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AI-Driven Resection Planning System to Optimize Postoperative Outcomes in Focal Epilepsy Surgery

Research Project

Project/Area Number 22K16664
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56010:Neurosurgery-related
Research InstitutionYokohama City University

Principal Investigator

SONODA Masaki  横浜市立大学, 医学部, 助教 (90881227)

Project Period (FY) 2022-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2023: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2022: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords頭蓋内脳波記録 / 人工知能 / 言語機能 / 記憶機能 / 認知機能 / 脳内ネットワーク / 移動エントロピー / てんかん外科 / 認知記憶課題 / 聴覚性呼称課題 / 視覚性呼称課題 / 皮質電気刺激 / ネットワーク解析 / 予測モデル / 言語ネットワーク / 認知機能解析 / 周術期認知機能 / 手術支援
Outline of Research at the Start

本研究はてんかん診療現場における, 術後成績(発作制御率と認知機能変化)の改善を目的とし,てんかん焦点切除術を行う際に, 認知機能課題中の脳表脳波記録解析を加えて、切除範囲を決める診断過程に人工知能(AI)を用いた術後成績を最適化する切除範囲を提案する「AI診断システム」の開発を目指す.臨床現場で運用可能な同システムは, 術後成績を最適化する3次元切除範囲を手軽でわかりやすく提供する. 日米てんかんセンターの約200人分, 約20,000箇所の脳表脳波記録を教師データとしてAIツールを構築する。

Outline of Final Research Achievements

In our research, we’ve developed a new device that records brain activity to predict cognitive decline after epilepsy surgery. By recording EEG data from Japanese-speaking patients, we aim to create an artificial intelligence model that predicts which brain areas to remove for the most effective surgical outcomes. Our findings have already been presented at several conferences, and we plan to refine the AI model further by gathering additional data.

Academic Significance and Societal Importance of the Research Achievements

この研究の学術的な意義は、脳神経外科手術における意思決定プロセスを革新する可能性にある。人工知能モデルを使用することで、手術前の詳細な脳波分析を通じて、患者の認知機能を維持しつつ、最も効果的な手術範囲を予測することができる。さらに、この研究は、脳の言語認知機能と記憶機能の理解を深めることにも寄与し、てんかん治療だけでなく、他の脳疾患の治療法の開発にも応用可能である。

Report

(3 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • Research Products

    (7 results)

All 2023

All Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Sevoflurane-induced high-frequency oscillations, effective connectivity and intraoperative classification of epileptic brain areas2023

    • Author(s)
      Firestone Ethan、Sonoda Masaki、Kuroda Naoto、Sakakura Kazuki、Jeong Jeong-Won、Lee Min-Hee、Wada Keiko、Takayama Yutaro、Iijima Keiya、Iwasaki Masaki、Miyazaki Tomoyuki、Asano Eishi
    • Journal Title

      Clinical Neurophysiology

      Volume: 150 Pages: 17-30

    • DOI

      10.1016/j.clinph.2023.03.004

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intra? and inter?hemispheric network dynamics supporting object recognition and speech production2023

    • Author(s)
      Kitazawa Yu、Sonoda Masaki、Sakakura Kazuki、Mitsuhashi Takumi、Firestone Ethan、Ueda Riyo、Kambara Toshimune、Iwaki Hirotaka、Luat Aimee F.、Marupudi Neena I.、Sood Sandeep、Asano Eishi
    • Journal Title

      NeuroImage

      Volume: 270 Pages: 119954-119954

    • DOI

      10.1016/j.neuroimage.2023.119954

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dynamic cortical and tractography atlases of proactive and reactive alpha and high-gamma activities2023

    • Author(s)
      Ono Hiroya、Sonoda Masaki、Sakakura Kazuki、Kitazawa Yu、Mitsuhashi Takumi、Firestone Ethan、Jeong Jeong-Won、Luat Aimee F、Marupudi Neena I、Sood Sandeep、Asano Eishi
    • Journal Title

      Brain Communications

      Volume: 5 Issue: 2

    • DOI

      10.1093/braincomms/fcad111

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Incomplete hippocampal inversion in patients with mutations in genes involved in sonic hedgehog signaling2023

    • Author(s)
      Higashijima Takefumi、Shirozu Hiroshi、Saitsu Hirotomo、Sonoda Masaki、Fujita Atsushi、Masuda Hiroshi、Yamamoto Tetsuya、Matsumoto Naomichi、Kameyama Shigeki
    • Journal Title

      Heliyon

      Volume: 9 Issue: 4 Pages: e14712-e14712

    • DOI

      10.1016/j.heliyon.2023.e14712

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] マルチモダリティデータ解析による言語機能の可視化と臨床応用」-皮質脳波解析とトラクトグラフィー解析-2023

    • Author(s)
      園田真樹
    • Journal Title

      Medical Science Digest

      Volume: 49

    • Related Report
      2023 Annual Research Report
  • [Presentation] てんかん病態と生理的脳内ネットワークのダイナミクス解析- 視床下部過誤腫に伴う認知機能障害を中心に-2023

    • Author(s)
      園田真樹
    • Organizer
      第56回日本てんかん学会学術集会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Sevoflurane-based enhancement of phase-amplitude coupling and localization of the epileptogenic zone.2023

    • Author(s)
      Sonoda M, Wada K, Firestone E, Sakakura K, Kuroda N, Takayama Y, Iijima K, Iwasaki M, Mihara T, Goto T, Yamamoto T, Asano E, Miyazaki T
    • Organizer
      The American Epilepsy Society 77th Annual Meeting (AES2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research

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Published: 2022-04-19   Modified: 2025-01-30  

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