Creation of New Lead Compounds using Natural Resources and Metal Nanoparticle Catalysts
| Project/Area Number |
22K15252
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2022-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2022: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | natural product extract / chemical diversification / metal catalyst / lead compound |
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| Outline of Research at the Start |
Natural products (NPs) play invaluable roles for drug discovery and development. However, during last two decades, the de-emphasis of NP research correlated to overall reduction in new leads and drug approval. To create brand new biologically active compounds from NPs, we set up our methodology by using of diversity-oriented synthesis of NP extracts, via metal nanoparticle catalysts. This synthesis could directly access a number of NP-like compounds in one-step. Our new approach is promising for faster and more efficient drug discovery and development.
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| Outline of Annual Research Achievements |
Our recent research extends previous success in diversification of natural product extracts. We have focused on employing Palladium nanoparticle catalyst for enhanced chemical diversification. These catalyst offers efficient catalysis of C-H bond activation, C-C cleavage, and cross-coupling reactions, facilitating the creation of diverse molecular scaffolds through C-C and/or C-heteroatom bond formations, thus generating new molecular structures. Additionally, we are currently developing highly reactive Rhodium nanoparticle catalyst, which hold promise for further expanding the scope and efficacy of chemical diversification. Our research underscores the potential of nanoparticle catalysts in driving innovative and sustainable approaches, with implications for advancing the exploration and exploitation of natural product diversity for pharmaceutical applications.
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Report
(2 results)
Research Products
(4 results)
