| Project/Area Number |
22K15252
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2022-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2022: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | natural product extract / chemical diversification / metal catalyst / lead compound |
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| Outline of Research at the Start |
Natural products (NPs) play invaluable roles for drug discovery and development. However, during last two decades, the de-emphasis of NP research correlated to overall reduction in new leads and drug approval. To create brand new biologically active compounds from NPs, we set up our methodology by using of diversity-oriented synthesis of NP extracts, via metal nanoparticle catalysts. This synthesis could directly access a number of NP-like compounds in one-step. Our new approach is promising for faster and more efficient drug discovery and development.
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| Outline of Final Research Achievements |
We have developed a methodology for creating and discovering new biologically active compounds using natural resources and highly reactive metal nanoparticle catalysts. Our approach uniquely employs nanoparticle catalysts, such as Pd, to efficiently catalyze C-H bond activation, C-C cleavage, and cross-coupling reactions, facilitating the formation of new natural product-like compounds in one step. Our research successfully demonstrated the direct chemical diversification of natural product extracts from marine sponges, leading to the discovery of a new compound, rac-6-OEt-cylindradine A. These findings underscore the potential of our method for faster and more efficient drug discovery and development. We are further enhancing this methodology by developing highly reactive Rh nanoparticle catalysts. Research Achievements: two peer-reviewed publications and two conference presentations, one at an international conference
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| Academic Significance and Societal Importance of the Research Achievements |
Our research advances drug discovery by using metal nanoparticle catalysts to create new biologically active compounds from natural product extracts. This innovative approach accelerates pharmaceutical development, offering potential treatments for various diseases.
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