Computational investigation on the efficacy and safety of the lesion preparation devices in calcified coronary artery with a cracking model of calcification

Research Project

Project/Area Number	22K12774
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 90110:Biomedical engineering-related
Research Institution	Waseda University
Principal Investigator	朱暁冬早稲田大学, 理工学術院, 次席研究員(研究院講師) (90813650)
Co-Investigator(Kenkyū-buntansha)	岩崎清隆早稲田大学, 理工学術院, 教授 (20339691)
Project Period (FY)	2022-04-01 – 2025-03-31
Project Status	Granted (Fiscal Year 2022)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	CDP model / fracture behavior / EMBC / compression test / calcification / finite element analysis / numerical cracking model / cutting/scoring balloon
Outline of Research at the Start	Refinements of lesion preparation devices with effectively fracturing calcification and reducing arterial injury is necessary. We aim to reveal the mechanics of calcification fracture with experimental tests and computational simulations to promote the development of the devices.
Outline of Annual Research Achievements	We successfully tested an available brittle cracking model, concrete damaged plasticity model (CDP), to confirm the fracture behavior of the calcification model using a demo data. The elements of the calcification model were removed when the value of strain reached the failure criteria of tensile strain. It provided a capability for modeling brittle cracking behavior. We processed a preferable cylindrical analogue material which mechanical property is close to the real calcification and performed experimental tests to obtain the compression stress-strain data.The peak stress is in good agreement with the value of the calcification. Recent research outcome of the CDP model tested in the numerical simulation will be presented in an international conference EMBC2023 in July.
Current Status of Research Progress	Current Status of Research Progress 3: Progress in research has been slightly delayed. Reason We tested an available brittle cracking model and conducted the compression test to obtain the behavior of the analogue material of calcification. A tensile test also will be performed to acquire the tensile stress-strain data. However, the cylindrical material is not suitable to be used in the tensile test and we have to modified the shape to ensure a successful tensile test. We are now reconstructing the shape and designing an available clamp to improve the tensile test. The experiment will be conducted in this month and finally both of the tensile and compression data will be obtained to be used in the definition of material property in FEM.
Strategy for Future Research Activity	After obtaining both of the tensile and compression stress-strain data of the analogue material of calcification, the CDP cracking model will be assigned to the FE model. The function of the fracture behavior will be verified and the numerical simulation of expanding cutting balloon model in the calcified artery model will be performed to confirm the pressure at the moment of fracture in comparison with the previous experiment.