| Project/Area Number |
22K14350
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 22060:Environmental systems for civil engineering-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2022-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2023: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2022: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | トキシコゲノミクス / 細胞毒性 / 水晶振動子マイクロバランス / 下水再利用 / EEM / 異常検知 / 内分泌撹乱物質 / 医薬品 / 合成ホルモン / 下水由来溶存有機物 / 未規制化学物質 / 複合毒性 |
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| Outline of Research at the Start |
下水処理水は，処理過程で生じる副生成物・代謝物，微生物由来の溶解性有機物，水道水由来の自然有機物等が織り成す複雑な処理水マトリクスである．本研究では，下水処理水マトリクスと未規制化学物質の複合作用を明らかにするため，水晶振動子マイクロバランスを用いて下水処理水マトリクスと化学物質の吸着特性を調べるとともに，ヒト細胞の網羅的遺伝子発現解析により処理水マトリクスと化学物質の複合影響を明らかにする．
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| Outline of Final Research Achievements |
In this study, the hydrophobic fractions of treated sewage water were fractionated into acidic, neutral and basic fractions to clarify the combined effects of these fractions and unregulated chemicals on human cultured cells, as well as the combined effects of these fractions and unregulated chemicals on human cultured cells by quartz crystal microbalance (QCM) to clarify the combined effects of the treated sewage water matrix and unregulated chemicals. The amount of adsorption was evaluated by quartz crystal microbalance (QCM). The results suggest that the cellular effects of synthetic hormones are reduced in the presence of the treated water matrix. The QCM analysis also showed that the adsorption characteristics of synthetic hormones on each fraction differed depending on the type of synthetic hormone. To ensure the safety of reused water, water quality management should take into account the role of the treated water matrix.
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| Academic Significance and Societal Importance of the Research Achievements |
研究成果により，再利用水の安全性を確保するために、処理水マトリクスの役割を考慮した水質管理の重要であることが明らかとなった．また，本研究で用いた手法を他の未規制化学物質に適用することにより，監視・制御の対象となる化学物質の優先づけが可能となると考える．さらに，処理水マトリクスには多くの自然由来有機物が含まれていることから，吸着特性データは，自然の水環境中での微量汚染物質の挙動や毒性影響を研究する上でも役立つ．
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