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identifying and strenghtening the neural circuits of positive motivation

Research Project

Project/Area Number 22K11601
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionUniversity of Tsukuba

Principal Investigator

グレニエ フランソワ  筑波大学, 体育系, 研究員 (90738692)

Co-Investigator(Kenkyū-buntansha) 征矢 英昭  筑波大学, 体育系, 教授 (50221346)
Project Period (FY) 2022-04-01 – 2024-03-31
Project Status Discontinued (Fiscal Year 2023)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2024: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2023: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2022: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordslight exercise / motivation / electrophysiology / EEG / LFP / Motivation / Exercise / Electrophysiology / Treadmill / Running / Brain oscillations / Hippocampus / Health / mild running / local field potential
Outline of Research at the Start

We will use electrophysiological recording techniques, in combination with a behavioral task that helps identify positive motivational behavior to reveal the brain activities and structures that accompany the motivational benefits of the non-stressful mild-running exercise paradigm in rats.

Outline of Annual Research Achievements

During this project, we have developed techniques to do multi-site local field potentials in rats before, during, and after a light running exercise to identify the positive effects of this exercise on brain activities and structures related to positive motivation. We have recorded different brain parts, including the hippocampus (CA1) and cortex. I confirmed that light running increased theta activity up to 6 times. It also increased waking periods following exercise by up to 90 minutes. This demonstrates a general activating effect of light running. Hippocampal theta waves have been shown to be involved in physical activity, cognitive processes, and memory formation and recovery, so these results strongly support the hypothesis that light exercise positively impacts brain activity.

Report

(2 results)
  • 2023 Annual Research Report
  • 2022 Research-status Report
  • Research Products

    (5 results)

All 2022

All Presentation (5 results)

  • [Presentation] Acute light intensity exercise activates dopaminergic and noradrenergic coeruleo-dorsal hippocampal pathway.2022

    • Author(s)
      Taichi Hiraga, Toshiaki Hata, Ryo Shimoda, Francois Grenier, Shingo Soya, Joshua P. Johansen, Takashi Matsui, Masahiro Okamoto, Hideaki Soya
    • Organizer
      NEURO2022
    • Related Report
      2022 Research-status Report
  • [Presentation] Vitamin B1 derivative enhance physical activity via coeruleo-cortical catecholaminergic pathways.2022

    • Author(s)
      Toshiaki Hata, Taichi Hiraga, Francois Grenier, Masahiro Okamoto, Takashi Matsui, Hideaki Soya
    • Organizer
      NEURO2022
    • Related Report
      2022 Research-status Report
  • [Presentation] 一過性低強度走運動は海馬背側部シータ波パワーを増大する:in vivo電気生理学手法を用いた検討.2022

    • Author(s)
      Grenier Francois, 平賀大一, 秦俊陽, 征矢英昭
    • Organizer
      第77回日本体力医学会大会
    • Related Report
      2022 Research-status Report
  • [Presentation] ビタミンB1誘導体による青斑核-前頭皮質系を介した自発運動促進機構.2022

    • Author(s)
      秦俊陽, 平賀大一, グレニエフランソワ, 岡本正洋, 松井崇, 征矢英昭
    • Organizer
      第77回日本体力医学会大会
    • Related Report
      2022 Research-status Report
  • [Presentation] The impact of clonidine on the light exercise-induced arousal and hippocampal theta rhythm.2022

    • Author(s)
      Francois Grenier, Taichi Hiraga, Toshiaki Hata, Hideaki Soya
    • Organizer
      ARIHHPフォーラム2023
    • Related Report
      2022 Research-status Report

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Published: 2022-04-19   Modified: 2024-12-25  

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