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早期精神病におけるマルチモダル脳指標は認知機能軌跡を予測するか:アジア多施設研究

Research Project

Project/Area Number 22K15745
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionUniversity of Toyama

Principal Investigator

笹林 大樹  富山大学, 学術研究部医学系, 講師 (80801414)

Project Period (FY) 2022-04-01 – 2027-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2026: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2025: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2024: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords早期精神病 / 認知機能障害 / MRI / FEP / ARMS / ACMP / 早期介入 / バイオマーカー / 精神病発症危険群 / 初回エピソード精神病 / アジア精神病MRI研究コンソーシアム / 認知機能
Outline of Research at the Start

精神病性障害における認知機能障害は発症以前から存在して臨床症状や機能的転帰と関連し、患者の生活機能に対し強い影響力を持つ。疾患経過中の認知機能の軌跡は症例毎に異なっており、病態の進行を反映しているかもしれない。本研究では、アジア精神病MRI研究コンソーシアムで集積した多数例の初回エピソード精神病群および精神病発症危険群を対象に、構造方程式モデリングを用いて認知機能の軌跡を軸に脳形態/脳波所見を含むマルチモダル脳指標および臨床/機能転帰との因果関係を調べる。本研究の成果は精神病性障害において病態の進行を予測できるバイオマーカーを同定し、プレシジョン精神医学の実現に近づける可能性がある。

Outline of Annual Research Achievements

精神病性障害における認知機能障害は発症以前から存在して臨床症状や機能的転帰と関連し、患者の生活機能に対し強い影響力を有する。認知機能障害は固定的 変化ではなく疾患経過中の 認知機能の軌跡は症例毎に異なっており、病態の進行を反映している可能性がある。精神病性障害における早期介入は治療臨界期の 進行性脳変化を防ぐことで長期予後の改善に導く可能性があるものの、現時点では前駆期や病初期において病態の進行を予測できるバイオマーカーは存在しない。本研究では、アジア精神病MRI研究コンソーシアム (ACMP) で集積した多数例の初回エピソード精神病群および精神病性障害の発症危険群を対象に、構造方程式モデリングを用いて認知機能の軌跡を軸に脳形態/脳波所見を含むマルチモダル脳指標および臨床/機能転帰との因果関係を調べることを目的とする。本研究の成果を得ることで、精神病性障害において病態の進行を予測できるバイオマーカーを同定し、プレシジョン精神医学の実現に近づける可能性がある。
2022年度、研究代表者は、ACMPと連絡を取り合って解析パイプラインの確認を行い、本研究計画に必要な臨床およびMRIデータの欠損の確認および 欠損しているデータの補充を行った。また、先行研究の著者 (研究協力者:東京大学 小池進介) とオンラインミーティング等で複数回打ち合わせを行い、MRI機種間差を克服するためのharmonization技術や構造方程式モデリングなどの統計手法について習熟を進めた。
2023年度、研究代表者は、米国ハーバード大学ブリガムアンドウィメンズ病院精神画像研究所に長期出張し、本研究に用いる脳構造指標の選択肢を増やすべく、最先端の拡散テンソル技術の習得およびマルチモダリティ脳画像研究に従事した。

Current Status of Research Progress
Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

2019年後半より顕在化した新型コロナウイルス感染症拡大の影響が中国をはじめとしたアジア諸国に認められており、依然として収束には至っていないことか ら、人的交流などが十分行えておらず、ACMPのデータ構築が遅延している。
一方で、harmonization技術、統計手法、拡散テンソル解析技術、およびマルチモダリティ研究の運用など、本研究の遂行の準備段階となる技術蓄積は着実に進めている。

Strategy for Future Research Activity

オンラインでのやりとりなどを通して、ACMPのデータ構築を推進させ、まずは本研究の遂行に必要十分なデータセットを揃える。関連機関の多さ、国際共同研究であることなどから、当初の予定よりもデータセット構築に苦慮しているが、粘り強く交渉を進める。
また、近年のマルチモダリティ解析はどんどん解析が高度化していることから、最先端技術にキャッチアップできるよう、引き続き広い視野で解析技術蓄積を進めていく。

Report

(2 results)
  • 2023 Research-status Report
  • 2022 Research-status Report
  • Research Products

    (38 results)

All 2023 2022 2020 Other

All Int'l Joint Research (7 results) Journal Article (20 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 20 results,  Open Access: 18 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Int'l Joint Research] Peking University Sixth Hospital/Shanghai Mental Health Center/Sichuan University(中国)

    • Related Report
      2023 Research-status Report
  • [Int'l Joint Research] CHA Bundang Medical Center/Chonbuk National University Hospital/Seoul National University Hospital(韓国)

    • Related Report
      2023 Research-status Report
  • [Int'l Joint Research] National Cheng Kung University Hospital/National Taiwan University Hospital(その他の国・地域)

    • Related Report
      2023 Research-status Report
  • [Int'l Joint Research] Harvard Medical Schoool(米国)

    • Related Report
      2023 Research-status Report
  • [Int'l Joint Research] Peking University Sixth Hospital/Shanghai Mental Health Center/Sichuan University(中国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] CHA Bundang Medical Center/Chonbuk National University Hospital/Seoul National University Hospital(韓国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] National Cheng Kung University Hospital/National Taiwan University Hospital(その他の国・地域)

    • Related Report
      2022 Research-status Report
  • [Journal Article] Increased prevalence of the Heschl's gyrus duplication pattern common to various first-episode psychoses2023

    • Author(s)
      Takahashi Tsutomu、Sasabayashi Daiki、Wood Stephen J.、McGorry Patrick D.、Suzuki Michio、Velakoulis Dennis、Pantelis Christos
    • Journal Title

      Schizophrenia Research

      Volume: 252 Pages: 36-38

    • DOI

      10.1016/j.schres.2022.12.020

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Resting state hyperconnectivity of the default mode network in schizophrenia and clinical high-risk state for psychosis2023

    • Author(s)
      Sasabayashi Daiki、Takahashi Tsutomu、Takayanagi Yoichiro、Nemoto Kiyotaka、Ueno Maya、Furuichi Atsushi、Higuchi Yuko、Mizukami Yuko、Kobayashi Haruko、Yuasa Yusuke、Noguchi Kyo、Suzuki Michio
    • Journal Title

      Cerebral Cortex

      Volume: 33 Issue: 13 Pages: 8456-8464

    • DOI

      10.1093/cercor/bhad131

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anatomical variations in the insular cortex in individuals at a clinical high-risk state for psychosis and patients with schizophrenia2023

    • Author(s)
      Takahashi Tsutomu、Sasabayashi Daiki、Takayanagi Yoichiro、Higuchi Yuko、Mizukami Yuko、Akasaki Yukiko、Nishiyama Shimako、Furuichi Atsushi、Kobayashi Haruko、Yuasa Yusuke、Tsujii Noa、Noguchi Kyo、Suzuki Michio
    • Journal Title

      Frontiers in Psychiatry

      Volume: 14 Pages: 1192854-1192854

    • DOI

      10.3389/fpsyt.2023.1192854

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolic changes in the plasma of mild Alzheimer’s disease patients treated with Hachimijiogan2023

    • Author(s)
      Kainuma Mosaburo、Kawakatsu Shinobu、Kim Jun-Dal、Ouma Shinji、Iritani Osamu、Yamashita Ken-Ichiro、Ohara Tomoyuki、Hirano Shigeki、Suda Shiro、Hamano Tadanori、Hieda Sotaro、Yasui Masaaki、Yoshiiwa Aoi、Shiota Seiji、Hironishi Masaya、Wada-Isoe Kenji、Sasabayashi Daiki、et al
    • Journal Title

      Frontiers in Pharmacology

      Volume: 14 Pages: 1203349-1203349

    • DOI

      10.3389/fphar.2023.1203349

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analysis of polyunsaturated fatty acids in antipsychotic-free individuals with at-risk mental state and patients with first-episode schizophrenia2023

    • Author(s)
      Le Anh Thi Phuong、Higuchi Yuko、Sumiyoshi Tomiki、Itoh Hiroko、Sasabayashi Daiki、Takahashi Tsutomu、Suzuki Michio
    • Journal Title

      Frontiers in Psychiatry

      Volume: 14 Pages: 1188452-1188452

    • DOI

      10.3389/fpsyt.2023.1188452

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gross anatomical variations of the insular cortex in first-episode schizophrenia2023

    • Author(s)
      Takahashi Tsutomu、Sasabayashi Daiki、Takayanagi Yoichiro、Furuichi Atsushi、Kobayashi Haruko、Yuasa Yusuke、Noguchi Kyo、Suzuki Michio
    • Journal Title

      Schizophrenia Research

      Volume: 260 Pages: 23-29

    • DOI

      10.1016/j.schres.2023.07.032

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Birth season and gross brain morphology associated with early neurodevelopment in schizophrenia spectrum patients and healthy subjects2023

    • Author(s)
      Takahashi Tsutomu、Sasabayashi Daiki、Takayanagi Yoichiro、Kobayashi Haruko、Torigoe Misako、Sakamoto Kazumi、Yuasa Yusuke、Tsujii Noa、Noguchi Kyo、Suzuki Michio
    • Journal Title

      Psychiatry Research: Neuroimaging

      Volume: 335 Pages: 111714-111714

    • DOI

      10.1016/j.pscychresns.2023.111714

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Editorial: Prognostic imaging biomarkers in psychotic disorders2022

    • Author(s)
      Sasabayashi Daiki、Koike Shinsuke、Nakajima Shinichiro、Hirano Yoji
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13 Pages: 1053836-1053836

    • DOI

      10.3389/fpsyt.2022.1053836

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment2022

    • Author(s)
      Wada M, Noda Y, Iwata Y, Tsugawa S, Yoshida K, Tani H, Hirano Y, et al
    • Journal Title

      Molecular Psychiatry

      Volume: in press Issue: 7 Pages: 2950-2967

    • DOI

      10.1038/s41380-022-01572-0

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increased brain gyrification and subsequent relapse in patients with first-episode schizophrenia2022

    • Author(s)
      Sasabayashi Daiki、Takayanagi Yoichiro、Takahashi Tsutomu、Furuichi Atsushi、Kobayashi Haruko、Noguchi Kyo、Suzuki Michio
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13 Pages: 937605-937605

    • DOI

      10.3389/fpsyt.2022.937605

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis2022

    • Author(s)
      Baldwin Helen、...Sasabayashi Daiki、...Takahashi Tsutomu、
    • Journal Title

      Translational Psychiatry

      Volume: 12 Issue: 1 Pages: 297-297

    • DOI

      10.1038/s41398-022-02057-y

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Different Heschl’s Gyrus Duplication Patterns in Deficit and Non-deficit Subtypes of Schizophrenia2022

    • Author(s)
      Takahashi Tsutomu、Sasabayashi Daiki、Takayanagi Yoichiro、Furuichi Atsushi、Kobayashi Haruko、Noguchi Kyo、Suzuki Michio
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13 Pages: 867461-867461

    • DOI

      10.3389/fpsyt.2022.867461

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development and validation of a scale of self-alienation-related attributes for the early diagnosis of schizophrenia2022

    • Author(s)
      Nishiyama Shimako、Kurachi Masayoshi、Higuchi Yuko、Takahashi Tsutomu、Sasabayashi Daiki、Mizukami Yuko、Suzuki Michio
    • Journal Title

      Journal of Psychiatric Research

      Volume: 147 Pages: 212-220

    • DOI

      10.1016/j.jpsychires.2022.01.020

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] An exploratory, open-label, randomized, multicenter trial of hachimijiogan for mild Alzheimer’s disease2022

    • Author(s)
      Kainuma M, Ouma S, Kawakatsu S, Iritani O, Yamashita KI, Ohara T, Hirano S, Suda S, Hamano T, Hieda S, Yasui M, Yoshiiwa A, Shiota S, Hironishi M, Wada-Isoe K, Sasabayashi D, Yamasaki S, Murata M, Funakoshi K, Hayashi K, Shirafuji N, Sasaki H, Kajimoto Y, Mori Y, Suzuki M, Ito H, Ono K, Tsuboi Y.
    • Journal Title

      Frontiers in Pharmacology

      Volume: 13 Pages: 991982-991982

    • DOI

      10.3389/fphar.2022.991982

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Volume reduction of the dorsal lateral prefrontal cortex prior to the onset of frank psychosis in individuals with an at-risk mental state.2022

    • Author(s)
      Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Katagiri N, Sakuma A, Ohmuro N, Katsura M, Nakamura M, Kido M, Furuichi A, Nishikawa Y, Noguchi K, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M
    • Journal Title

      Cerebral Cortex

      Volume: in press Issue: 10 Pages: 2245-2253

    • DOI

      10.1093/cercor/bhab353

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Different Frequency of Heschl’s Gyrus Duplication Patterns in Neuropsychiatric Disorders: An MRI Study in Bipolar and Major Depressive Disorders2022

    • Author(s)
      Takahashi Tsutomu、Sasabayashi Daiki、Y?cel Murat、Whittle Sarah、Lorenzetti Valentina、Walterfang Mark、Suzuki Michio、Pantelis Christos、Malhi Gin S.、Allen Nicholas B.
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 16 Pages: 917270-917270

    • DOI

      10.3389/fnhum.2022.917270

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Decreased Cortical Gyrification and Surface Area in the Left Medial Parietal Cortex in Patients with Treatment-Resistant and Ultra-Treatment-Resistant Schizophrenia2022

    • Author(s)
      Kazutoshi Kitajima, Shunsuke Tamura, Daiki Sasabayashi, et al.
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 77 Issue: 1 Pages: 2-11

    • DOI

      10.1111/pcn.13482

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Recent Advances and Future Directions in Brain MR Imaging Studies in Schizophrenia: Toward Elucidating Brain Pathology and Developing Clinical Tools2022

    • Author(s)
      Shinsuke Koike, Akiko Uematsu, Daiki Sasabayashi, Norihide Maikusa, Tsutomu Takahashi, Kazutaka Ohi, Shinichiro Nakajima, Yoshihiro Noda, Yoji Hirano
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 21 Issue: 4 Pages: 539-552

    • DOI

      10.2463/mrms.rev.2021-0050

    • NAID

      130008076114

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gross anatomical features of the insular cortex in schizophrenia and schizotypal personality disorder: Potential relationships with vulnerability, illness stages, and clinical subtypes2022

    • Author(s)
      Takahashi Tsutomu、Sasabayashi Daiki、Takayanagi Yoichiro、Furuichi Atsushi、Kobayashi Haruko、Yuasa Yusuke、Noguchi Kyo、Suzuki Michio
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13 Pages: 1050712-1050712

    • DOI

      10.3389/fpsyt.2022.1050712

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thalamic and striato-pallidal volumes in schizophrenia patients and individuals at risk for psychosis: A multi-atlas segmentation study.2020

    • Author(s)
      Takahashi T, Tsugawa S, Nakajima S, Plitman E, Chakravarty MM, Masuda F, Wada M, Kurose S, Ochi R, Matsushita K, Sasabayashi D, Nakamura M, Nishikawa Y, Takayanagi Y, Nishiyama S, Higuchi Y, Mizukami Y, Furuichi A, Kido M, Hashimoto R, Noguchi K, Fujii S, Mimura M, Noda Y, Suzuki M.
    • Journal Title

      Schizophr Res.

      Volume: 20 Pages: 268-275

    • DOI

      10.1016/j.schres.2020.04.016

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Mega-analysis of differentiation of schizophrenia using structural MRI with consideration of scanner differences2023

    • Author(s)
      Hashimoto N, Nemoto K, Fukunaga M, Matsumoto J, Miura K, Okada N, Morita K, Koshiyama D, Ohi K, Takahashi T, Koeda M, Yamamori H, Fujimoto M, Yasuda Y, Hasegawa N, Ito S, Narita H, Yokoyama S, Mishima R, Kawashima T, Kobayashi Y, Sasabayashi D, et al
    • Organizer
      Schizophrenia International Research Society (SIRS) 2023 Congress
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prediction of psychotic disorder in individuals with clinical high-risk state by multimodal machine-learning.2023

    • Author(s)
      Takayanagi Y, Sasabayashi D, Takahashi T, Higuchi Y, Nishiyama S, Tateno T, Mizukami Y, Akasaki Y, Furuichi A, Kobayashi H, Yuasa Y, Takayanagi M, Noguchi K, Tsujii N, Suzuki M
    • Organizer
      Annual Congress of Schizophrenia International Research Society
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] 統合失調症およびARMSにおける海馬亜領域体積変化の縦断的検討.2023

    • Author(s)
      笹林大樹, 石井麗華, 高橋 努, 高柳陽一郎, 古市厚志, 小林春子, 湯浅悠介, 野口 京, 鈴木道雄.
    • Organizer
      第17回日本統合失調症学会
    • Related Report
      2023 Research-status Report
  • [Presentation] 初回エピソード統合失調症におけるその後の再燃の予測: 関連する因子の検討.2023

    • Author(s)
      笹林大樹, 高柳陽一郎, 高橋 努, 樋口悠子, 古市厚志, 小林春子, 野口 京, 鈴木道雄.
    • Organizer
      第42回日本精神科診断学会
    • Related Report
      2023 Research-status Report
  • [Presentation] At-risk mental stateおよび統合失調症 におけるdefault mode network に関連した安静時機能的結合の変化2022

    • Author(s)
      笹林大樹, 高橋努, 高柳陽一郎, 根本清貴, 上野摩耶, 古市厚志, 樋口悠子, 水上祐子, 西山志満子, 小林春子, Tien Viet Pham, 野口 京, 鈴木道雄
    • Organizer
      第16回統合失調症学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 統合失調症を脳のかたちや大きさの特徴から早期に診断することはできるか?2022

    • Author(s)
      笹林大樹
    • Organizer
      第16回統合失調症学会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] ARMS群における大脳皮質厚の変化と 1年後の機能的転帰との関連2022

    • Author(s)
      笹林大樹
    • Organizer
      第16回統合失調症学会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] At-risk mental stateへの臨床的支援 ~Consultation and Support Service in Toyama (CAST)~2022

    • Author(s)
      笹林大樹
    • Organizer
      第200回北陸精神神経学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 統合失調症および妄想性障害におけるdefault mode networkに関連した安静時機能的結合性の増加2022

    • Author(s)
      笹林大樹, 高橋努, 石戸憩, 白井秀昂, 高柳陽一郎, 根本清貴, 上野摩耶, 古市厚志, 小林春子, 野口京, 鈴木道雄
    • Organizer
      第44回日本生物学的精神医学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 精神病性障害における 脳回形成の偏倚に関する研究2022

    • Author(s)
      笹林大樹
    • Organizer
      第44回日本生物学的精神医学会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 初回エピソード統合失調症患者における脳表形態特徴とその後の再燃との関連2022

    • Author(s)
      笹林大樹、高柳陽一郎、高橋努、古市厚志、小林春子、湯浅悠介、野口京、鈴木道雄
    • Organizer
      第25回日本精神保健・予防学会学術集会
    • Related Report
      2022 Research-status Report

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Published: 2022-04-19   Modified: 2024-12-25  

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