| Project/Area Number |
22K11030
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 58070:Lifelong developmental nursing-related
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| Research Institution | Kochi University |
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Principal Investigator |
JP NawAwn 高知大学, 医学部, 特任助教 (00835093)
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| Co-Investigator(Kenkyū-buntansha) |
滿田 直美 高知大学, 医学部, 特任助教 (30611389)
菅沼 成文 高知大学, 教育研究部医療学系連携医学部門, 教授 (50313747)
栄徳 勝光 高知大学, 教育研究部医療学系連携医学部門, 講師 (50552733)
山崎 慶子 高知大学, 医学部, 特任研究員 (90930446)
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| Project Period (FY) |
2022-04-01 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2024: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2022: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | chest circumference / head circumference / NAFLD / fetal growth restriction / metabolic syndrome |
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| Outline of Research at the Start |
During intrauterine life, placental insufficiency will cause differential redistribution of fetal cardiac output in favour of the developing brain. The affected fetus will become small overall, but size reduction can be more marked in the body than the head. Thus, the relative size of the chest and head at birth (chest/head circumference ratio) could provide retrospective information of intrauterine growth. We designed this longitudinal birth cohort study to examine how chest/head circumference ratio at birth and catch-up growth during infancy is associated with NAFLD in 8-year-old children.
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| Outline of Annual Research Achievements |
In the first fiscal year of this project, we collected comprehensive health information, anthropometric data, and blood samples from 2190 children. In the second fiscal year, we analyzed a range of biomarkers collected during the initial year. These include levels of liver enzymes (ALT, AST, and GGT), lipids (triglycerides, total cholesterol, HDL, LDL), HbA1c, adiponectin, uric acid, creatinine, and hs-CRP. Additionally, we successfully linked the information obtained at this project and the health data gathered during the stages of pregnancy through infancy. By using this merged dataset, we investigated the relationships between anthropometric data collected during these different stages and analyze how they correlate with liver and cardio-metabolic health outcomes in later childhood.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
We are in the process of investigating the relationship between anthropometric fetal growth indicators at birth, height and weight growth in early childhood, markers of adiposity, and liver enzymes in later childhood.
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| Strategy for Future Research Activity |
The integrated information, i.e., collected during pregnancy and infancy with the data obtained at the 8-year follow-up, presents a unique opportunity to explore the long-term effects and developmental trajectories of liver and cardio-metabolic health in children. Specifically, we will examine the relationships between anthropometric data collected during these different stages and analyze how they correlate with liver and cardio-metabolic health outcomes in later childhood.
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