| Project/Area Number |
22K14535
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 27020:Chemical reaction and process system engineering-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
バドラ サラ・サミール・レヤド 東京大学, 大学院工学系研究科(工学部), 准教授 (20842206)
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| Project Period (FY) |
2022-04-01 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2024: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2023: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Freeze drying / Process optimization / Biopharmaceuticals / Modelling / Process design / Hybrid modelling / freeze-drying / process optimization / mechanistic modelling / cake collapse |
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| Outline of Research at the Start |
This work develops multiscale hybrid models to rationalize the design and operation of freeze-drying processes. The models can be used for process optimization, failure detection to improve supply robustness of biopharmaceuticals, and further to increase the flexibility of drug distribution.
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| Outline of Annual Research Achievements |
Freeze drying is essential to allow the storage and distribution of unstable biopharmaceuticals, e.g., therapeutic proteins. However, the process is time-and resource-intensive. This research aims to provide design and operation improvements to save production time without affecting product quality. Collaborations with industrial partners were established. The collected data from was used to develop process models for different operations, e.g., drying. The drying process is one of the most time-consuming steps and vulnerable to issues affecting the product quality. An index was developed relating product quality issues with changes in physical properties for standard materials used as additives.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The work is progressing according to plan. Vial scale models have been developed for the drying process. An index for product quality has been developed. Collaborations with industrial partners are proceeding smoothly.
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| Strategy for Future Research Activity |
In the future, the model will be integrated with the quality index to optimize the freeze-drying operation and provide a guide based on material properties and process conditions. Process optimization using the developed integrated model will take place.
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