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Effect of stannous fluoride containing toothpaste on root caries prevention using nondestructive testing and solid-state NMR

Research Project

Project/Area Number 22K17047
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionNihon University

Principal Investigator

SHIBASAKI Sho  日本大学, 歯学部, 助教 (70822633)

Project Period (FY) 2022-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2023: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsフッ化スズ / 根面齲蝕 / 齲蝕予防 / 超音波透過法 / 固体核磁気共鳴法
Outline of Research at the Start

超高齢化社会が進行する本邦において,喫緊の問題として根面齲蝕への対応が挙げられる。フッ化スズは,抗齲蝕や象牙質知覚過敏抑制などの作用がある一方で,加水分解や歯面着色などの理由から,歯磨剤への添加は困難とされてきた。近年,技術革新により象牙質知覚過敏症を対象としてフッ化スズ含有歯磨剤の応用が欧米を中心に行われている。そこで本研究ではフッ化スズ含有歯磨剤の根面齲蝕予防への応用を目的として,根面齲蝕モデルにフッ化スズ濃度の異なる歯磨剤を応用し,機械的性質変化を超音波透過法を用いて,化学的組成変化を固体核磁気共鳴法を用いて評価することで,根面齲蝕予防に至適なフッ化スズ濃度を検討する。

Outline of Final Research Achievements

The used toothpastes were the stannous fluoride containing tooth paste (ST) and the sodium fluoride containing tooth paste (SO). Distilled water was used instead of toothpastes as the control group. In the results of ultrasonic measurements, all the brushing groups showed no significant differences in V among the brushing period. In the results of KHN, although all the groups showed decreased KHN with increased brushing periods, the KHN of ST were significantly higher than those of the other groups. From the results of this study, the ability of prevention root caries in stannous fluoride containing toothpaste might be equal or greater when compared to that of sodium fluoride containing toothpaste.

Academic Significance and Societal Importance of the Research Achievements

超高齢社会の進行に伴った高齢者の残存歯数の増加によって,根面齲蝕が増加傾向にある。根面齲蝕はその性質上,修復操作が困難となる症例も多い。また根面齲蝕を有する高齢者は通院を伴う歯科医院での治療が困難となる場合も多く,セルフケアを主体とした根面齲蝕予防が重要と考えられる。特に,フッ化スズが有する抗齲蝕性,抗炎症作用,象牙質知覚過敏抑制,抗菌性,口臭および酸蝕抑制効果は特筆すべきものであり,フッ化スズ含有歯磨剤を根面齲蝕予防に応用できれば歯科領域への貢献は大であると考えられる。

Report

(3 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • Research Products

    (3 results)

All 2024 2023

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Effect of different pretreatment agents on intact or ground enamel bond performance of different types of adhesive systems2024

    • Author(s)
      Muto Rei、Takamizawa Toshiki、Shoji Mone、Hirokane Eizo、Shibasaki Sho、Barkmeier Wayne W.、Latta Mark A.、Miyazaki Masashi
    • Journal Title

      International Journal of Adhesion and Adhesives

      Volume: 132 Pages: 103698-103698

    • DOI

      10.1016/j.ijadhadh.2024.103698

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Comparison of dentin bond durability in different adhesive systems containing glycerol-phosphate dimethacrylate (GPDM) functional monomers under long-term water storage2023

    • Author(s)
      Koike K, Takamizawa T, Aoki R, Shibasaski S, Ishii R, Sai Keiichi, Kamimoto A, Miyazaki M
    • Journal Title

      Int J Adhes Adhes

      Volume: 124 Pages: 103366-103366

    • DOI

      10.1016/j.ijadhadh.2023.103366

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] オフィスホワイトニング材の濃度および塗布時間が ホワイトニング効果に及ぼす影響2023

    • Author(s)
      柴崎 翔,青木良太,庄司元音,髙見澤俊樹,宮崎真至
    • Organizer
      日本歯科審美学会第34回学術大会
    • Related Report
      2023 Annual Research Report

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Published: 2022-04-19   Modified: 2025-01-30  

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