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Optical measurement of tissue conductivity in microwave range with cell-level resolution

Research Project

Project/Area Number 22K14299
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 21060:Electron device and electronic equipment-related
Research InstitutionTokyo Institute of Technology

Principal Investigator

宋 航 (ソウ コウ)  東京工業大学, 環境・社会理工学院, 助教 (80907288)

Project Period (FY) 2022-04-01 – 2025-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2024: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2023: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsPermittivity measurement / Conductivity measurement / Microwave measurement / Millimeter wave / microwave measurement / optical measurement
Outline of Research at the Start

In this project, an innovative optical measurement technology will be developed for characterizing the conductivity of tissues at cell level by using quantum sensing. Measurement system and protocols will be developed to challenge the precise conductivity measurement of tissues at single-cell resolution (1 um), which can differentiate the characteristics of different cells in tissues. With the precise conductivity information in micron resolution which has never been achieved before, new research directions is promising to be created for novel microwave biomedical applications.

Outline of Annual Research Achievements

In this year, a new method named small distance increment method was developed to estimate the complex permittivity of the material. In the proposed method, the transmitter and receiver were formed as the monostatic radar, which is facing towards the material under test. During the measurement, the distance between radar and material changes with small increments and the signals are recorded at each position. A mathematical model is formulated to depict the relationship among the complex permittivity, distance increment, and measured signals. By fitting the model, the complex permittivity of material was successfully estimated. Furthermore, an imaging system was developed to measure the distribution of the reflectivity of a designated region. The propagation of the wave for imaging was also simulated by proposing a hybrid approach. This hybrid approach is composed by geometrical optics and physical optics methods. The transmission of the wave through shielding material is calculated by geometrical optics and the reflection from the target material is calculated by physical optics. By comparing the measurement and simulation, the good agreement was achieved. Through measuring the reflectivity distribution, the distribution complex permittivity in the region can be estimated.

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

A new method was proposed to conduct the complex permittivity estimation, and an imaging system was developed which can demonstrate the reflectivity distribution of a certain area. The reflectivity is related to the complex permittivity which is able to be utilized for calculating the conductivity. These achievements can promote the development of the fused optical and microwave system for conductivity measurement.

Strategy for Future Research Activity

For the next year, the fused optical and microwave system will be developed to measure the conductivity. The relationship between the optical image and the conductivity will be further studied and clarified.

Report

(2 results)
  • 2023 Research-status Report
  • 2022 Research-status Report
  • Research Products

    (8 results)

All 2024 2023 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] Tianjin University(中国)

    • Related Report
      2022 Research-status Report
  • [Journal Article] Cross-Correlation of Confocal Images for Excised Breast Tissues of Total Mastectomy2024

    • Author(s)
      Hang Song, Shinsuke Sasada, Takayuki Kadoya, Koji Arihiro, Morihito Okada, Xia Xiao, Tomomi Ishikawa, Declan O'Loughlin, Jun-ichi Takada, and Takamaro Kikkawa
    • Journal Title

      IEEE Transactions on Biomedical Engineering

      Volume: vol. 71, no. 5 Issue: 5 Pages: 1705-1716

    • DOI

      10.1109/tbme.2023.3348480

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Fused Learning and Enhancing Method for Accurate and Noninvasive Hydration Status Monitoring With UWB Microwave Based on Phantom2023

    • Author(s)
      Peng Lu、Song Hang、Xiao Xia、Liu Guancong、Lu Min、Liu Yu、Wei Bo、Kikkawa Takamaro
    • Journal Title

      IEEE Transactions on Microwave Theory and Techniques

      Volume: early access Issue: 9 Pages: 1-10

    • DOI

      10.1109/tmtt.2023.3248788

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] RSSI-CSI Measurement and Variation Mitigation With Commodity Wi-Fi Device2023

    • Author(s)
      Wei Bo、Song Hang、Katto Jiro、Kikkawa Takamaro
    • Journal Title

      IEEE Internet of Things Journal

      Volume: 10 Issue: 7 Pages: 6249-6258

    • DOI

      10.1109/jiot.2022.3223525

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Presentation] Measurement of complex permittivity by FMCW radar: investigating the influence of distance on the reflected signal2023

    • Author(s)
      Hang. Song, Mingxia Wan, and Jun-ichi Takada
    • Organizer
      XXXVth URSI General Assembly and Scientific Symposium
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Radio propagation simulation by hybrid physical and geometrical optics approximation for target imaging under the presence of dielectric shielding2023

    • Author(s)
      Kaito Ichijo, Hang Song, Xin Du, and Jun-ichi Takada
    • Organizer
      2024 IEICE General Conference
    • Related Report
      2023 Research-status Report
  • [Presentation] Study on the measurement of complex dielectric constant by using FMCW radar2023

    • Author(s)
      Mingxia Wan, Hang Song, Junichi Takada
    • Organizer
      IEICE 総合大会 2023
    • Related Report
      2022 Research-status Report
  • [Presentation] Measurement of complex permittivity by FMCW radar: investigating the influence of distance on the reflected signal2023

    • Author(s)
      Hang Song, Mingxia Wan, and Jun-ichi Takada
    • Organizer
      The XXXVth URSI General Assembly and Scientific Symposium (URSI GASS 2023)
    • Related Report
      2022 Research-status Report

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Published: 2022-04-19   Modified: 2024-12-25  

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