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Investigation of the Effects of Oral Health on Systemic Health and Development of Economic Evaluation Indicators: A Quasi-Randomized Controlled Study

Research Project

Project/Area Number 22K17285
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57080:Social dentistry-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Matsuyama Yusuke  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (80830124)

Project Period (FY) 2022-04-01 – 2025-03-31
Project Status Discontinued (Fiscal Year 2024)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2024: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2023: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2022: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords歯科疫学 / 歯科公衆衛生学 / 因果推論 / 自然実験 / 歯科公衆衛生 / 歯科学 / 疫学 / 公衆衛生学 / 公衆衛生 / 口腔と全身
Outline of Research at the Start

口腔疾患は世界の2人に1人以上にみられる公衆衛生上の重要な課題である。多くの人が罹患するため、歯科医療費の社会的負担も大きい。しかし、現状では口腔と全身の健康の因果関係が明らかでないため、口腔疾患の影響の大きさを適切に推定できず、口腔の重要性が過小評価されている可能性がある。本研究は地域環境の違いを活用した自然実験により、口腔と全身の健康の因果関係を明らかにする。さらに、多様な口腔関連QoLを効用値に換算するアルゴリズムを開発する。これにより、口腔保健推進により得られる社会のWell-being増進量を明らかにし、口腔保健政策における医療資源配分のための知見を得る。

Outline of Final Research Achievements

Oral diseases are an important public health issue that affects many people. However, the causal relationship between oral conditions and systemic health is currently understudied, and the importance of oral health is underestimated. This study conducted research to investigate the causal relationship between oral conditions and systemic health, as well as research to quantify the disease burden of oral diseases. The results revealed that the loss of natural teeth increases the risk of cardiovascular disease and decline of physical and cognitive function. It highlighted the significant burden of oral diseases on society.

Academic Significance and Societal Importance of the Research Achievements

本研究から、口腔疾患が全身の健康を悪化させるという因果関係を支持する結果を得た。その影響の大きさは集団レベルで大きいことから、口腔疾患への対策を進める公衆衛生施策により集団の健康度が改善される可能性が示唆された。口腔疾患は大部分が予防可能と考えられていることからも、政策や臨床レベルでの対策が重要である。一方で、詳細なメカニズムの解明や、口腔疾患に罹患している期間の影響を明らかにすることは今後の研究の課題である。

Report

(3 results)
  • 2024 Final Research Report ( PDF )
  • 2023 Annual Research Report
  • 2022 Research-status Report
  • Research Products

    (8 results)

All 2024 2023 2022 Other

All Int'l Joint Research (3 results) Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (1 results)

  • [Int'l Joint Research] Boston University(米国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Radboud University Medical Center(オランダ)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] University of Wuppertal(ドイツ)

    • Related Report
      2022 Research-status Report
  • [Journal Article] Heterogeneous Association of Tooth Loss with Functional Limitations2024

    • Author(s)
      Matsuyama Y.、Aida J.、Kondo K.、Shiba K.
    • Journal Title

      Journal of Dental Research

      Volume: 103 Issue: 4 Pages: 369-377

    • DOI

      10.1177/00220345241226957

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Does Tobacco Smoking Increase Social Isolation? A Mendelian Randomization Study2023

    • Author(s)
      Matsuyama Yusuke、Tabuchi Takahiro
    • Journal Title

      American Journal of Epidemiology

      Volume: - Issue: 4 Pages: 626-635

    • DOI

      10.1093/aje/kwad229

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tap water natural fluoride and parent‐reported experience of child dental caries in Japan: Evidence from a nationwide birth cohort survey2023

    • Author(s)
      Matsuyama Yusuke、Fujiwara Takeo、Aida Jun
    • Journal Title

      Community Dentistry and Oral Epidemiology

      Volume: - Issue: 6 Pages: 1141-1149

    • DOI

      10.1111/cdoe.12847

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Causal Effect of Tooth Loss on Cardiovascular Diseases2022

    • Author(s)
      Matsuyama Y.、Jurges H.、Listl S.
    • Journal Title

      Journal of Dental Research

      Volume: 102 Issue: 1 Pages: 37-44

    • DOI

      10.1177/00220345221120164

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 日本における水道水天然フッ化物濃度と子どものう蝕の関連:21世紀出生児縦断調査の分析2022

    • Author(s)
      松山祐輔、藤原武男、相田潤
    • Organizer
      第81回日本公衆衛生学会総会
    • Related Report
      2022 Research-status Report

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Published: 2022-04-19   Modified: 2026-01-16  

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