糖尿病性腎臓病を中心とした疾患群のメタボロームに関するサブタイプ別探索と応用展開

• Project/Area Number: 22K16212
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53040:Nephrology-related
• Research Institution: Niigata University
• Principal Investigator: 山本 正彦 新潟大学, 日本酒学センター, 特任助教 (50874822)
• Project Period (FY): 2022-04-01 – 2025-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2024: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2022: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 糖尿病性腎臓病 / メタボローム / 生活習慣病 / 糖尿病合併症

Outline of Research at the Start

糖尿病性腎臓病は、糖尿病細小血管合併症を構成する主要な疾患の一つであり、末期腎不全や透析導入に至ることもある。そのため、糖尿病性腎臓病の診断や重症化防止に有用となるバイオマーカーの探索が求められている。本研究では、鶴岡メタボロームコホート研究 (Tsuruoka Metabolomics Cohort Study)の情報を用いて、血漿中のメタボロームに関する網羅的な解析を行い、糖尿病性腎臓病や、そのサブタイプとの関連を明らかにする。

Outline of Annual Research Achievements

糖尿病性腎臓病は糖尿病学、公衆衛生学における重要な課題である。進行した場合には透析導入に至ることもあり、医療面だけでなく、社会・経済面などにおいても、多大な影響を及ぼす。このため、糖尿病性腎臓病の発生・進行防止が喫緊の課題となっている。
本研究では、大規模血漿メタボロミクス・バイオマーカーを用いて、糖尿病性腎臓病の層別化に有用となるメタボロミクス・バイオマーカーを明らかにする。既知の代謝因子やバイオマーカーだけでなく、メタボロミクス・バイオマーカーを加えて検討を行うことにより、メタボロミクス・バイオマーカーの糖尿病性腎臓病予防における有用性を探索する。
これにより、糖尿病性腎臓病の効果的な予防方策を検討する上での、個別化したアプローチが可能となる。現在、国際学会での発表を終え、論文での発表に向けてのまとめ作業を進めつつ、結果に関連する更なる検討を進めているところである。

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

COVID-19感染症の世界的な流行は、変動がみられるものの、いまだに収束しておらず、今後、再び流行が拡大する可能性についての指摘もある。このような状況に伴い、臨床医として診療業務にかける割合が増加し、研究活動に割り当てられるエフォートが低下した。付け加えて、情報収集活動に関連する学術会議等の参加・出席にも影響がでたこともあり、当初想定していた研究活動予定よりも、少々遅れが生じている。

Strategy for Future Research Activity

関連する国際学会での演題発表など、一定の研究実績を挙げている。国際学会での発表実績を学術論文としてまとめ、英文学術誌への採択に向けて、引き続き推進する。
合わせて、これまでに得られた結果に加えて、追加の解析・検討を行うことで、糖尿病性腎臓病を中心とした疾患群のメタボロームに関するサブタイプ別探索を推進する。

Research Products

• [Journal Article] Fast walking and physical activity are independent contributors to improved physical function (2023)
  • Author(s): Shiozaki H, Fujihara K＊, Yamada NH, Yamamoto M, Mitsuma Y, Kitazawa M, Yaguchi Y, Matsubayashi Y, Iwanaga M, Yamada T, Kodama S, Sone H
  • Journal Title: Family Practice Volume: 40 Issue: 2 Pages: 398-401
  • DOI: 10.1093/fampra/cmac087
  • Peer Reviewed / Open Access
• [Journal Article] 472-P: Sex Differences in the Effect of High Serum Uric Acid on the Incidence of Vision-Threatening Retinopathy in Those with Type 2 Diabetes (2022)
  • Author(s): YAMAMOTO MASAHIKO、FUJIHARA KAZUYA、ISHIGURO HAJIME、YAGUCHI YUTA、ISHIZAWA MASAHIRO、YAMADA MAYUKO H.、OSAWA TAEKO、KITAZAWA MASARU、KANEKO MASANORI、MATSUBAYASHI YASUHIRO、IWANAGA MIDORI、YAMADA TAKAHO、KODAMA SATORU、SONE HIROHITO
  • Journal Title: Diabetes Volume: 71 Issue: Supplement_1
  • DOI: 10.2337/db22-472-p
  • Peer Reviewed
• [Journal Article] Impact of metabolic syndrome and metabolic dysfunction-associated fatty liver disease on cardiovascular risk by the presence or absence of type 2 diabetes and according to sex (2022)
  • Author(s): Yasuhiro Matsubayashi, Kazuya Fujihara, Mayuko Yamada-Harada, Yurie Mitsuma, Takaaki Sato, Yuta Yaguchi, Taeko Osawa, Masahiko Yamamoto, Masaru Kitazawa, Takaho Yamada, Satoru Kodama & Hirohito Sone
  • Journal Title: Cardiovascular Diabetology Volume: 21 Issue: 1 Pages: 90-90
  • DOI: 10.1186/s12933-022-01518-4
  • Peer Reviewed / Open Access
• [Journal Article] 325-OR: Associations of Systolic Blood Pressure (SBP) with the Incidence of Heart Failure (HF) According to Glucose Tolerance Status (GTS) (2022)
  • Author(s): FUJIHARA KAZUYA、YAMADA MAYUKO H.、YAMAMOTO MASAHIKO、OE MOMOKO、OSAWA TAEKO、IWANAGA MIDORI、YAMADA TAKAHO、KODAMA SATORU、SONE HIROHITO
  • Journal Title: Diabetes Volume: 71 Issue: Supplement_1
  • DOI: 10.2337/db22-325-or
  • Peer Reviewed
• [Journal Article] 378-P: Network Meta-analysis of Hypoglycemic Treatment Regimens with Potential Risk of Hypoglycemia in Terms of Glycemic Control and Severe Hypoglycemia (2022)
  • Author(s): KODAMA SATORU、SATO TAKAAKI、YAMADA MAYUKO H.、YAMAMOTO MASAHIKO、MATSUBAYASHI YASUHIRO、ISHIGURO HAJIME、IWANAGA MIDORI、FUJIHARA KAZUYA、YAMADA TAKAHO、KATO KIMINORI、WATANABE KENICHI、SONE HIROHITO
  • Journal Title: Diabetes Volume: 71 Issue: Supplement_1
  • DOI: 10.2337/db22-378-p
  • Peer Reviewed
• [Journal Article] 539-P: Evaluation of a Comprehensive Physical Fitness Index to Predict Future Prediabetes and Metabolic Syndrome (MetS) (2022)
  • Author(s): SATO TAKAAKI、FUJIHARA KAZUYA、YAMADA MAYUKO H.、CHO KAORI、YAGUCHI YUTA、YAMAMOTO MASAHIKO、KITAZAWA MASARU、ISHIGURO HAJIME、OSAWA TAEKO、YAMADA TAKAHO、KATO KIMINORI、SONE HIROHITO
  • Journal Title: Diabetes Volume: 71 Issue: Supplement_1
  • DOI: 10.2337/db22-539-p
  • Peer Reviewed
• [Journal Article] 529-P: Impact of Medication Adherence (MA) to Oral Glycemic Agents (OHAs) on Initiation of Dialysis in Patients with Moderately Impaired Renal Function (2022)
  • Author(s): YAGUCHI YUTA、FUJIHARA KAZUYA、YAMADA MAYUKO H.、MATSUBAYASHI YASUHIRO、YAMADA TAKAHO、IWANAGA MIDORI、KITAZAWA MASARU、YAMAMOTO MASAHIKO、KODAMA SATORU、SONE HIROHITO
  • Journal Title: Diabetes Volume: 71 Issue: Supplement_1
  • DOI: 10.2337/db22-529-p
  • Peer Reviewed
• [Journal Article] 1165-P: Combined Severe Diabetic Complications: The New Life-Altering Outcome (2022)
  • Author(s): YAGUCHI YUTA、FUJIHARA KAZUYA、YAMADA MAYUKO H.、MATSUBAYASHI YASUHIRO、YAMADA TAKAHO、IWANAGA MIDORI、KITAZAWA MASARU、YAMAMOTO MASAHIKO、KODAMA SATORU、SONE HIROHITO
  • Journal Title: Diabetes Volume: 71 Issue: Supplement_1
  • DOI: 10.2337/db22-1165-p
  • Peer Reviewed
• [Journal Article] 1091-P: Impact of Metabolic Syndrome and Metabolic Dysfunction-Associated Fatty Liver Disease on Cardiovascular Risk in People with and without Type 2 Diabetes (2022)
  • Author(s): MATSUBAYASHI YASUHIRO、FUJIHARA KAZUYA、YAMADA MAYUKO H.、YAGUCHI YUTA、YAMAMOTO MASAHIKO、ISHIGURO HAJIME、KITAZAWA MASARU、IWANAGA MIDORI、YAMADA TAKAHO、KODAMA SATORU、SONE HIROHITO
  • Journal Title: Diabetes Volume: 71 Issue: Supplement_1
  • DOI: 10.2337/db22-1091-p
  • Peer Reviewed
• [Journal Article] 1439-P: Association between Sleep Duration, Bedtime, and Hyperglycemia or Overweight/Obesity among Japanese Children (2022)
  • Author(s): SHIOZAKI HARUKA、FUJIHARA KAZUYA、YAMADA MAYUKO H.、OSAWA TAEKO、KITAZAWA MASARU、MATSUBAYASHI YASUHIRO、YAGUCHI YUTA、YAMAMOTO MASAHIKO、SATO TAKAAKI、YAMADA TAKAHO、SONE HIROHITO
  • Journal Title: Diabetes Volume: 71 Issue: Supplement_1
  • DOI: 10.2337/db22-1439-p
  • Peer Reviewed
• [Journal Article] 1098-P: Impact of Health Factors on Incident Cardiovascular Disease (CVD) According to Glucose Tolerance Status (2022)
  • Author(s): IIJIMA TAKANOBU、FUJIHARA KAZUYA、YAMADA MAYUKO H.、YAMAMOTO MASAHIKO、OSAWA TAEKO、MATSUBAYASHI YASUHIRO、SATO TAKAAKI、YAGUCHI YUTA、IWANAGA MIDORI、YAMADA TAKAHO、KODAMA SATORU、SONE HIROHITO
  • Journal Title: Diabetes Volume: 71 Issue: Supplement_1
  • DOI: 10.2337/db22-1098-p
  • Peer Reviewed
• [Presentation] Sex Differences in the Effect of High Serum Uric Acid on the Incidence of Vision-Threatening Retinopathy in Those with Type 2 Diabetes (2022)
  • Author(s): Masahiko Yamamoto, Kazuya Fujihara, Hajime Ishiguro, Yuta Yaguchi, Masahiro Ishizawa, Mayuko Yamada-Harada, Taeko Osawa, Masaru Kitazawa, Masanori Kaneko, Yasuhiro Matsubayashi, Midori Iwanaga, Takaho Yamada, Satoru Kodama, Hirohito Sone
  • Organizer: 82nd American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Association between plasma hypoxanthine and diabetic kidney disease (DKD) in a Japanese population (2022)
  • Author(s): Masahiko Yamamoto, Sei Harada, Tomonori Okamura, Kazuya Fujihara, Satoru Kodama, Takaho Yamada, Hirohito Sone, Toru Takebayashi
  • Organizer: 58th European Association for the Study of Diabetes (EASD) Annual Meeting
  • Int'l Joint Research
• [Presentation] Associations of Systolic Blood Pressure (SBP) with the Incidence of Heart Failure (HF) According to Glucose Tolerance Status (GTS) (2022)
  • Author(s): KAZUYA FUJIHARA, MAYUKO H. YAMADA, MASAHIKO YAMAMOTO, MOMOKO OE, TAEKO OSAWA, MIDORI IWANAGA, TAKAHO YAMADA, SATORU KODAMA, HIROHITO SONE
  • Organizer: 82nd American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Network Meta-analysis of Hypoglycemic Treatment Regimens with Potential Risk of Hypoglycemia in Terms of Glycemic Control and Severe Hypoglycemia (2022)
  • Author(s): SATORU KODAMA, TAKAAKI SATO, MAYUKO H. YAMADA, MASAHIKO YAMAMOTO, YASUHIRO MATSUBAYASHI, HAJIME ISHIGURO, MIDORI IWANAGA,KAZUYA FUJIHARA,TAKAHO YAMADA, KIMINORI KATO, ;KENICHI WATANABE, HIROHITO SONE
  • Organizer: 82nd American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Evaluation of a Comprehensive Physical Fitness Index to Predict Future Prediabetes and Metabolic Syndrome (MetS) (2022)
  • Author(s): TAKAAKI SATO, KAZUYA FUJIHARA, MAYUKO H. YAMADA, KAORI CHO, YUTA YAGUCHI, MASAHIKO YAMAMOTO, MASARU KITAZAWA, HAJIME ISHIGURO, TAEKO OSAWA, TAKAHO YAMADA, KIMINORI KATO, HIROHITO SONE
  • Organizer: 82nd American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Impact of Medication Adherence (MA) to Oral Glycemic Agents (OHAs) on Initiation of Dialysis in Patients with Moderately Impaired Renal Function (2022)
  • Author(s): YUTA YAGUCHI, KAZUYA FUJIHARA, MAYUKO H. YAMADA, YASUHIRO MATSUBAYASHI, TAKAHO YAMADA, MIDORI IWANAGA, MASARU KITAZAWA, MASAHIKO YAMAMOTO, SATORU KODAMA, HIROHITO SONE
  • Organizer: 82nd American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Combined Severe Diabetic Complications: The New Life-Altering Outcome (2022)
  • Author(s): YUTA YAGUCHI, KAZUYA FUJIHARA, MAYUKO H. YAMADA, YASUHIRO MATSUBAYASHI, TAKAHO YAMADA, MIDORI IWANAGA, MASARU KITAZAWA, MASAHIKO YAMAMOTO, SATORU KODAMA, HIROHITO SONE
  • Organizer: 82nd American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Impact of Metabolic Syndrome and Metabolic Dysfunction-Associated Fatty Liver Disease on Cardiovascular Risk in People with and without Type 2 Diabetes (2022)
  • Author(s): YASUHIRO MATSUBAYASHI, KAZUYA FUJIHARA, MAYUKO H. YAMADA, YUTA YAGUCHI, MASAHIKO YAMAMOTO, HAJIME ISHIGURO, MASARU KITAZAWA, MIDORI IWANAGA, TAKAHO YAMADA, SATORU KODAMA, HIROHITO SONE
  • Organizer: 82nd American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Association between Sleep Duration, Bedtime, and Hyperglycemia or Overweight/Obesity among Japanese Children (2022)
  • Author(s): HARUKA SHIOZAKI, KAZUYA FUJIHARA, MAYUKO H. YAMADA, TAEKO OSAWA, MASARU KITAZAWA, YASUHIRO MATSUBAYASHI, YUTA YAGUCHI, MASAHIKO YAMAMOTO, TAKAAKI SATO, TAKAHO YAMADA, HIROHITO SONE
  • Organizer: 82nd American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research
• [Presentation] Impact of Health Factors on Incident Cardiovascular Disease (CVD) According to Glucose Tolerance Status (2022)
  • Author(s): TAKANOBU IIJIMA, KAZUYA FUJIHARA, MAYUKO H. YAMADA, MASAHIKO YAMAMOTO, TAEKO OSAWA, YASUHIRO MATSUBAYASHI, TAKAAKI SATO, YUTA YAGUCHI, MIDORI IWANAGA, TAKAHO YAMADA, SATORU KODAMA, HIROHITO SONE
  • Organizer: 82nd American Diabetes Association Scientific Sessions (ADA)
  • Int'l Joint Research