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Relations between pancreatic cancer and adipose tissue under cachexia

Research Project

Project/Area Number 22K16043
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionOsaka University

Principal Investigator

Sato Katsuhiko  大阪大学, 大学院医学系研究科, 特任助教(常勤) (40838843)

Project Period (FY) 2022-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2022: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords膵癌 / 悪液質
Outline of Research at the Start

膵癌において脂肪や筋肉の減少を伴う悪液質は予後不良因子である。申請者はマウス由来膵癌細胞株を用いてimmunocompetentな膵癌モデルである膵同所移植モデルを確立した。膵癌同所移植群においてsham群と比べて性腺周囲脂肪重量が減少しており、悪液質状態を呈している。申請者は膵同所移植モデルの性腺周囲脂肪を用いてRNA Sequenceによるtranscriptome解析を行い、膵癌に伴う悪液質下で脂肪からの分泌が増減する候補タンパクを抽出している。そこで、本研究では各候補タンパクが悪液質の病態および膵癌自体に与える影響をin vitro, in vivoおよびヒト血清を用いて検討する。

Outline of Final Research Achievements

Perigonadal fat weight decreased in mice with orthotopic tumors compared to those without tumors. By RNA sequencing and real-time PCR validation, pentraxin 3 (PTX3) was identified as a secreted protein-encoded gene whose expression was significantly higher in the perigonadal fat of mice with orthotopic tumors than in that of mice without orthotopic tumors. Serum PTX3 levels correlated with body weight change and were higher in mice with orthotopic tumors than in those without tumors. In 84 patients diagnosed with metastatic pancreatic cancer, patients with high serum PTX3 levels showed a greater visceral fat loss/month and skeletal muscle mass index (SMI) decrease/month than those with low serum PTX3 levels. High serum PTX3 was an independent risk factor for visceral fat loss, decreased SMI, and poor prognosis.

Academic Significance and Societal Importance of the Research Achievements

悪液質は膵癌を含む多くの癌腫で予後不良因子であることが知られている。膵癌同所移植モデルマウスで担癌状態となることで内臓脂肪が減少することを確認し、内臓脂肪から分泌される悪液質マーカーをRNA sequenceで検討した。同定された血清マーカーPTX3は、遠隔転移を伴う膵癌患者において、炎症と関連する予後因子であり、内臓脂肪、筋肉量減少のマーカーであった。PTX3は膵癌患者の悪液質進行のマーカーとして期待される。

Report

(3 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • Research Products

    (1 results)

All 2022

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Pentraxin 3 is an adipose tissue‐related serum marker for pancreatic cancer cachexia predicting subsequent muscle mass and visceral fat loss2022

    • Author(s)
      Sato Katsuhiko、Hikita Hayato、Shigekawa Minoru、Kato Seiya、Sasaki Yoichi、Shinkai Kazuma、Fukuoka Makoto、Kudo Shinnosuke、Sato Yu、Fukumoto Kenji、Shirai Kumiko、Myojin Yuta、Sakane Sadatsugu、Murai Kazuhiro、Yoshioka Teppei、Nishio Akira、Kodama Takahiro、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancer Science

      Volume: 113 Issue: 12 Pages: 4311-4326

    • DOI

      10.1111/cas.15569

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2022-04-19   Modified: 2025-01-30  

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