Creation and biological evaluation of nanoparticle-based artificial transcription factor

Research Project

Project/Area Number	22K15249
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Research Institution	Kyoto University
Principal Investigator	CHINNATHAMBI Shanmugavel 京都大学, 高等研究院, 特定研究員 (60922341)
Project Period (FY)	2022-04-01 – 2024-03-31
Project Status	Granted (Fiscal Year 2022)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2023: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2022: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	NANO-TF / Silica nanoparticles / Mitochondrial factors
Outline of Research at the Start	Cancer is the leading cause of death worldwide. Recent studies have revealed the importance of reactive oxygen species produced by mitochondrial complex I in cancer disease and their associated signaling pathways and epigenetic regulation. It is believed that this NANO-TF can control ROS levels and intracellular energy metabolism in patients with cancer disease and provide innovative strategies for treating cancer.