| Project/Area Number |
22K12774
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 90110:Biomedical engineering-related
|
|---|
| Research Institution | Waseda University |
|---|
Principal Investigator |
朱 暁冬 早稲田大学, 理工学術院, 次席研究員(研究院講師) (90813650)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
岩崎 清隆 早稲田大学, 理工学術院, 教授 (20339691)
|
|---|
| Project Period (FY) |
2022-04-01 – 2025-03-31
|
| Project Status |
Granted (Fiscal Year 2023)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | cracking failure / concrete damaged / numerical simulation / CDP model / fracture behavior / EMBC / compression test / calcification / finite element analysis / numerical cracking model / cutting/scoring balloon |
|---|
| Outline of Research at the Start |
Refinements of lesion preparation devices with effectively fracturing calcification and reducing arterial injury is necessary.
We aim to reveal the mechanics of calcification fracture with experimental tests and computational simulations to promote the development of the devices.
|
| Outline of Annual Research Achievements |
To assist in conducting the tensile test, a dedicated tensile fixture model was originally designed and made by a 3D printer. The fixture model was used to fix the calcification sample on the tensile testing machine. Strain-stress data of the calcification samples were obtained and used in the cracking material model.
The numerical simulations were successfully performed for both cutting balloon model and non-compliant balloon models in a calcified artery model system. The pressures of expanding the calcification model and the results of the first principal stresses occurred in the artery models were obtained.
The outcomes have been presented at the international conference EMBC2023 and also will be presented at the 47th Annual Meeting of The Japanese Society of Biorheology.
|
| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The strain-stress data of the calcification model has been obtained from both tensile and compression test. Concrete damaged plasticity model was used to mimic the fracture failure of the calcification model in the numerical simulations. Both cutting balloon model and non-compliant balloon model were pressurized to expand and fracture the calcification model.
|
| Strategy for Future Research Activity |
The simulations of deflation of the cutting balloon model and non-compliant balloon model and thereafter stent deployment will be implemented. The deflated cutting/non-compliant balloon model will be removed, and a stent model will be arranged in the calcified artery model. The simulation of stent deployment will be carried out. The lumen gain, such as diameter and area in the calcified artery model, will be used to evaluate the treatment of using both cutting/non-compliant balloon and stent.
Furthermore, the dimensions of blades or wires, which are key roles of the cutting balloons, will be discussed to contribute the improvement of these medical devices via the artery-calcification system with the cracking model.
|
