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Neural mechanisms of the effects of very light intensity exercise on mood and cognitive function: an fMRI study

Research Project

Project/Area Number 22K17808
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionRyutsu Keizai University

Principal Investigator

SUWABE Kazuya  流通経済大学, スポーツ健康科学部, 准教授 (80816413)

Project Period (FY) 2022-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2023: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2022: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords超低強度運動 / 気分 / 認知機能 / MRI
Outline of Research at the Start

運動が気分や認知機能などのメンタルヘルスに有益であることが明らかになりつつあるが、どんな運動が効果的か、またその作用機序は未解明である。申請者らは、軽い強度の有酸素運動が海馬や前頭前野の認知機能を高める効果を明らかにしてきた。想定されるメカニズムの一つとして、軽運動時には単に運動関連領域が賦活するだけでなく、海馬や前頭前野など認知機能に関連する脳領域の活動が調節されることで機能が高まることが考えられるが、仮説の域を出ない。本研究は、機能的MRI(fMRI)を用いて運動時及び運動前後の脳活動パターンを評価し、気分や認知機能を高める超低強度運動の効果の脳内メカニズムを明らかにする。

Outline of Final Research Achievements

The beneficial effects of physical exercise, particularly very light-intensity aerobic exercise, on mental health, including mood and cognitive function, are gradually becoming evident. Although the neural mechanisms underlying this effects have not yet been elucidated, exercise may modulate activity patterns not only in exercise-related areas but also in cognitively related areas such as the hippocampus and prefrontal cortex. The present study tried to test this hypothesis based on fMRI measurements during and before/after exercise using an MRI-compatible ergometer. Although it was difficult to analyze during exercise due to the effects of head motion, the analysis of pre- and post-exercise, excluding those with greater head motion, showed that the functional connectivity between the hippocampus and other regions, including cognitive and motor-related regions, tended to be enhanced after exercise compared with before exercise.

Academic Significance and Societal Importance of the Research Achievements

超低強度運動が気分や認知機能を高める脳内メカニズムに関して、運動時の脳活動計測では信頼できるデータの取得、分析には至らなかったが、運動前後のデータを用いた分析から、仮説を一部支持する結果が得られた。これらの成果は、認知機能に対する運動効果の脳内メカニズム解明に向けた研究を加速させると同時に、運動時の脳活動計測に関する研究を進める上で貴重な知見となり得る。

Report

(3 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • Research Products

    (15 results)

All 2024 2023 2022 Other

All Journal Article (9 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 8 results,  Open Access: 7 results) Presentation (5 results) (of which Int'l Joint Research: 2 results) Remarks (1 results)

  • [Journal Article] Improvement of mnemonic discrimination with acute light exercise is mediated by pupil-linked arousal in healthy older adults2024

    • Author(s)
      Suwabe Kazuya、Kuwamizu Ryuta、Hyodo Kazuki、Yoshikawa Toru、Otsuki Takeshi、Zempo-Miyaki Asako、Yassa Michael A.、Soya Hideaki
    • Journal Title

      Neurobiology of Aging

      Volume: 133 Pages: 107-114

    • DOI

      10.1016/j.neurobiolaging.2023.09.006

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ラジオ体操第一の音楽伴奏が気分や体つくり運動のねらいに対する自己評価に及ぼす影響:大学生を対象にした検討2024

    • Author(s)
      諏訪部和也
    • Journal Title

      流通経済大学スポーツ健康科学部紀要

      Volume: 17 Pages: 1-8

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Groove Rhythm Enhances Exercise Impact on Prefrontal Cortex Function in Groove Enjoyers2023

    • Author(s)
      Fukuie Takemune、Suwabe Kazuya、Kawase Satoshi、Shimizu Takeshi、Ochi Genta、Kuwamizu Ryuta、Sakairi Yosuke、Soya Hideaki
    • Journal Title

      Neuroscience

      Volume: 531 Pages: 117-129

    • DOI

      10.1016/j.neuroscience.2023.08.039

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mild exercise improves executive function with increasing neural efficiency in the prefrontal cortex of older adults2023

    • Author(s)
      Kyeongho Byun, Kazuki Hyodo, Kazuya Suwabe, Takemune Fukuie, Min-seong Ha, Chorphaka Damronthai, Ryuta Kuwamizu, Hikaru Koi-zumi, Michael A. Yassa, Hideaki Soya
    • Journal Title

      GeroScience

      Volume: - Issue: 1 Pages: 309-325

    • DOI

      10.1007/s11357-023-00816-3

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 低強度運動による高齢者の記憶向上効果を予測する瞳孔動態2023

    • Author(s)
      諏訪部和也
    • Journal Title

      体育の科学

      Volume: 73 Pages: 675-680

    • Related Report
      2023 Annual Research Report
  • [Journal Article] A possible contribution of the locus coeruleus to arousal enhancement with mild exercise: evidence from pupillometry and neuromelanin imaging2023

    • Author(s)
      Yamazaki Yudai、Suwabe Kazuya、Nagano-Saito Atsuko、Saotome Kousaku、Kuwamizu Ryuta、Hiraga Taichi、Torma Ferenc、Suzuki Kenji、Sankai Yoshiyuki、Yassa Michael A、Soya Hideaki
    • Journal Title

      Cerebral Cortex Communications

      Volume: 4 Issue: 2 Pages: 1-8

    • DOI

      10.1093/texcom/tgad010

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pupil-linked arousal with very light exercise: pattern of pupil dilation during graded exercise2022

    • Author(s)
      Kuwamizu R, Yamazaki Y, Aoike N, Ochi G, Suwabe K, Soya H
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 72 Issue: 1 Pages: 1-9

    • DOI

      10.1186/s12576-022-00849-x

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cognitive fatigue due to exercise under normobaric hypoxia is related to hypoxemia during exercise2022

    • Author(s)
      Ochi Genta、Kuwamizu Ryuta、Suwabe Kazuya、Fukuie Takemune、Hyodo Kazuki、Soya Hideaki
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 1-10

    • DOI

      10.1038/s41598-022-14146-5

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Groove rhythm stimulates prefrontal cortex function in groove enjoyers2022

    • Author(s)
      Fukuie Takemune、Suwabe Kazuya、Kawase Satoshi、Shimizu Takeshi、Ochi Genta、Kuwamizu Ryuta、Sakairi Yosuke、Soya Hideaki
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 1-14

    • DOI

      10.1038/s41598-022-11324-3

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Development of bedtime stretching program enhancing mood and cognitive function2023

    • Author(s)
      Suwabe Kazuya、Hyodo Kazuki、 Otsuki Takeshi
    • Organizer
      European College of Sport Science
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High-groove music boosts self-selected jogging speed and positive mood in university students2023

    • Author(s)
      Hirota Yuma、Suwabe Kazuya、Otsuki Takeshi、Kawase Satoshi
    • Organizer
      European College of Sport Science
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マーカーレス動作分析システムを用いた体幹回旋動作の評価法開発2023

    • Author(s)
      諏訪部和也、大津卓也
    • Organizer
      日本体操学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Human brain activity during very light intensity exercise using MRI- compatible ergometer: the second preliminary analysis2023

    • Author(s)
      Kazuya Suwabe, Atsuko Nagano-Saito, Yudai Yamazaki, Ryuta Kuwamizu, Akira Matsushita, Morimasa Kato, Kenji Suzuki, Hideaki Soya
    • Organizer
      ARIHHP Human High Performance Forum 2023
    • Related Report
      2022 Research-status Report
  • [Presentation] 軽度低酸素による海馬機能変化はSpO2低下に依存する2022

    • Author(s)
      山﨑雄大、李東旻、諏訪部和也、越智元太、青池直樹、桑水隆多、征矢英昭
    • Organizer
      第77回日本体力医学会大会
    • Related Report
      2022 Research-status Report
  • [Remarks] スポーツ健康科学部 諏訪部准教授らの新研究結果が米科学誌に掲載!

    • URL

      https://www.rku.ac.jp/news/39743/

    • Related Report
      2023 Annual Research Report

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Published: 2022-04-19   Modified: 2025-01-30  

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