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Neuronal Basis for Loss Sensitivity-Based Exploratory Behavior

Research Project

Project/Area Number 22K15226
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 46030:Function of nervous system-related
Research InstitutionKyoto University

Principal Investigator

Nonomura Satoshi  京都大学, ヒト行動進化研究センター, 特定助教 (10737125)

Project Period (FY) 2022-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2022: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords意思決定 / 光遺伝学 / 電気生理学 / 前頭前皮質 / 線条体 / 前頭前皮質ー線条体回路 / 電気生理 / 行動選択 / 報酬の損失感受性に基づく探索行動課題 / 報酬の損失感受性
Outline of Research at the Start

科学技術の進歩や、感染症の流行などによる劇的な変化を特徴とする現代社会において、我々は、快適にそして安全に社会生活を送るために、変化に応じた柔軟な行動選択を行っている。柔軟な行動選択は、脳における重要な意思決定機能の一つである。本研究は、マカクザル及びラットを対象とした先端技術を用いた神経生理学的実験と、数理モデルを用いた計算論的なアプローチによって、従来、科学的な対象として捉えることが難しかった脳の意思決定機能の情報処理基盤を高時間・高空間解像度で精密に明らかにすることを目指す。

Outline of Final Research Achievements

Sensing the diminishment of value of repeatedly selected behaviors in a dynamic environment and switching behaviors in an exploratory manner in search of better conditions is an important decision-making function in modern society characterized by change. In this study, we conducted experiments in rats and macaque monkeys using a combination of optogenetics and electrophysiology techniques to elucidate the neural basis of the brain involved in behavior switching based on value diminishment. The results revealed that neural pathways from the medial prefrontal cortex to the basal ganglia(striatum) transmit important signals involved in such behavior switching.

Academic Significance and Societal Importance of the Research Achievements

本研究では、損失に基づいた行動切り替えに関わるシグナルがどのように伝達されているのかを、光遺伝学技術と電気生理学的手法を応用することで、神経路を厳密に特定した上で明らかにした。こうした成果は、経済的、社会的、精神的な支障がきたされるギャンブル依存や固執行動などの異常な意思決定機能の理解や、その治療法の提案につながることが考えられる。

Report

(3 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • Research Products

    (9 results)

All 2023 2022 Other

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Reward expectation enhances action-related activity of nigral dopaminergic and two striatal output pathways2023

    • Author(s)
      Rios Alain、Nonomura Satoshi、Kato Shigeki、Yoshida Junichi、Matsushita Natsuki、Nambu Atsushi、Takada Masahiko、Hira Riichiro、Kobayashi Kazuto、Sakai Yutaka、Kimura Minoru、Isomura Yoshikazu
    • Journal Title

      Communications Biology

      Volume: 6 Issue: 1 Pages: 914-914

    • DOI

      10.1038/s42003-023-05288-x

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rat hippocampal CA1 region represents learning-related action and reward events with shorter latency than the lateral entorhinal cortex2023

    • Author(s)
      Soma Shogo、Ohara Shinya、Nonomura Satoshi、Suematsu Naofumi、Yoshida Junichi、Pastalkova Eva、Sakai Yutaka、Tsutsui Ken-Ichiro、Isomura Yoshikazu
    • Journal Title

      Communications Biology

      Volume: 6 Issue: 1 Pages: 584-584

    • DOI

      10.1038/s42003-023-04958-0

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Neural representation of medial prefrontal cortex and striatal indirect pathway neuron for diminishing reward-based action switch2023

    • Author(s)
      Nonomura S, Kaneko T, Amita H, Inoue K, Takada M
    • Organizer
      2023 Annual Meeting of the Society for Neuroscience
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Medial prefrontal cortex neuron negatively controls action switch based on diminishing reward in rats2023

    • Author(s)
      Nonomura S, T. Takayasu, T. Kaneko, H. Amita, K. Inoue and M. Takada
    • Organizer
      XIVth Meeting for International Basal Ganglia Society
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Medial prefrontal cortex neuron activity in relation to diminishing reward-based action selection in rats2023

    • Author(s)
      野々村 聡
    • Organizer
      生理研-新潟脳研-ヒト進化研究センター 合同シンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Signals from medial prefrontal cortex negatively control action selection based on reward diminishing2023

    • Author(s)
      Nonomura S, Kaneko T, Amita H, Inoue K, Takada M
    • Organizer
      The 46th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2023 Annual Research Report
  • [Presentation] Medial prefrontal cortex neurons negatively control action selection based on reward diminishing2023

    • Author(s)
      S. Nonomura, T. Kaneko, H. Amita, K. Inoue and M. Takada
    • Organizer
      XIV Meeting of the International Basal Ganglia Society
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Medial prefrontal cortex neuron activity in relation to diminishing reward-based action selection in rats2022

    • Author(s)
      S. Nonomura, T. Takayasu, T. Kaneko, H. Amita, K. Inoue and M. Takada
    • Organizer
      2022 Annual Meeting of the Society for Neuroscience,
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Remarks] 「 最近の成功を活かして適切な行動を選択する脳の仕組みを解明 」

    • URL

      https://www.tmd.ac.jp/press-release/20230912-1/

    • Related Report
      2023 Annual Research Report

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Published: 2022-04-19   Modified: 2025-01-30  

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