management and medical sociology-related
Research InstitutionKyoto University

Principal Investigator

大西 輝  京都大学, 医学研究科, 特定講師 (60634269)

Project Period (FY) 2022-04-01 – 2025-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2024: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords関節リウマチ / レセプトデータベース / 単施設コホート研究 / 多施設共同レジストリー / NDB / コホート研究 / 合併症
Outline of Research at the Start

レセプトデータベースと多施設共同レジストリー、単施設コホート研究は、単一での使用には限界があり相補的に利用されるべきであるが、そのような活用がされることはあまりない。本研究では、これらの異なる3つのデータベースを有機的に利用することで、ランダム化比較試験では検討が困難なエビデンスの創出に取り組む。今回、関節リウマチ患者の合併症に関するアウトカムの改善に結び付けることを目標とし、レセプトデータベースと多施設共同レジストリー、単施設コホート研究の3つの規模の異なるデータを有機的に活用し、膨大な実臨床での診療データから新しい医学的エビデンスを創出する。

Outline of Annual Research Achievements

関節リウマチ患者では健常者に比べ、各種合併症の発生割合が高く、予後不良因子として知られている。例えば、RA患者では慢性腎臓病の発症割合が高く、腎機能の悪化は心血管イベントや死亡と関連している 。しかし、合併症を併発した患者への新規薬剤の安全性、新規薬剤の合併症への発生リスク、合併症の発症予防、発症予測は十分に検討されていない。
レセプトデータベース、多施設共同レジストリー、単施設コホートの3つの異なる研究データを有機的に利用することで、RA患者における合併症といった、特殊な患者のアウトカムの改善に結び付けていく。①レセプトデータベースとしてMDV、②多施設共同疾患レジストリーとしては関西7大学での多施設共同大規模RAレジストリー(ANSWERコホート)、③単施設コホート研究としては京都大学リウマチセンターコホート(KURAMAコホート)を利用している。①についてはMDVのデータを取得し、データクリーニングを実施している。②については生物学的製剤、JAK阻害薬による腎機能への影響を解析し、TNF阻害薬では腎機能を悪化させにくく、JAK阻害薬は悪化させる効果は低いことが分かった。現在論文化予定である。③については、採血・尿サンプルを取得したため、今後腎機能障害になるバイオマーカーを探索的に検討する。

Current Status of Research Progress
Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

十分な採血、尿サンプルの入手が遅れている。

Strategy for Future Research Activity

翌年度も引き続き、対象患者を広げ、サンプル入手に努める。

Report

(2 results)
  • 2023 Research-status Report
  • 2022 Research-status Report
  • Research Products

    (16 results)

All 2024 2023

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 16 results,  Open Access: 1 results)

  • [Journal Article] Avacopan's potential to decrease MPO-ANCA titres concurrent with ameliorated activity in ANCA-associated vasculitis.2024

    • Author(s)
      Tomoki Taniguchi; Ryosuke Hiwa; Mikihito Shoji; Eriho Yamaguchi; Mirei Shirakashi; Hideo Onizawa; Hideaki Tsuji; Koji Kitagori; Ran Nakashima; Shuji Akizuki; Akira Onishi; Hajime Yoshifuji; Masao Tanaka; Akio Morinobu
    • Journal Title

      Modern rheumatology case reports

      Volume: - Issue: 2 Pages: 314-317

    • DOI

      10.1093/mrcr/rxae016

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of high disease activity on spinal sagittal malalignment in patients with rheumatoid arthritis.2024

    • Author(s)
      Shintaro Honda; Koichi Murata; Shunsuke Fujibayashi; Bungo Otsuki; Takayoshi Shimizu; Takayuki Fujii; Yaichiro Okuzu; Toshiyuki Kawai; Yutaka Kuroda; Akira Onishi; Kosaku Murakami; Hideo Onizawa; Masao Tanaka; Akio Morinobu; Shuichi Matsuda
    • Journal Title

      Journal of neurosurgery. Spine

      Volume: - Issue: 1 Pages: 1-9

    • DOI

      10.3171/2024.1.spine231199

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of safety and effectiveness between etanercept biosimilar LBEC0101 and reference in patients with rheumatoid arthritis in real-world data using the KURAMA cohort.2024

    • Author(s)
      Tomoya Kawakami; Sho Masui; Akira Onishi; Hideo Onizawa; Takayuki Fujii; Kosaku Murakami; Koichi Murata; Masao Tanaka; Takashi Shimada; Shunsaku Nakagawa; Shuichi Matsuda; Akio Morinobu; Tomohiro Terada; Atsushi Yonezawa
    • Journal Title

      Modern rheumatology

      Volume: - Issue: 6 Pages: 1135-1141

    • DOI

      10.1093/mr/roae018

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predictive value of baseline concomitant glucocorticoid for abatacept-mediated long-term inhibition of radiographic progression: insights from the KURAMA cohort.2024

    • Author(s)
      Kosaku Murakami; Ryu Watanabe; Toshimitsu Fujisaki; Hiromu Ito; Koichi Murata; Wataru Yamamoto; Takayuki Fujii; Hideo Onizawa; Akira Onishi; Masao Tanaka; Motomu Hashimoto; Akio Morinobu
    • Journal Title

      Immunological medicine

      Volume: 47 Issue: 1 Pages: 45-51

    • DOI

      10.1080/25785826.2023.2265148

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Management and treatment outcomes of rheumatoid arthritis in the era of biologic and targeted synthetic therapies: evaluation of 10-year data from the KURAMA cohort.2024

    • Author(s)
      Takayuki Fujii; Koichi Murata; Hideo Onizawa; Akira Onishi; Masao Tanaka; Kosaku Murakami; Kohei Nishitani; Moritoshi Furu; Ryu Watanabe; Motomu Hashimoto; Hiromu Ito; Takao Fujii; Tsuneyo Mimori; Akio Morinobu; Shuichi Matsuda
    • Journal Title

      Arthritis research & therapy

      Volume: 26 Issue: 1 Pages: 16-16

    • DOI

      10.1186/s13075-023-03251-z

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of large joint involvement at the start of biological disease-modifying antirheumatic drugs and Janus kinase inhibitors with disease activity and drug retention in patients with rheumatoid arthritis: The ANSWER cohort study.2024

    • Author(s)
      Iku Shirasugi; Akira Onishi; Keisuke Nishimura; Wataru Yamamoto; Kosaku Murakami; Hideo Onizawa; Yuichi Maeda; Kosuke Ebina; Yonsu Son; Hideki Amuro; Masaki Katayama; Ryota Hara; Koji Nagai; Yuri Hiramatsu; Motomu Hashimoto; Tadashi Okano; Toshihisa Maeda; Shinya Hayashi; Sho Sendo; Sadao Jinno; Yuzuru Yamamoto; Hirota
    • Journal Title

      International journal of rheumatic diseases

      Volume: 27 Issue: 3

    • DOI

      10.1111/1756-185x.15097

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of retention of biologics in Japanese patients with elderly-onset rheumatoid arthritis-the ANSWER cohort study.2024

    • Author(s)
      Sadao Jinno; Akira Onishi; Shuhei Hattori; Maureen Dubreuil; Yo Ueda; Keisuke Nishimura; Takaichi Okano; Hirotaka Yamada; Wataru Yamamoto; Koichi Murata; Hideo Onizawa; Kosuke Ebina; Yuichi Maeda; Yonsu Son; Hideki Amuro; Ryota Hara; Kenichiro Hata; Hideyuki Shiba; Masaki Katayama; Ryu Watanabe; Motomu Hashimoto; Jun S
    • Journal Title

      Rheumatology (Oxford, England)

      Volume: - Issue: 2 Pages: 509-516

    • DOI

      10.1093/rheumatology/keae081

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparative effectiveness of biological disease-modifying antirheumatic drugs and Janus kinase inhibitor monotherapy in rheumatoid arthritis.2023

    • Author(s)
      Akira Onishi; Hirotaka Yamada; Wataru Yamamoto; Ryu Watanabe; Ryota Hara; Masaki Katayama; Yasutaka Okita; Yuichi Maeda; Hideki Amuro; Yonsu Son; Ayaka Yoshikawa; Kenichiro Hata; Motomu Hashimoto; Jun Saegusa; Akio Morinobu
    • Journal Title

      Rheumatology (Oxford, England)

      Volume: - Issue: 11 Pages: 3065-3073

    • DOI

      10.1093/rheumatology/kead620

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] POS0241?MONOCYTE-DERIVED TRANSCRIPTOMES EXPLAIN THE INEFFECTIVENESS OF ABATACEPT IN RHEUMATOID ARTHRITIS2023

    • Author(s)
      T. Iwasaki; R. Watanabe; H. Ito; T. Fujii; K. Ohmura; H. Yoshitomi; K. Murata; K. Murakami; A. Onishi; M. Tanaka; S. Matsuda; F. Matsuda; A. Morinobu; M. Hashimoto
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 82 Pages: 353-354

    • DOI

      10.1136/annrheumdis-2023-eular.970

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of?atypical IgG4-related disease presenting hypereosinophilia, polyneuropathy, and?liver dysfunction.2023

    • Author(s)
      Hiroki Mukoyama; Kosaku Murakami; Hideo Onizawa; Mirei Shirakashi; Ryosuke Hiwa; Hideaki Tsuji; Koji Kitagori; Shuji Akizuki; Ran Nakashima; Akira Onishi; Hajime Yoshifuji; Masao Tanaka; Akio Morinobu
    • Journal Title

      Modern rheumatology case reports

      Volume: 8 Issue: 1 Pages: 172-177

    • DOI

      10.1093/mrcr/rxad053

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Trends of disease activity in Japanese patients over 75 years with rheumatoid arthritis from 2014 to 2021- the ANSWER cohort study.2023

    • Author(s)
      Hirotaka Yamada; Sadao Jinno; Toshihisa Maeda; Shinya Hayashi; Wataru Yamamoto; Akira Onishi; Hideo Onizawa; Tohru Takeuchi; Yuri Hiramatsu; Yasutaka Okita; Kosuke Ebina; Yonsu Son; Naofumi Yoshida; Ryu Watanabe; Ryota Hara; Mai Yamashita; Yoko Nose; Yuzuru Yamamoto; Takaichi Okano; Keisuke Nishimura; Yo Ueda; Sho Send
    • Journal Title

      Rheumatology (Oxford, England)

      Volume: - Issue: 8 Pages: 2147-2151

    • DOI

      10.1093/rheumatology/kead539

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathogenicity of IgG-Fc desialylation and its association with Th17 cells in an animal model of systemic lupus erythematosus.2023

    • Author(s)
      Yuri Nishida; Mirei Shirakashi; Noritaka Hashii; Ran Nakashima; Yoichi Nakayama; Masao Katsushima; Ryu Watanabe; Hideo Onizawa; Ryosuke Hiwa; Hideaki Tsuji; Koji Kitagori; Shuji Akizuki; Akira Onishi; Kosaku Murakami; Hajime Yoshifuji; Masao Tanaka; Tatsuaki Tsuruyama; Akio Morinobu; Motomu Hashimoto
    • Journal Title

      Modern rheumatology

      Volume: 34 Issue: 3 Pages: 523-529

    • DOI

      10.1093/mr/road054

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] IL-6 inhibitors and JAK inhibitors as favourable treatment options for patients with anaemia and rheumatoid arthritis: ANSWER cohort study.2023

    • Author(s)
      Yoichi Nakayama; Ryu Watanabe; Wataru Yamamoto; Kosuke Ebina; Toru Hirano; Takuya Kotani; Hideyuki Shiba; Masaki Katayama; Yonsu Son; Hideki Amuro; Akira Onishi; Sadao Jinno; Ryota Hara; Kosaku Murakami; Koichi Murata; Hiromu Ito; Masao Tanaka; Shuichi Matsuda; Akio Morinobu; Motomu Hashimoto
    • Journal Title

      Rheumatology (Oxford, England)

      Volume: 63 Issue: 2 Pages: 349-357

    • DOI

      10.1093/rheumatology/kead299

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Twenty-year follow-up of promising clinical studies reported in highly circulated newspapers: a meta-epidemiological study.2023

    • Author(s)
      Aran Tajika; Yasushi Tsujimoto; Akira Onishi; Yusuke Tsutsumi; Satoshi Funada; Yusuke Ogawa; Nozomi Takeshima; Yu Hayasaka; Naotsugu Iwakami; Toshi A Furukawa
    • Journal Title

      BMJ health & care informatics

      Volume: 30 Issue: 1 Pages: e100768-e100768

    • DOI

      10.1136/bmjhci-2023-100768

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic Factors Affecting Death in Patients with Rheumatoid Arthritis Complicated by Pneumocystis jirovecii Pneumonia and One-Year Clinical Course: The ANSWER Cohort Study.2023

    • Author(s)
      Hideyuki Shiba; Takuya Kotani; Koji Nagai; Kenichiro Hata; Wataru Yamamoto; Ayaka Yoshikawa; Yumiko Wada; Yuri Hiramatsu; Hidehiko Makino; Yo Ueda; Akira Onishi; Koichi Murata; Hideki Amuro; Yonsu Son; Ryota Hara; Toru Hirano; Kosuke Ebina; Masaki Katayama; Motomu Hashimoto; Tohru Takeuchi
    • Journal Title

      International journal of molecular sciences

      Volume: 24 Issue: 8 Pages: 7399-7399

    • DOI

      10.3390/ijms24087399

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of personalized exercise program on physical function in elderly patients with rheumatoid arthritis at high risk for sarcopenia: study protocol for a randomized controlled trial2023

    • Author(s)
      Akira Onishi; Mie Torii; Yu Hidaka; Ryuji Uozumi; Yohei Oshima; Hiroki Tanaka; Hideo Onizawa; Takayuki Fujii; Koichi Murata; Kosaku Murakami; Masao Tanaka; Shuichi Matsuda; Akio Morinobu; Hidenori Arai; Motomu Hashimoto
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 24 Issue: 1 Pages: 280-280

    • DOI

      10.1186/s12891-023-06185-4

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research

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Published: 2022-04-19   Modified: 2024-12-25  

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