A novel mechanism of fibronectin/LILRB4 immune checkpoint in the regulation of the tumor microenvironment

Research Project

Project/Area Number	22K15519
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 50010:Tumor biology-related
Research Institution	Tohoku University
Principal Investigator	蘇美慈東北大学, 加齢医学研究所, 助教 (00812116)
Project Period (FY)	2022-04-01 – 2025-03-31
Project Status	Granted (Fiscal Year 2022)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2024: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2022: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	LILRB4 / exosome / fibronectin
Outline of Research at the Start	In this proposal, we will examine whether the exosome content profile of cancer-bearing mice and cancer patients changes when the FN-LILRB4 checkpoint is targeted and modified. This approach may provide a new assessment method for the prognosis of immune-targeting therapies.